Myasthenia and risk of cancer: a population-based case-control study.


BACKGROUND AND PURPOSE:To evaluate the association between having non-thymoma myasthenia and the risk of extra-thymic cancer in a population-based setting. METHODS:A nationwide case-control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer during 2000-2009. Each case was matched by birth year and gender with eight population controls using risk set sampling. Subjects with myasthenia were identified through a validated register-based algorithm. Conditional logistic regression was used to compute crude and adjusted odds ratios (ORs), with 95% confidence intervals (CIs), for cancer associated with a prior diagnosis of myasthenia. RESULTS:In all, 233 437 cases and 1 867 009 controls were identified. A total of 80 cases and 518 controls had a prior diagnosis of myasthenia. Myasthenia was not associated with an increased risk of overall cancer (OR 1.1; 95% CI 0.9-1.4). Adjusted ORs for major cancer sites were also close to unity, whereas an elevated risk of lymphomas was observed (OR 2.0; 95% CI 0.8-5.5). Early-onset myasthenia was associated with a slightly increased OR for overall cancer (1.5; 95% CI 1.0-2.3); however, this estimate was based on small numbers. CONCLUSIONS:Non-thymoma myasthenia was not associated with an increased risk of overall cancer. Larger studies are necessary to evaluate the association between myasthenia and risk of lymphoma and the potential effect modification by age of myasthenia onset in relation to cancer risk.


Eur J Neurol


Pedersen EG,Pottegård A,Hallas J,Friis S,Hansen K,Jensen PE,Gaist D




Has Abstract


2014-05-01 00:00:00












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    abstract:BACKGROUND AND PURPOSE:Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type....

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Song TJ,Kim J,Kim YD,Nam HS,Lee HS,Nam CM,Heo JH

    更新日期:2014-03-01 00:00:00

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    abstract::The aim of the study was to use functional transcranial Doppler to investigate the possibility of revealing different activation patterns during healthy subjects' performance of meaningful and meaningless actions. Mean flow velocity (MFV) changes were recorded in middle cerebral arteries (MCAs) of 26 normal subjects d...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Matteis M,Federico F,Troisi E,Pasqualetti P,Vernieri F,Caltagirone C,Petrosini L,Silvestrini M

    更新日期:2006-01-01 00:00:00

  • Early changes of nerve integrity in preclinical carriers of hereditary transthyretin Ala117Ser amyloidosis with polyneuropathy.

    abstract:BACKGROUND AND PURPOSE:Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers. METHODS:This st...

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    pub_type: 杂志文章


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    更新日期:2020-12-28 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Klingebiel R,Bauknecht HC,Bohner G,Kirsch R,Berger J,Masuhr F

    更新日期:2007-02-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...

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    pub_type: 杂志文章


    authors: Bianchi M,Cosseddu M,Cotelli M,Manenti R,Brambilla M,Rizzetti MC,Padovani A,Borroni B

    更新日期:2015-09-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

    更新日期:1995-09-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Vollono C,Rinalduzzi S,Miliucci R,Vigevano F,Valeriani M

    更新日期:2014-12-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Lebedeva ER,Ushenin AV,Gurary NM,Tsypushkina TS,Gilev DV,Kislyak NV,Olesen J

    更新日期:2020-12-16 00:00:00

  • European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripher

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    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Van den Bergh PY,Hadden RD,Bouche P,Cornblath DR,Hahn A,Illa I,Koski CL,Léger JM,Nobile-Orazio E,Pollard J,Sommer C,van Doorn PA,van Schaik IN,European Federation of Neurological Societies.,Peripheral Nerve Society.

    更新日期:2010-03-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Müller T,Kuhn W,Büttner T,Przuntek H

    更新日期:1999-11-01 00:00:00

  • Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study.

    abstract:BACKGROUND:Elevated total homocysteine (tHcy) levels may be caused by vitamin B12 deficiency and are linked to Alzheimers disease (AD) in some studies, although the evidence is mixed. Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting. OBJECTIVE:To in...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Kivipelto M,Annerbo S,Hultdin J,Bäckman L,Viitanen M,Fratiglioni L,Lökk J

    更新日期:2009-07-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:The role of cardiovascular risk factors in the pathogenesis of cognitive impairment and dementia remains still unclear. We examined the impact of cardiovascular risk factors on cognitive function in a large longitudinal population study. METHODS:Subjects were 5033 stroke-free men and women who p...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Arntzen KA,Schirmer H,Wilsgaard T,Mathiesen EB

    更新日期:2011-05-01 00:00:00

  • Clinical and genetic features of patients with amyotrophic lateral sclerosis in southern China.

    abstract:BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS)-related genes and mutations have been increasingly discovered recently and an improved understanding of genotype-phenotype relationships may help to predict the disease course and refine genetic diagnosis. METHODS:We collected clinical data and blood samples f...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Chen W,Xie Y,Zheng M,Lin J,Huang P,Pei Z,Yao X

