Abstract:
:In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian syndromes, motor neuron disease and cerebral palsy. The toxin can be injected blindly based on anatomic landmarks of the salivary glands, or localization can be facilitated by use of ultrasound guidance. There are few reported adverse effects. However, many more carefully designed, controlled studies are still required to address the specific questions related to selection of patients, the optimal injection technique, the appropriate dose of botulinum toxin and its long-term effects.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Tan EKdoi
10.1111/j.1468-1331.2006.01447.xsubject
Has Abstractpub_date
2006-02-01 00:00:00pages
60-4eissn
1351-5101issn
1468-1331pii
ENE1447journal_volume
13 Suppl 1pub_type
杂志文章,评审abstract:INTRODUCTION:An association between parental smoking and multiple sclerosis (MS) in offspring has been reported. This study examined whether maternal smoking during pregnancy is associated with MS in offspring. METHODS:Swedish general population registers provided prospectively recorded information on maternal smoking...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02331.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:X-linked Charcot-Marie-Tooth disease (CMTX), caused by mutations in the gene encoding connexin32, is the second most common form of inherited demyelinating neuropathy, next to CMT 1A, and accounts for 10-20% of all hereditary demyelinating neuropathies. AIMS OF THE STUDY:To describe clinical and electrophys...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02263.x
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The incidence of hospitalizations, treatment and case fatality of ischaemic stroke were assessed utilizing a comprehensive multinational database to attempt to compare the healthcare systems in six European countries, aiming also to identify the limitations and make suggestions for future improve...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12560
更新日期:2015-02-01 00:00:00
abstract::Frontotemporal dementia (FTD) often presents with behavioural changes warranting treatment with antipsychotic medications. It is known that patients with Lewy body dementia are sensitive to developing extrapyramidal symptoms (EPS) from these medications. This has not been emphasized in FTD. We report three patients wi...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.02032.x
更新日期:2008-02-01 00:00:00
abstract::Post-marketing surveillance studies are needed to assess the long-term safety, compliance and clinical efficacy of interferon beta-1a (IFNbeta-1a) therapy in multiple sclerosis (MS) patients. The goals of this study were to (i) assess the safety, compliance and clinical efficacy of long-term intramuscular (i.m.) IFNbe...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1468-1331.2006.01422.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS:A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls)...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14638
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The ataxias are a challenging group of neurological diseases due the aetiological heterogeneity and the complexity of the genetic subtypes. This guideline focuses on the heredodegenerative ataxias. The aim is to provide a peer-reviewed evidence-based guideline for clinical neurologists and oth...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12341
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improved biomarkers are needed to facilitate clinical decision-making and as surrogate endpoints in clinical trials in multiple sclerosis (MS). We assessed whether neurodegenerative and neuroinflammatory markers in cerebrospinal fluid (CSF) at initial sampling could predict disease activity durin...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13274
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Spastic pes equinovarus is a frequent pathological posture of the lower extremity. Botulinum toxin (BoNT/A) has been successfully applied to treat lower limb spasticity. However, the best time to initiate treatment remains unclear. A beneficial effect of an early treatment has been suggested in p...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12381
更新日期:2014-08-01 00:00:00
abstract::There are at least seven clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP). In this study we investigated electrophysiological characteristics in patients with ADPSP linked to chromosome 2p (SPG4). Twelve patients from six different families with ADPSP l...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00249.x
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:A Task Force was convened by the EFNS/MDS-ES Scientist Panel on Parkinson's disease (PD) and other movement disorders to systemically review relevant publications on the diagnosis of PD. METHODS:Following the EFNS instruction for the preparation of neurological diagnostic guidelines, recommendation levels h...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.12022
更新日期:2013-01-01 00:00:00
abstract::Painful diabetic peripheral neuropathy (DPN) is described as a superficial burning pain associated with other positive and/or negative sensory systems affecting the feet and lower extremities. It is one of the most commonly encountered neuropathic pain syndromes in clinical practice. Presentation may be complicated by...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1471-0552.2004.00795.x
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported that certain optical coherence tomography (OCT) measures were sensitive and reliable in identifying idiopathic intracranial hypertension (IIH). This prospective study aimed to define OCT measures that allow differentiation of IIH with and without papilledema, thereby helpin...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13893
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Consensus guidelines on the definition, investigation, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been previously published in European Journal of Neurology and Journal of the Peripheral Nervous System. OBJECTIVES:To revise these guidelines. METHODS:Disease exper...
