Abstract:
BACKGROUND AND PURPOSE:To evaluate the association between having non-thymoma myasthenia and the risk of extra-thymic cancer in a population-based setting. METHODS:A nationwide case-control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer during 2000-2009. Each case was matched by birth year and gender with eight population controls using risk set sampling. Subjects with myasthenia were identified through a validated register-based algorithm. Conditional logistic regression was used to compute crude and adjusted odds ratios (ORs), with 95% confidence intervals (CIs), for cancer associated with a prior diagnosis of myasthenia. RESULTS:In all, 233 437 cases and 1 867 009 controls were identified. A total of 80 cases and 518 controls had a prior diagnosis of myasthenia. Myasthenia was not associated with an increased risk of overall cancer (OR 1.1; 95% CI 0.9-1.4). Adjusted ORs for major cancer sites were also close to unity, whereas an elevated risk of lymphomas was observed (OR 2.0; 95% CI 0.8-5.5). Early-onset myasthenia was associated with a slightly increased OR for overall cancer (1.5; 95% CI 1.0-2.3); however, this estimate was based on small numbers. CONCLUSIONS:Non-thymoma myasthenia was not associated with an increased risk of overall cancer. Larger studies are necessary to evaluate the association between myasthenia and risk of lymphoma and the potential effect modification by age of myasthenia onset in relation to cancer risk.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Pedersen EG,Pottegård A,Hallas J,Friis S,Hansen K,Jensen PE,Gaist Ddoi
10.1111/ene.12383subject
Has Abstractpub_date
2014-05-01 00:00:00pages
773-8issue
5eissn
1351-5101issn
1468-1331journal_volume
21pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Better understanding the incidence, predictors and mechanisms of early neurological deterioration (END) following intravenous thrombolysis (IVT) for acute stroke with mild symptoms and isolated internal carotid artery occlusion (iICAo) may inform therapeutic decisions. METHODS:From a multicenter...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14541
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with the cerebellar variant of multiple system atrophy (MSA-C) often show cognitive deficits in various cognitive domains. The association between morphometric changes in cortical and subcortical structures and cognitive impairments in MSA-C were investigated to explore the neural correl...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12796
更新日期:2016-01-01 00:00:00
abstract::No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiol...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14684
更新日期:2020-12-16 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13862
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric in...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14611
更新日期:2020-10-24 00:00:00
abstract::The Mini-Mental State Examination (MMSE), a brief test to assess cognitive status, is heavily influenced by age and education. It was administered to 1019 elderly subjects (aged 65-89 years) living in three different Italian cities. A statistical non-linear regression model was built up in order to obtain adjustment c...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1996.tb00423.x
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:High levels of glutamic acid decarboxylase (GAD)-ab were initially described in patients with stiff person syndrome, and have since also been observed in patients with other neurological diseases. Temporal lobe epilepsy (TLE) seems to be specially associated. Our purpose is to describe the preval...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03609.x
更新日期:2012-06-01 00:00:00
abstract::Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2006.01411.x
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV di...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02337.x
更新日期:2009-01-01 00:00:00
abstract::While pathological crying has classically been described as a disturbance of the motor concomitants of emotional affect that is unrelated to mood, recent studies indicate that there may in fact be a correlation. We therefore undertook a study of post-stroke pathological crying in relation to mood score/depression and ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1995.tb00092.x
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14215
更新日期:2020-07-01 00:00:00
abstract::Cortical excitability of the primary motor cortex is altered in patients with Parkinson's disease (PD). Therefore, modulation of cortical excitability by high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex might result in beneficial effects on motor functions in PD. The present study...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1468-1331.2003.00649.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS:A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls)...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14638
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND AND PURPOSE:To assess the efficacy and safety of olesoxime, a molecule with neuroprotective properties, in patients with amyotrophic lateral sclerosis (ALS) treated with riluzole. METHODS:A double-blind, randomized, placebo-controlled, multicenter trial of 18 months' duration was conducted in 512 subjects, ...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12344
更新日期:2014-03-01 00:00:00
abstract::Eur J Neurol 6:113 Copyright Lippincott Williams & Wilkins ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1999.tb00001.x
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study investigated whether incompleteness of the anterior part of the circle of Willis affects the occurrence of lacunes in the basal ganglia. METHODS:One thousand and seventy-seven healthy individuals examined by magnetic resonance (MR) imaging and MR angiography were divided into eight su...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03400.x
更新日期:2011-11-01 00:00:00
abstract::At least 13 different disease entities affecting the central nervous system, peripheral nervous system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 (IgG4) immune reactivity. IgG4 has always been considered a benign, non-inflammatory subclass of IgG, in contrast to the well-known c...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.12758
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Alternating hemiplegia of childhood (AHC) is a rare neurological disease characterized by recurrent paroxysmal attacks of hemiplegia. The aim of the study was to assess the recovery cycle of the somatosensory evoked potentials (SEPs) in a group of AHC patients. METHODS:Seven AHC patients and 10 ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12516
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02850.x
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Depigmentation of the substantia nigra (SN) and locus coeruleus (LC) is a conspicuous pathological feature of Parkinson's disease (PD) and is related to the loss of neuromelanin, whose paramagnetic properties result in high signal on specific T1-weighted magnetic resonance imaging (MRI). Recent studies have ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12613
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improved biomarkers are needed to facilitate clinical decision-making and as surrogate endpoints in clinical trials in multiple sclerosis (MS). We assessed whether neurodegenerative and neuroinflammatory markers in cerebrospinal fluid (CSF) at initial sampling could predict disease activity durin...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13274
更新日期:2017-05-01 00:00:00
abstract::Digital subtraction angiography (DSA) is considered to be the 'gold standard' for confirmation of severe (70-99%) stenoses of internal carotid arteries (ICAs). However, it is associated with a risk of complications. The aim of this study was to assess the accuracy of ultrasonography (US), computed tomographic angiogra...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1331.2004.00878.x
更新日期:2004-11-01 00:00:00
abstract::There is paucity of studies on predictors of long-term sequelae of tuberculous meningitis (TBM). We report the neurological sequelae of TBM at 1 year and their predictors. Patients with TBM who were followed up for 1 year were included. The diagnosis of TBM was based on clinical, cerebrospinal fluid (CSF) and computed...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01534.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and solubl...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14500
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. METHODS: We conducted a population-based cohort study using the General Practice Research D...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03668.x
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Patients with Parkinson's disease (PD) and chronically treated with L-DOPA exhibit, in a percentage of 10-30%, supra-physiological levels of plasma total homocysteinemia (tHcy). In this study, we have investigated, in a group of hyper-homocysteinemic PD patients, the time of hyper-tHcy recurrence after disco...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02894.x
更新日期:2010-05-01 00:00:00
abstract::The presence of white matter lesions (WML) is an important prognostic factor for the development of stroke. Plasma total homocysteine (tHcy), which increases with diabetes, has been flagged as a novel predictor for cerebrovascular events. We tested the hypothesis that the presence of WML correlates with tHcy and insul...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02062.x
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms, including cognitive deficits. Several magnetic resonance imaging approaches have been applied to investigate brain atrophy in PD. The aim of this study was to detect early structural cortical a...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12785
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is a hereditary disorder of mitochondrial long-chain fatty acid oxidation that has variable presentations, including exercise intolerance, cardiomyopathy and liver disease. The aim of this study was to describe the clinical and genetic ma...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14402
更新日期:2020-11-01 00:00:00
abstract::In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2006.01447.x
更新日期:2006-02-01 00:00:00