Hyperhomocysteinemia recurrence in levodopa-treated Parkinson's disease patients.

Abstract:

BACKGROUND:Patients with Parkinson's disease (PD) and chronically treated with L-DOPA exhibit, in a percentage of 10-30%, supra-physiological levels of plasma total homocysteinemia (tHcy). In this study, we have investigated, in a group of hyper-homocysteinemic PD patients, the time of hyper-tHcy recurrence after discontinuation of 1-month folate supplementation given to normalize plasma tHcy levels. METHODS:Plasma tHcy, cobalamin and folate were assayed before and after 1-month folate supplementation (5 mg/day), and after 2 and 4 months after folate discontinuation in 29 PD patients (16M/13F, mean age 69.4 +/- 6.9 years) stabilized on a mean L-DOPA dose of 509.4 +/- 312.1 mg/day. RESULTS:After folate supplementation, plasma tHcy levels fell within the normal range in all patients. At the 2-month control after folate discontinuation, plasma tHcy remained within physiological values in 25 out of 29 patients. Conversely, 4 months after folate discontinuation, all patients exhibited hyper-tHcy. CONCLUSIONS:One-month intake of 5 mg/day folate normalizes plasma tHcy levels in all hyper-homocysteinemic PD patients. Following folate discontinuation, hyper-tHcy recurs in all patients within 4 months. Knowledge of this time interval is useful to optimize pulses of folate therapy in hyper-homocysteinemic patients with PD.

journal_name

Eur J Neurol

authors

Belcastro V,Pierguidi L,Castrioto A,Menichetti C,Gorgone G,Ientile R,Pisani F,Rossi A,Calabresi P,Tambasco N

doi

10.1111/j.1468-1331.2009.02894.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

661-5

issue

5

eissn

1351-5101

issn

1468-1331

pii

ENE2894

journal_volume

17

pub_type

杂志文章
  • Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits. Data from the Italian CIDP Database.

    abstract:BACKGROUND AND PURPOSE:The role of lifestyle and dietary habits and antecedent events has not been clearly identified in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). METHODS:Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14044

    authors: Doneddu PE,Bianchi E,Cocito D,Manganelli F,Fazio R,Filosto M,Mazzeo A,Cosentino G,Cortese A,Jann S,Clerici AM,Antonini G,Siciliano G,Luigetti M,Marfia GA,Briani C,Lauria G,Rosso T,Cavaletti G,Carpo M,Benedetti L,

    更新日期:2020-01-01 00:00:00

  • Progressive visual loss due to a muslinoma--report of a case and review of the literature.

    abstract::Intracranial internal carotid artery (ICA) aneurysms are frequently treated either by microsurgical clipping of the aneurysm neck, by endovascular coiling of the aneurysm sac or by balloon occlusion of the parent vessel. For some broad-based aneurysms that may not be suitable for any of these options, microsurgical wr...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2003.00546.x

    authors: Berger C,Hartmann M,Wildemann B

    更新日期:2003-03-01 00:00:00

  • Variables linked to psychotic symptoms in Alzheimer's disease.

    abstract::This study is aimed at assessing the prevalence and features of psychotic symptoms in a sample of 180 patients with Alzheimer's disease (AD). Sixty-four patients (35.5% of the sample) showed one or more psychotic symptoms. The presence of these symptoms correlated with the severity of the patients' cognitive impairmen...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1998.560553.x

    authors: Sala SD,Francescani A,Muggia S,Spinnler H

    更新日期:1998-11-01 00:00:00

  • Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry.

    abstract::The Australian Pregnancy Registry, affiliated European Register of Antiepileptic drugs in Pregnancy (EURAP), recruits informed consenting women with epilepsy on treatment with antiepileptic drugs (AEDs), those untreated, and women on AEDs for other indications. Enrolment is considered prospective if it has occurred be...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01359.x

    authors: Vajda FJ,Hitchcock A,Graham J,Solinas C,O'Brien TJ,Lander CM,Eadie MJ

    更新日期:2006-06-01 00:00:00

  • Association of the glucocerebrosidase N370S allele with Parkinson's disease in two separate Chinese Han populations of mainland China.

    abstract:BACKGROUND AND PURPOSE:Mutations in the glucocerebrosidase (GBA) gene have been implicated in the development of Parkinson's disease (PD). However, recent screenings for GBA mutations in PD subjects from different ethnic populations have yielded contradictory results. METHODS:We performed a case-control study to look ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03097.x

    authors: Hu FY,Xi J,Guo J,Yu LH,Liu L,He XH,Liu ZL,Zou XY,Xu YM

    更新日期:2010-12-01 00:00:00

  • EFNS guideline on the drug treatment of migraine - report of an EFNS task force.