journal_title:European journal of neurology
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1111/j.1468-1331.2009.02930.x
更新日期:2010-03-01 00:00:00
abstract::The natural history of thymoma remains unpredictable because of the possibility of recurrence not infrequent after resection, but generally confined to the mediastinum Rufini et al. (1997). ...
journal_title:European journal of neurology
pub_type: 信件
doi:10.1046/j.1468-1331.2000.00023.x
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim was to study the prevalence of epilepsy in a hospital-based systemic lupus erythematosus (SLE) cohort and to investigate the relationship between epilepsy and other manifestations of neuropsychiatric SLE (NPSLE). METHODS:The study population consisted of 440 SLE patients recruited from 1...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14077
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Acute severe exacerbations of myasthenia gravis (MG) are common in both early and late onset MG. We wished to examine the current management in the intensive care unit (ICU) of severe exacerbations of MG and to study the long-term prognosis of MG following discharge from the ICU. METHODS:We retr...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12115
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institute for Health and Care Excellence (NICE) in the UK recommends the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service. In view of the lack of data on the efficacy of this therapy...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13657
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose was to report the results of ultrasound-guided lumbar puncture for the administration of nusinersen in spinal muscular atrophy (SMA) patients with complex spines. METHODS:Eighteen SMA patients (five children, five adolescents and eight adults) with either severe scoliosis or spondylo...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14586
更新日期:2021-02-01 00:00:00
abstract::Although migraine is a neurovascular disorder, both scalp tenderness and referred pain have been observed in migraine patients. The present study was carried out to investigate the presence of trigger points eliciting referred pain in 98 migraine patients and in 32 healthy subjects. Trigger points were found in 92 (93...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01181.x
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Anosognosia refers to a deficit of self-awareness or impaired insight for cognitive and behavioral problems. Cognitive anosognosia was explored in de novo patients with Parkinson's disease (PD) and its relationship to cognitive function and neuropsychiatric symptoms was investigated. METHODS:The...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14188
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim was to identify early imaging surrogate markers of clinical progression in patients after the first demyelinating event suggestive of multiple sclerosis treated with weekly intramuscular interferon β-1a. In a prospective observational study, the predictive role of baseline and 6-month cha...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12716
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In contrast to anterior circulation stroke (ACS), there is no evidence from randomized trials that mechanical thrombectomy (MT) with modern stent retrievers or thromboaspiration is safe and effective in posterior circulation stroke (PCS). METHODS:The present analysis was based on the prospective...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13809
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12645
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Important progress has been made in our understanding of the autoimmune neuromuscular transmission (NMT) disorders; myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS) and neuromyotonia (Isaacs' syndrome). METHODS:To prepare consensus guidelines for the treatment of the autoimmune NMT disorders...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2010.03019.x
更新日期:2010-07-01 00:00:00
abstract::Complex painful reflex syndrome is sometimes described in the chronic phase of stroke. Acute autonomic dysfunction (AAD), which is occasionally present in cases of acute stroke, has not been studied prospectively. The aim of the study was to investigate AAD on the hemibody contralateral to the lesion in the acute phas...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01488.x
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The relative frequency of the different autosomal dominant cerebellar ataxia (ADCA) varies widely amongst different geographic locations. Here we describe a series of 45 ADCA families from Portugal. METHODS:Patients with progressive cerebellar dysfunction of autosomal dominant transmission under...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02757.x
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Antecedent surgery has been described to trigger Guillain-Barré syndrome (GBS), but its evidence is poor and based on case reports only. METHODS:We performed a retrospective analysis of 63 patients with GBS admitted to the University Hospital Basel and University Children's Hospital Basel from J...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03730.x
更新日期:2012-09-01 00:00:00
abstract::Myeloproliferative disorders (MPD) are associated with an increased risk for thrombembolic events. In this study, we examined the prognostic value of transcranial Doppler (TCD) microemboli detection regarding clinical events and correlated TCD findings with results of blood cell counts and platelet flow cytometry to g...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01616.x
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV di...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02337.x
更新日期:2009-01-01 00:00:00