Myasthenia and risk of cancer: a population-based case-control study.

Abstract:

BACKGROUND AND PURPOSE:To evaluate the association between having non-thymoma myasthenia and the risk of extra-thymic cancer in a population-based setting. METHODS:A nationwide case-control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer during 2000-2009. Each case was matched by birth year and gender with eight population controls using risk set sampling. Subjects with myasthenia were identified through a validated register-based algorithm. Conditional logistic regression was used to compute crude and adjusted odds ratios (ORs), with 95% confidence intervals (CIs), for cancer associated with a prior diagnosis of myasthenia. RESULTS:In all, 233 437 cases and 1 867 009 controls were identified. A total of 80 cases and 518 controls had a prior diagnosis of myasthenia. Myasthenia was not associated with an increased risk of overall cancer (OR 1.1; 95% CI 0.9-1.4). Adjusted ORs for major cancer sites were also close to unity, whereas an elevated risk of lymphomas was observed (OR 2.0; 95% CI 0.8-5.5). Early-onset myasthenia was associated with a slightly increased OR for overall cancer (1.5; 95% CI 1.0-2.3); however, this estimate was based on small numbers. CONCLUSIONS:Non-thymoma myasthenia was not associated with an increased risk of overall cancer. Larger studies are necessary to evaluate the association between myasthenia and risk of lymphoma and the potential effect modification by age of myasthenia onset in relation to cancer risk.

journal_name

Eur J Neurol

authors

Pedersen EG,Pottegård A,Hallas J,Friis S,Hansen K,Jensen PE,Gaist D

doi

10.1111/ene.12383

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

773-8

issue

5

eissn

1351-5101

issn

1468-1331

journal_volume

21

pub_type

杂志文章
  • The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients.

    abstract:BACKGROUND AND PURPOSE:Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type....

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12332

    authors: Song TJ,Kim J,Kim YD,Nam HS,Lee HS,Nam CM,Heo JH

    更新日期:2014-03-01 00:00:00

  • Cerebral blood flow velocity changes during meaningful and meaningless gestures--a functional transcranial Doppler study.

    abstract::The aim of the study was to use functional transcranial Doppler to investigate the possibility of revealing different activation patterns during healthy subjects' performance of meaningful and meaningless actions. Mean flow velocity (MFV) changes were recorded in middle cerebral arteries (MCAs) of 26 normal subjects d...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01219.x

    authors: Matteis M,Federico F,Troisi E,Pasqualetti P,Vernieri F,Caltagirone C,Petrosini L,Silvestrini M

    更新日期:2006-01-01 00:00:00

  • Early changes of nerve integrity in preclinical carriers of hereditary transthyretin Ala117Ser amyloidosis with polyneuropathy.

    abstract:BACKGROUND AND PURPOSE:Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers. METHODS:This st...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14698

    authors: Chiang MC,Yeh TY,Sung JY,Hsueh HW,Kao YH,Hsueh SJ,Chang KC,Feng FP,Lin YH,Chao CC,Hsieh ST

    更新日期:2020-12-28 00:00:00

  • Comparative evaluation of 2D time-of-flight and 3D elliptic centric contrast-enhanced MR venography in patients with presumptive cerebral venous and sinus thrombosis.

    abstract::We retrospectively evaluated an elliptic centric ordered 3D (ec 3D) magnetic resonance venography (MRV) technique in comparison to 2D time-of-flight (2D TOF) MRV in patients with presumptive cerebral venous sinus thrombosis (CVST). Twenty-five patients (mean age 40.6 +/- 16.5 years) with presumptive CVST underwent cer...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01574.x

    authors: Klingebiel R,Bauknecht HC,Bohner G,Kirsch R,Berger J,Masuhr F

    更新日期:2007-02-01 00:00:00

  • Left parietal cortex transcranial direct current stimulation enhances gesture processing in corticobasal syndrome.

    abstract:BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12748

    authors: Bianchi M,Cosseddu M,Cotelli M,Manenti R,Brambilla M,Rizzetti MC,Padovani A,Borroni B

