Abstract:
:Histamine has a selective affinity for H3-receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology. The objective of this study was to evaluate the therapeutic potential of subcutaneous administration of histamine in migraine prophylaxis, compared with oral administration of sodium valproate, in an open clinical trial. Ninety-two patients with migraine were selected under criteria established by the International Headache Society and enrolled in a 12-week double-blind controlled clinical trial to evaluate the efficacy of subcutaneous administration of histamine (1-10 ng twice a week; n = 46) compared with oral administration of sodium valproate (500 mg daily dose; n = 46). The variables studied were headache intensity, frequency, duration, analgesic intake and migraine disability assessment (MIDAS). Two-tailed Student's t- test was used to compare means and the Mann-Whitney U and anova tests were used. The data collected during the 4th, 8th and 12th weeks of treatment revealed that histamine caused a significantly greater reduction (P < 0.001) in intensity and duration of migraine attacks as well as in analgesic intake. No difference was detected in the frequency of attacks or in MIDAS. The present study provides evidence of the superior efficacy of histamine applied subcutaneously in migraine prophylaxis when compared with sodium valproate taken orally. Subcutaneously applied histamine may represent a novel and effective therapeutic alternative in resistant migraine patients.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Millán-Guerrero RO,Isais-Millán R,Barreto-Vizcaíno S,Rivera-Castaño L,Garcia-Solorzano A,López-Blanca C,Membrila-Maldonado M,Muñoz-Solis Rdoi
10.1111/j.1468-1331.2007.01744.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
1079-84issue
10eissn
1351-5101issn
1468-1331pii
ENE1744journal_volume
14pub_type
杂志文章,随机对照试验abstract::Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian sym...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2003-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2004-11-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.02956.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12957
更新日期:2016-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1331.2009.02802.x
更新日期:2010-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02331.x
更新日期:2008-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.510103.x
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00605.x
更新日期:2003-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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