    abstract::Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1468-1331.2006.01411.x

    authors: Members of the task force:.,Evers S,Afra J,Frese A,Goadsby PJ,Linde M,May A,Sándor PS

    更新日期:2006-06-01 00:00:00

  • The epidemiology of multiple sclerosis in Europe.

    abstract::Multiple sclerosis (MS) is a chronic and potentially highly disabling disorder with considerable social impact and economic consequences. It is the major cause of non-traumatic disability in young adults. The social costs associated with MS are high because of its long duration, the early loss of productivity, the nee...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2006.01342.x

    authors: Pugliatti M,Rosati G,Carton H,Riise T,Drulovic J,Vécsei L,Milanov I

    更新日期:2006-07-01 00:00:00

  • Clinical and molecular analysis of 11 Sicilian SCA2 families: influence of gender on age at onset.

    abstract::Autosomal dominant cerebellar ataxias (ADCAs) are a complex group of slowly progressive neurodegenerative disorders characterized by gait and stance ataxia, dysarthria and other symptoms of nervous system involvement. ADCA type I is the commonest form and is genetically heterogeneous; several loci have been identified...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1999.630301.x

    authors: Giuffrida S,Lanza S,Restivo DA,Saponara R,Valvo SC,Le Pira F,Trovato Salinaro A,Spinella F,Nicoletti A,Condorelli DF

    更新日期:1999-05-01 00:00:00

  • Overactive bladder in Parkinson's disease: alteration of brainstem raphe detected by transcranial sonography.

    abstract::Urinary dysfunction is very common in idiopathic Parkinson's disease (PD) and manifests primarily with symptoms of overactive bladder (OAB). Affection of central serotonergic systems has been suggested to play a role in OAB. The objective of this study was to evaluate whether in PD patients with OAB symptoms a specifi...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01463.x

    authors: Walter U,Dressler D,Wolters A,Wittstock M,Benecke R

    更新日期:2006-12-01 00:00:00

  • Weekly IM interferon beta-1a in multiple sclerosis patients over 50 years of age.

    abstract:BACKGROUND:Efficacy and safety data have not previously been compiled for intramuscular interferon beta-1a (IM IFNβ-1a) in patients with multiple sclerosis (MS) ≥ 50 years of age. We investigated the efficacy and safety of IM IFNβ-1a in patients segregated by 50 and 40 years of age in separate meta-analyses. METHODS:T...

    journal_title:European journal of neurology

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1468-1331.2011.03460.x

    authors: Lampl C,You X,Limmroth V

    更新日期:2012-01-01 00:00:00

  • Early changes of nerve integrity in preclinical carriers of hereditary transthyretin Ala117Ser amyloidosis with polyneuropathy.

    abstract:BACKGROUND AND PURPOSE:Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers. METHODS:This st...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14698

    authors: Chiang MC,Yeh TY,Sung JY,Hsueh HW,Kao YH,Hsueh SJ,Chang KC,Feng FP,Lin YH,Chao CC,Hsieh ST

    更新日期:2020-12-28 00:00:00

  • Adult-onset very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD).

    abstract:BACKGROUND AND PURPOSE:Very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is a hereditary disorder of mitochondrial long-chain fatty acid oxidation that has variable presentations, including exercise intolerance, cardiomyopathy and liver disease. The aim of this study was to describe the clinical and genetic ma...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14402

    authors: Fatehi F,Okhovat AA,Nilipour Y,Mroczek M,Straub V,Töpf A,Palibrk A,Peric S,Rakocevic Stojanovic V,Najmabadi H,Nafissi S

    更新日期:2020-11-01 00:00:00

  • Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3β) on the risk of Parkinson's disease.

    abstract:BACKGROUND:Oxidative stress is a central factor in the pathogenesis of Parkinson's disease (PD). Heme oxygenase-1 (HO-1) is an antioxidant protein expressed in response to oxidative challenge, and its expression levels are inversely correlated with glycogen synthase kinase-3beta (GSK3beta) activity. Underexpression of ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02908.x

    authors: Infante J,García-Gorostiaga I,Sánchez-Juan P,Sierra M,Martín-Gurpegui JL,Terrazas J,Mateo I,Rodríguez-Rodríguez E,Berciano J,Combarros O

    更新日期:2010-05-01 00:00:00

  • Rebound intracranial hypertension after treatment of spontaneous intracranial hypotension.

