Abstract:
:Since the 1970s, intravenous (IV) phenytoin (PHT) has traditionally been used as second-stage treatment for convulsive status epilepticus (SE) after failure of benzodiazepines. The aim of this review was to critically assess the evidence supporting the use of IV PHT as treatment of convulsive SE in patients of any age. In particular, we critically appraised the results of randomized controlled trials (RCTs) evaluating IV PHT as treatment of convulsive SE. A systematic search of the literature was carried out to identify RCTs evaluating IV PHT as treatment of convulsive SE in patients of any age. Eight RCTs (544 patients allocated to IV PHT) were included. The included studies differed in almost every single characteristic considered. Six RCTs (472 patients) used IV PHT without demonstrating refractoriness of SE to benzodiazepines. Only two RCTs (72 patients) used IV PHT as second-line treatment for benzodiazepine-resistant convulsive SE. Overall, most evidence from RCTs supports the use of IV PHT immediately after IV diazepam, even if seizures have not recurred. The recommendation derived from RCTs supporting the use of IV PHT as second-line treatment in benzodiazepine-resistant convulsive SE is weak. This is emblematic of the lack of robust evidence from large RCTs to inform clinical practice on how to treat SE after failure of first-line drugs. IV PHT given immediately after first-line benzodiazepines could prolong their short antiepileptic effect and prevent seizure recurrence.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Brigo F,Bragazzi NL,Lattanzi S,Nardone R,Trinka Edoi
10.1111/ene.13560subject
Has Abstractpub_date
2018-03-01 00:00:00pages
451-463issue
3eissn
1351-5101issn
1468-1331journal_volume
25pub_type
杂志文章,评审abstract:BACKGROUND AND PURPOSE:Information about metabolic comorbidities in patients with multiple sclerosis (MS) is scarce. Our aim was to examine the prevalence of the metabolic syndrome (MetS) and its components in patients with long duration of MS and significant disability. METHODS:Demographic and clinical data, weight, ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12738
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diagnosis of pharyngeal dysphagia caused by myasthenia gravis (MG) based on clinical examination alone is often challenging. Flexible endoscopic evaluation of swallowing (FEES) combined with Tensilon (edrophonium) application, referred to as the FEES-Tensilon test, was developed to improve diagno...
journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
abstract::The present review of epidemiologic studies on migraine and headache in Europe is part of a larger initiative by the European Brain Council to estimate the costs incurred because of brain disorders. Summarizing the data on 1-year prevalence, the proportion of adults in Europe reporting headache was 51%, migraine 14%, ...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Better understanding the incidence, predictors and mechanisms of early neurological deterioration (END) following intravenous thrombolysis (IVT) for acute stroke with mild symptoms and isolated internal carotid artery occlusion (iICAo) may inform therapeutic decisions. METHODS:From a multicenter...
journal_title:European journal of neurology
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更新日期:2021-02-01 00:00:00
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journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.2009.02894.x
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:European journal of neurology
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abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms, including cognitive deficits. Several magnetic resonance imaging approaches have been applied to investigate brain atrophy in PD. The aim of this study was to detect early structural cortical a...
journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In amyotrophic lateral sclerosis, studies using threshold-tracking transcranial magnetic stimulation (TMS) have identified corticomotoneuronal dysfunction as a key pathogenic mechanism. Some patients, however, display no motor response at maximal TMS intensities, termed here an 'inexcitable' moto...
journal_title:European journal of neurology
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更新日期:2021-01-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12718
更新日期:2015-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1995.tb00131.x
更新日期:1995-09-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12583
更新日期:2015-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14072
更新日期:2020-02-01 00:00:00
abstract::Histamine has a selective affinity for H3-receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology. The objective of this study was to evaluate the therapeutic potential of subcutaneous administration of histamine in migraine prophylaxis, compared with oral administr...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1331.2007.01744.x
更新日期:2007-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13006
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this prospective study was to show and compare the rate of large-fiber involvement with near-nerve needle sensory (NNNS) nerve conduction study (NCS) and with medial plantar NCS recorded with surface electrodes in a group of patients who had clinically pure small-fiber sensory neuropat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02227.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12645
更新日期:2015-04-01 00:00:00
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journal_title:European journal of neurology
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更新日期:2016-04-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. ...
journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02859.x
更新日期:2010-05-01 00:00:00
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journal_title:European journal of neurology
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更新日期:2010-12-01 00:00:00
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journal_title:European journal of neurology
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abstract:BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...
journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13862
更新日期:2019-04-01 00:00:00
abstract::We examined clinical presentations, neuropsychological findings, and perfusion patterns of (99m)Tc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients with early stage dementia with Lewy bodies (DLB) (n = 17) and Parkinson's disease (PD) (n = 16), with age-matched healthy contro...
journal_title:European journal of neurology
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更新日期:2008-01-01 00:00:00