    更新日期:2015-09-01 00:00:00

  • A clinical variance in familial amyotrophic lateral sclerosis with a point mutation in Cu/Zn superoxide dismutase gene.

    abstract::We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). In this family, the age at onset was young (28.0 ± 3.8 years old, mean ± SD, n = 4) a...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1995.tb00141.x

    authors: Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

    更新日期:1995-09-01 00:00:00

  • Somatosensory system hyperexcitability in alternating hemiplegia of childhood.

    abstract:BACKGROUND AND PURPOSE:Alternating hemiplegia of childhood (AHC) is a rare neurological disease characterized by recurrent paroxysmal attacks of hemiplegia. The aim of the study was to assess the recovery cycle of the somatosensory evoked potentials (SEPs) in a group of AHC patients. METHODS:Seven AHC patients and 10 ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12516

    authors: Vollono C,Rinalduzzi S,Miliucci R,Vigevano F,Valeriani M

    更新日期:2014-12-01 00:00:00

  • Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors.

    abstract::No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiol...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14684

    authors: Lebedeva ER,Ushenin AV,Gurary NM,Tsypushkina TS,Gilev DV,Kislyak NV,Olesen J

    更新日期:2020-12-16 00:00:00

  • European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripher

    abstract:BACKGROUND:Consensus guidelines on the definition, investigation, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been previously published in European Journal of Neurology and Journal of the Peripheral Nervous System. OBJECTIVES:To revise these guidelines. METHODS:Disease exper...

    journal_title:European journal of neurology

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1111/j.1468-1331.2009.02930.x

    authors: Van den Bergh PY,Hadden RD,Bouche P,Cornblath DR,Hahn A,Illa I,Koski CL,Léger JM,Nobile-Orazio E,Pollard J,Sommer C,van Doorn PA,van Schaik IN,European Federation of Neurological Societies.,Peripheral Nerve Society.

    更新日期:2010-03-01 00:00:00

  • Colour vision abnormalities and movement time in Parkinson's disease.

    abstract::Visual system dysfunction has been reported in Parkinson's disease (PD). The objective of the present study was to evaluate a putative association of distorted colour vision and delayed initiation and execution of movement in PD. We performed the Farnsworth-Munsell 100-hue test and estimated the total error score in 3...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1999.660711.x

    authors: Müller T,Kuhn W,Büttner T,Przuntek H

    更新日期:1999-11-01 00:00:00

  • Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study.

    abstract:BACKGROUND:Elevated total homocysteine (tHcy) levels may be caused by vitamin B12 deficiency and are linked to Alzheimers disease (AD) in some studies, although the evidence is mixed. Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting. OBJECTIVE:To in...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02590.x

    authors: Kivipelto M,Annerbo S,Hultdin J,Bäckman L,Viitanen M,Fratiglioni L,Lökk J

    更新日期:2009-07-01 00:00:00

  • Impact of cardiovascular risk factors on cognitive function: the Tromsø study.

    abstract:BACKGROUND AND PURPOSE:The role of cardiovascular risk factors in the pathogenesis of cognitive impairment and dementia remains still unclear. We examined the impact of cardiovascular risk factors on cognitive function in a large longitudinal population study. METHODS:Subjects were 5033 stroke-free men and women who p...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03263.x

    authors: Arntzen KA,Schirmer H,Wilsgaard T,Mathiesen EB

    更新日期:2011-05-01 00:00:00

  • Clinical and genetic features of patients with amyotrophic lateral sclerosis in southern China.

    abstract:BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS)-related genes and mutations have been increasingly discovered recently and an improved understanding of genotype-phenotype relationships may help to predict the disease course and refine genetic diagnosis. METHODS:We collected clinical data and blood samples f...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14213

    authors: Chen W,Xie Y,Zheng M,Lin J,Huang P,Pei Z,Yao X

    更新日期:2020-06-01 00:00:00

  • Influence of vascular risk factors and neuropsychological profile on functional performances in CADASIL: results from the MIcrovascular LEukoencephalopathy Study (MILES).

    abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease that may lead to disability and whose phenotype modulators are still unknown. METHODS:In the MIcrovascular LEukoencephalopathy Study (MILES), we asse...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ene.12241

    authors: Ciolli L,Pescini F,Salvadori E,Del Bene A,Pracucci G,Poggesi A,Nannucci S,Valenti R,Basile AM,Squarzanti F,Bianchi S,Dotti MT,Adriano E,Balestrino M,Federico A,Gandolfo C,Inzitari D,Pantoni L

    更新日期:2014-01-01 00:00:00

  • Closed- and open-loop handwriting performance in patients with multiple sclerosis.

    abstract::Normal subjects use an open-loop motor control strategy in handwriting, but they are able to switch to closed-loop motor control when the demands on accuracy increase. These closed-loop handwriting movements of normal subjects resemble the inefficient movements found in writing-impaired patients. The hypothesis that s...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2000.00068.x

    authors: Schenk T,Walther EU,Mai N

    更新日期:2000-05-01 00:00:00

  • A systematic review of the epidemiology of status epilepticus.

    abstract::Population-based data on the incidence, aetiology, and mortality associated with status epilepticus (SE) are required to develop preventative strategies for SE. Through a systematic review, we aimed to assess the methodological quality as well as similarities, and differences between available population based studies...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2004.00943.x

    authors: Chin RF,Neville BG,Scott RC

    更新日期:2004-12-01 00:00:00

  • A combination of total tau and neurofilaments discriminates between neurodegenerative and primary psychiatric disorders.

    abstract:BACKGROUND AND PURPOSE:Neuropsychiatric symptoms are commonly observed in neurodegenerative diseases. No biomarker is currently available to diagnose psychiatric conditions. As a consequence, the distinction between psychiatric and neurodegenerative disorders can be challenging in daily practice. METHODS:This retrospe...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14247

    authors: Fourier A,Formaglio M,Kaczorowski F,Mollion H,Perret-Liaudet A,Sauvee M,Quadrio I

    更新日期:2020-07-01 00:00:00

  • Speed performance and long-term functional and vocational outcome in a group of young patients with moderate or severe traumatic brain injury.

    abstract::We studied specific aspects of speed performance in neuropsychological tests and functional and vocational long-term outcome among moderate or severe traumatic brain injury (TBI) patients admitted to a rehabilitation programme. A group of 140 patients with mild, moderate or severe TBI was followed up for a minimum of ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1999.tb00011.x

    authors: Asikainen I,Nybo T,Muller K,Sarna S,Kaste M

    更新日期:1999-03-01 00:00:00

  • Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review.

    abstract:OBJECTIVE:We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS:A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls)...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14638

    authors: Gómez-Garre P,Jesús S,Periñán MT,Adarmes A,Alonso-Canovas A,Blanco-Ollero A,Buiza-Rueda D,Carrillo F,Catalán-Alonso MJ,Del Val J,Escamilla-Sevilla F,Espinosa-Rosso R,Fernández-Moreno MC,García-Moreno JM,García-Ruiz PJ,Giaco

    更新日期:2020-11-11 00:00:00

  • Risk of Parkinson's disease following anxiety disorders: a nationwide population-based cohort study.

    abstract:BACKGROUND AND PURPOSE:Anxiety is potentially a pre-motor symptom of Parkinson's disease (PD). Our aim was to investigate the association between anxiety and subsequent PD risk in a population-based sample. METHODS:A total of 174 776 participants, who were free of prior PD, dementia and stroke, were enrolled from Taiw...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12740

    authors: Lin CH,Lin JW,Liu YC,Chang CH,Wu RM

    更新日期:2015-09-01 00:00:00

  • Estradiol levels predict short-term adverse health outcomes in postmenopausal acute stroke women.

    abstract:BACKGROUND:Data on the role of endogenous sex steroids in cerebrovascular disease are sparse. Estradiol is a hormone with diverse actions on the central nervous system. Our aim was to investigate the role of circulating estradiol levels in a postmenopausal acute stroke population. METHODS:During a time-period of 2 yea...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2012.03714.x

    authors: Pappa T,Vemmos K,Mantzou E,Savvari P,Stamatelopoulos K,Alevizaki M

    更新日期:2012-10-01 00:00:00

  • Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease.