    abstract::Spontaneous intracranial hypotension (SIH) is characterized by orthostatic headache and the cause is usually cerebrospinal fluid leaks in spine level. Most patients with SIH have a benign course. Epidural blood patch (EBP) is the treatment of choice when initial conservative managements are ineffective. We reported a ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01369.x

    authors: Tsui H,Wu S,Kuo H,Chen C

    更新日期:2006-07-01 00:00:00

  • The effects of interferon-beta on interleukin-10 in multiple sclerosis patients.

    abstract::The incidence of the neuropathological lesions and the severity of the clinical symptoms in multiple sclerosis (MS) are correlated with the amount of the transferred autoreactive T cells. The balance between the T helper 1 (Th1) and T helper 2 (Th2) cytokine phenotypes may affect the activity of the disease in MS pati...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1468-1331.2004.00986.x

    authors: Ersoy E,Kuş CN,Sener U,Coker I,Zorlu Y

    更新日期:2005-03-01 00:00:00

  • Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis.

    abstract:BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS) is classically assumed to be a neurodegenerative disorder. Inflammation has been observed in CNS tissue in ALS patients. We investigated the expression and prognostic relevance of proinflammatory chemokines in ALS. METHODS:We analyzed nine chemokines, eotaxin,...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02560.x

    authors: Kuhle J,Lindberg RL,Regeniter A,Mehling M,Steck AJ,Kappos L,Czaplinski A

    更新日期:2009-06-01 00:00:00

  • Stroke in first-degree relatives of patients with cervical artery dissection.

    abstract:BACKGROUND AND PURPOSE:Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were com...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12437

    authors: Kloss M,Grond-Ginsbach C,Pezzini A,Metso TM,Metso AJ,Debette S,Leys D,Dallongeville J,Caso V,Thijs V,Bersano A,Touzé E,Bonati LH,Tatlisumak T,Arnold ML,Lyrer PA,Engelter ST,Cervical Artery Dissection and Ischemic Stroke

    更新日期:2014-08-01 00:00:00

  • Post-stroke pathological crying: frequency and correlation to depression.

    abstract::While pathological crying has classically been described as a disturbance of the motor concomitants of emotional affect that is unrelated to mood, recent studies indicate that there may in fact be a correlation. We therefore undertook a study of post-stroke pathological crying in relation to mood score/depression and ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1995.tb00092.x

    authors: Andersen G,Vestergaard K,Ingeman-Nielsen M

    更新日期:1995-03-01 00:00:00

  • Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review.

    abstract:OBJECTIVE:We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS:A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls)...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14638

    authors: Gómez-Garre P,Jesús S,Periñán MT,Adarmes A,Alonso-Canovas A,Blanco-Ollero A,Buiza-Rueda D,Carrillo F,Catalán-Alonso MJ,Del Val J,Escamilla-Sevilla F,Espinosa-Rosso R,Fernández-Moreno MC,García-Moreno JM,García-Ruiz PJ,Giaco

    更新日期:2020-11-11 00:00:00

  • Brainstem progressive multifocal leukoencephalopathy.

    abstract:BACKGROUND AND PURPOSE:Progressive multifocal leukoencephalopathy (PML) is a severe infection caused by the polyomavirus JC that develops in the central nervous system (CNS) of immunosuppressed patients. The infection frequently starts in the brain hemispheres and can spread into other CNS regions such as the brainstem...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14617

    authors: Breville G,Koralnik IJ,Lalive PH

    更新日期:2020-10-30 00:00:00

  • Charcot-Marie-Tooth type X: unusual phenotype of a novel CX32 mutation.

    abstract:BACKGROUND:X-linked Charcot-Marie-Tooth disease (CMTX), caused by mutations in the gene encoding connexin32, is the second most common form of inherited demyelinating neuropathy, next to CMT 1A, and accounts for 10-20% of all hereditary demyelinating neuropathies. AIMS OF THE STUDY:To describe clinical and electrophys...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02263.x

    authors: Mazzeo A,Di Leo R,Toscano A,Muglia M,Patitucci A,Messina C,Vita G

    更新日期:2008-10-01 00:00:00

  • A critical appraisal of randomized controlled trials on intravenous phenytoin in convulsive status epilepticus.

    abstract::Since the 1970s, intravenous (IV) phenytoin (PHT) has traditionally been used as second-stage treatment for convulsive status epilepticus (SE) after failure of benzodiazepines. The aim of this review was to critically assess the evidence supporting the use of IV PHT as treatment of convulsive SE in patients of any age...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/ene.13560

    authors: Brigo F,Bragazzi NL,Lattanzi S,Nardone R,Trinka E

    更新日期:2018-03-01 00:00:00

  • Random forest can predict 30-day mortality of spontaneous intracerebral hemorrhage with remarkable discrimination.