    更新日期:2020-06-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究


    authors: Ciolli L,Pescini F,Salvadori E,Del Bene A,Pracucci G,Poggesi A,Nannucci S,Valenti R,Basile AM,Squarzanti F,Bianchi S,Dotti MT,Adriano E,Balestrino M,Federico A,Gandolfo C,Inzitari D,Pantoni L

    更新日期:2014-01-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Schenk T,Walther EU,Mai N

    更新日期:2000-05-01 00:00:00

  • A systematic review of the epidemiology of status epilepticus.

    abstract::Population-based data on the incidence, aetiology, and mortality associated with status epilepticus (SE) are required to develop preventative strategies for SE. Through a systematic review, we aimed to assess the methodological quality as well as similarities, and differences between available population based studies...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审


    authors: Chin RF,Neville BG,Scott RC

    更新日期:2004-12-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:Neuropsychiatric symptoms are commonly observed in neurodegenerative diseases. No biomarker is currently available to diagnose psychiatric conditions. As a consequence, the distinction between psychiatric and neurodegenerative disorders can be challenging in daily practice. METHODS:This retrospe...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Fourier A,Formaglio M,Kaczorowski F,Mollion H,Perret-Liaudet A,Sauvee M,Quadrio I

    更新日期:2020-07-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Asikainen I,Nybo T,Muller K,Sarna S,Kaste M

    更新日期:1999-03-01 00:00:00

  • Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review.

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Gómez-Garre P,Jesús S,Periñán MT,Adarmes A,Alonso-Canovas A,Blanco-Ollero A,Buiza-Rueda D,Carrillo F,Catalán-Alonso MJ,Del Val J,Escamilla-Sevilla F,Espinosa-Rosso R,Fernández-Moreno MC,García-Moreno JM,García-Ruiz PJ,Giaco

    更新日期:2020-11-11 00:00:00

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    pub_type: 杂志文章


    authors: Lin CH,Lin JW,Liu YC,Chang CH,Wu RM

    更新日期:2015-09-01 00:00:00

  • Estradiol levels predict short-term adverse health outcomes in postmenopausal acute stroke women.

    abstract:BACKGROUND:Data on the role of endogenous sex steroids in cerebrovascular disease are sparse. Estradiol is a hormone with diverse actions on the central nervous system. Our aim was to investigate the role of circulating estradiol levels in a postmenopausal acute stroke population. METHODS:During a time-period of 2 yea...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Pappa T,Vemmos K,Mantzou E,Savvari P,Stamatelopoulos K,Alevizaki M

    更新日期:2012-10-01 00:00:00

  • Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease.

    abstract:BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenos...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

    更新日期:2011-05-01 00:00:00

  • Impact of seizures on morbidity and mortality after stroke: a Canadian multi-centre cohort study.

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    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究


    authors: Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

    更新日期:2010-01-01 00:00:00

  • Inflammation, edema and poor outcome are associated with hyperthermia in hypertensive intracerebral hemorrhages.

    abstract:BACKGROUND AND PURPOSE:The deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH et...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Iglesias-Rey R,Rodríguez-Yáñez M,Arias S,Santamaría M,Rodríguez-Castro E,López-Dequidt I,Hervella P,Sobrino T,Campos F,Castillo J

    更新日期:2018-09-01 00:00:00

  • A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg.

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    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究


    authors: Provitera V,Gibbons CH,Wendelschafer-Crabb G,Donadio V,Vitale DF,Stancanelli A,Caporaso G,Liguori R,Wang N,Santoro L,Kennedy WR,Nolano M

    更新日期:2016-02-01 00:00:00

  • Guidelines for treatment of autoimmune neuromuscular transmission disorders.

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    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引


    authors: Skeie GO,Apostolski S,Evoli A,Gilhus NE,Illa I,Harms L,Hilton-Jones D,Melms A,Verschuuren J,Horge HW,European Federation of Neurological Societies.

    更新日期:2010-07-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Jawaid A,Poon M,Strutt AM,Rice LK,McDowell EJ,Salamone AR,Qureshi SU,Simpson E,Appel SH,York MK,Schulz PE

    更新日期:2011-04-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Mazzeo A,Di Leo R,Toscano A,Muglia M,Patitucci A,Messina C,Vita G

    更新日期:2008-10-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Béjot Y,Guilloteau A,Joux J,Lannuzel A,Mimeau E,Mislin-Tritsch C,Fournel I,Bonithon-Kopp C,INDIA Study Group.

    更新日期:2017-05-01 00:00:00

  • Prevalence of renal dysfunction in ischaemic stroke and transient ischaemic attack patients with or without atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...

    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Laible M,Horstmann S,Rizos T,Rauch G,Zorn M,Veltkamp R

    更新日期:2015-01-01 00:00:00