    abstract:BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenos...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03262.x

    authors: Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

    更新日期:2011-05-01 00:00:00

  • Impact of seizures on morbidity and mortality after stroke: a Canadian multi-centre cohort study.

    abstract:INTRODUCTION:Limited information is available about the impact of seizures on stroke outcome, health care delivery and resource utilization. OBJECTIVE:To determine whether the presence of seizures after stroke increases disability, mortality and health care utilization (length of hospital stay, ICU admission, consults...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1468-1331.2009.02739.x

    authors: Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

    更新日期:2010-01-01 00:00:00

  • Inflammation, edema and poor outcome are associated with hyperthermia in hypertensive intracerebral hemorrhages.

    abstract:BACKGROUND AND PURPOSE:The deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH et...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13677

    authors: Iglesias-Rey R,Rodríguez-Yáñez M,Arias S,Santamaría M,Rodríguez-Castro E,López-Dequidt I,Hervella P,Sobrino T,Campos F,Castillo J

    更新日期:2018-09-01 00:00:00

  • A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg.

    abstract:BACKGROUND AND PURPOSE:Quantification of intraepidermal nerve fibers (IENFs) in skin biopsies is now the tool of choice to diagnose small fiber neuropathies. An adequate normative dataset, necessary to assess normality cutoffs, is available for brightfield microscopy but not for immunofluorescence. METHODS:Intraepider...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ene.12842

    authors: Provitera V,Gibbons CH,Wendelschafer-Crabb G,Donadio V,Vitale DF,Stancanelli A,Caporaso G,Liguori R,Wang N,Santoro L,Kennedy WR,Nolano M

    更新日期:2016-02-01 00:00:00

  • Guidelines for treatment of autoimmune neuromuscular transmission disorders.

    abstract:BACKGROUND:Important progress has been made in our understanding of the autoimmune neuromuscular transmission (NMT) disorders; myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS) and neuromyotonia (Isaacs' syndrome). METHODS:To prepare consensus guidelines for the treatment of the autoimmune NMT disorders...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1468-1331.2010.03019.x

    authors: Skeie GO,Apostolski S,Evoli A,Gilhus NE,Illa I,Harms L,Hilton-Jones D,Melms A,Verschuuren J,Horge HW,European Federation of Neurological Societies.

    更新日期:2010-07-01 00:00:00

  • Does apolipoprotein E genotype modify the clinical expression of ALS?

    abstract:BACKGROUND:The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (AL...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03225.x

    authors: Jawaid A,Poon M,Strutt AM,Rice LK,McDowell EJ,Salamone AR,Qureshi SU,Simpson E,Appel SH,York MK,Schulz PE

    更新日期:2011-04-01 00:00:00

  • Charcot-Marie-Tooth type X: unusual phenotype of a novel CX32 mutation.

    abstract:BACKGROUND:X-linked Charcot-Marie-Tooth disease (CMTX), caused by mutations in the gene encoding connexin32, is the second most common form of inherited demyelinating neuropathy, next to CMT 1A, and accounts for 10-20% of all hereditary demyelinating neuropathies. AIMS OF THE STUDY:To describe clinical and electrophys...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02263.x

    authors: Mazzeo A,Di Leo R,Toscano A,Muglia M,Patitucci A,Messina C,Vita G

    更新日期:2008-10-01 00:00:00

  • Social deprivation and stroke severity on admission: a French cohort study in Burgundy and the West Indies - Guyana region.

    abstract:BACKGROUND AND PURPOSE:Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13271

    authors: Béjot Y,Guilloteau A,Joux J,Lannuzel A,Mimeau E,Mislin-Tritsch C,Fournel I,Bonithon-Kopp C,INDIA Study Group.

    更新日期:2017-05-01 00:00:00

  • Prevalence of renal dysfunction in ischaemic stroke and transient ischaemic attack patients with or without atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12528

    authors: Laible M,Horstmann S,Rizos T,Rauch G,Zorn M,Veltkamp R

    更新日期:2015-01-01 00:00:00