    abstract:BACKGROUND AND PURPOSE:Risk-stratification models based on patient and disease characteristics are useful for aiding clinical decisions and for comparing the quality of care between different physicians or hospitals. In addition, prediction of mortality is beneficial for optimizing resource utilization. We evaluated th...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.02955.x

    authors: Peng SY,Chuang YC,Kang TW,Tseng KH

    更新日期:2010-07-01 00:00:00

  • Anticipatory postural adjustments prior to step initiation are hypometric in untreated Parkinson's disease: an accelerometer-based approach.

    abstract:BACKGROUND AND PURPOSE:Anticipatory postural adjustments (APAs), prior to step initiation, are bradykinetic in advanced Parkinson's disease (PD) and may be one of the factors associated with 'start hesitation'. However, little is known about APAs in the early stage of PD. In this study, we determined whether body-worn ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02641.x

    authors: Mancini M,Zampieri C,Carlson-Kuhta P,Chiari L,Horak FB

    更新日期:2009-09-01 00:00:00

  • A prospective study of "undiagnosed" isolated myelopathy: I. Case selection and clinical features.

    abstract::We aimed to carry out a study of isolated, unexplained myelopathy which avoided as far as possible selection and referral bias. We used a prospective design with case ascertainment from both neurological and neurosurgical referrals. We wanted to establish the sensitivity, predictive value and possible redundancy of cu...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1995.tb00131.x

    authors: Blumhardt LD,Sandercock PA,Moore AP,Woodrow J,Findlay G

    更新日期:1995-09-01 00:00:00

  • Cerebrospinal fluid:serum glucose ratio in the ventricular and lumbar compartments: implications for clinical practice.

    abstract:BACKGROUND AND PURPOSE:Calculation of the cerebrospinal fluid:serum glucose (CSF:SGlu ) ratio is part of the routine cerebrospinal fluid (CSF) work-up. Reference values have been defined for lumbar CSF, but are lacking for ventricular CSF. The objective of this study was to investigate whether the CSF:SGlu ratio is sim...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13513

    authors: Hegen H,Walde J,Auer M,Deisenhammer F

    更新日期:2018-02-01 00:00:00

  • Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon β-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN-β) efficacy could be mediated also by an increase of IGF-1 levels. A 2-year longitudinal study was performed to estimate the prevalence ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13207

    authors: Lanzillo R,Di Somma C,Quarantelli M,Carotenuto A,Pivonello C,Moccia M,Cianflone A,Marsili A,Puorro G,Saccà F,Russo CV,De Luca Picione C,Ausiello F,Colao A,Brescia Morra V

    更新日期:2017-02-01 00:00:00

  • Non-invasive and tracheostomy invasive ventilation in amyotrophic lateral sclerosis: Utilization and survival rates in a cohort study over 12 years in Germany.

    abstract:BACKGROUND AND PURPOSE:The aim of this study was to investigate utilization rates, treatment pathways and survival prognosis in patients with amyotrophic lateral sclerosis (ALS) undergoing non-invasive (NIV) and tracheostomy invasive ventilation (TIV) in a real-world setting. METHODS:A prospective cohort study using a...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14647

    authors: Spittel S,Maier A,Kettemann D,Walter B,Koch B,Krause K,Norden J,Münch C,Meyer T

    更新日期:2020-11-19 00:00:00

  • Lesions to the posterior insular cortex cause dysarthria.

    abstract:BACKGROUND:Up to now, there are few systematic studies in a sufficient number of patients with lesions involving the insular cortex (IC) examining whether damage of the IC is directly related to dysarthria. Thus, this is the first study applying modern voxel-lesion behaviour mapping (VLBM) aimed to examine whether the ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03473.x

    authors: Baier B,zu Eulenburg P,Glassl O,Dieterich M

    更新日期:2011-12-01 00:00:00

  • Overview of magnetic resonance imaging for management of relapsing-remitting multiple sclerosis in everyday practice.

    abstract::Although the value of magnetic resonance imaging (MRI) for diagnosis/differential diagnosis of patients with clinically isolated syndromes suggestive of multiple sclerosis (MS) is widely accepted, adoption of MRI into clinical practice to monitor disease evolution remains a work in progress. However, an accumulating b...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/ene.12800

    authors: Oreja-Guevara C,ParadigMS Group.

    更新日期:2015-10-01 00:00:00