Association of incompleteness of the anterior part of the circle of Willis with the occurrence of lacunes in the basal ganglia.

abstract：BACKGROUND:Cognitive tests are known to be influenced by language, culture and education. In addition, there may be an impact of 'epoch' in cognition, because there is secular increase in scores of IQ tests in children. If we assume this is a long lasting process, then it should persist later in life. METHODS:To test ...

journal_title：European journal of neurology

authors： Morgado J,Rocha CS,Maruta C,Guerreiro M,Martins IP

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenos...

journal_title：European journal of neurology

authors： Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

更新日期：2011-05-01 00:00:00

abstract：:Levodopa-carbidopa (LD) in low dosages adequately controls symptoms in most patients with Parkinson's disease and delays the appearance of fluctuations and dyskinesias. It has been suggested that early combination therapy with bromocriptine and levodopa delays or prevents the onset of late treatment complication assoc...

journal_title：European journal of neurology

authors： Alarcon F,Cevallos N,Lees AJ

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...

journal_title：European journal of neurology

authors： Schapira AH,Barone P,Hauser RA,Mizuno Y,Rascol O,Busse M,Debieuvre C,Fraessdorf M,Poewe W

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment is common in Parkinson's disease (PD), even in the early stages. We aimed to assess the relationship between insulin-like growth factor-1 (IGF-1) and cognitive functions in early, drug-naïve patients with PD. METHODS:Serum IGF-1 was measured in 65 early, drug-naïve patients ...

journal_title：European journal of neurology

authors： Pellecchia MT,Santangelo G,Picillo M,Pivonello R,Longo K,Pivonello C,Vitale C,Amboni M,De Rosa A,Moccia M,Erro R,De Michele G,Santoro L,Colao A,Barone P

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The involvement of metabolic factors in the development of dementia has received much attention. However, previous studies have yielded conflicting results regarding how blood adipocytokine level impacts cognitive decline and dementia. This study aimed to clarify whether serum high-molecular-weig...

journal_title：European journal of neurology

authors： Kitagawa K,Miwa K,Okazaki S,Sakaguchi M,Mochizuki H

更新日期：2016-03-01 00:00:00

abstract：:Myeloproliferative disorders (MPD) are associated with an increased risk for thrombembolic events. In this study, we examined the prognostic value of transcranial Doppler (TCD) microemboli detection regarding clinical events and correlated TCD findings with results of blood cell counts and platelet flow cytometry to g...

journal_title：European journal of neurology

authors： Weber CA,Matzdorff AC,Gerriets T,Villmow T,Stolz E

更新日期：2007-02-01 00:00:00

abstract：:We report on a patient who presented with isolated transient headache as the only manifestation of pituitary apoplexy. A high index of suspicion and MRI led to the diagnosis. Copyright 1998 Lippincott Williams & Wilkins ...

journal_title：European journal of neurology

authors： Hernandez A,Angeles Del Real M,Aguirre M,Vaamonde J,Gudin M,Ibanez R

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...

journal_title：European journal of neurology

authors： Carli G,Caminiti SP,Galbiati A,Marelli S,Casoni F,Padovani A,Ferini-Strambi L,Perani D

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Many patients with multiple sclerosis (MS) present swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, has a profound impact on the quality of life but is under-reported by patients. The objective was to investigate the psychometric properties of the Dysphag...

journal_title：European journal of neurology

authors： Printza A,Boziki M,Bakirtzis C,Nikolaidis I,Kalaitzi M,Triaridis S,Grigoriadis N

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients suffering from basilar artery occlusion (BAO) and treated with intravenous thrombolysis are, in some centers, started on adjunct anticoagulation in hyperacute settings. We aimed to assess the outcome of such patients and to compare low-molecular weight heparin (LMWH) and unfractionated h...

journal_title：European journal of neurology

authors： Ritvonen J,Strbian D,Silvennoinen H,Virtanen P,Salonen O,Lindsberg PJ,Sairanen T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ataxia-telangiectasia (A-T) is a rare neurodegenerative disease, due to A-T mutated (ATM) gene mutations, which typically presents with signs of progressive neurological dysfunction, cerebellar ataxia and uncoordinated movements. A-T severely affects patients' quality of life. Successful treatmen...

journal_title：European journal of neurology

authors： Cirillo E,Del Giudice E,Micheli R,Cappellari AM,Soresina A,Dellepiane RM,Pietrogrande MC,Dell'Era L,Specchia F,Pession A,Plebani A,Pignata C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:  A low ankle-brachial index (ABI) is predictive of peripheral arterial disease (PAD). For unknown reasons, patients with PAD demonstrate higher vascular mortality during follow-up than do those without. Initial stroke severity is a strong predictor of long-term outcome and may be different between patients ...

journal_title：European journal of neurology

authors： Lee DH,Kim J,Lee HS,Cha MJ,Kim YD,Nam HS,Nam CM,Heo JH

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare inflammatory demyelinating disorders of the central nervous system. The identification of specific antibodies directed to aquaporin 4 (AQP4-IgG) led to the distinction from multiple sclerosis. However, up to 25% of the clinicall...

journal_title：European journal of neurology

authors： van Pelt ED,Wong YY,Ketelslegers IA,Hamann D,Hintzen RQ

更新日期：2016-03-01 00:00:00

abstract：:Visual recognition memory was assessed in terms of delay duration, memory load and amount of interference(s) in non-demented patients with Parkinson's disease (PD) using an automated delayed non-matching-to-sample (DNMS) task with trial-unique stimuli. Special attention was focused on the different cognitive functions...

journal_title：European journal of neurology

authors： Blanchet S,Marié RM,Dauvillier F,Landeau B,Benali K,Eustache F,Chavoix C

更新日期：2000-09-01 00:00:00

abstract：:Normal subjects use an open-loop motor control strategy in handwriting, but they are able to switch to closed-loop motor control when the demands on accuracy increase. These closed-loop handwriting movements of normal subjects resemble the inefficient movements found in writing-impaired patients. The hypothesis that s...

journal_title：European journal of neurology

authors： Schenk T,Walther EU,Mai N

更新日期：2000-05-01 00:00:00

abstract：:Eur J Neurol 6:113 Copyright Lippincott Williams & Wilkins ...

journal_title：European journal of neurology

authors： Boller F,Petrov AM

更新日期：1999-03-01 00:00:00

abstract：:Allodynia--perception of pain from non-noxious stimuli--is a common clinical feature in various pain syndromes. The significance for migraine has increasingly been recognized and the pathophysiology has been investigated in detail. Allodynia is a marker for sensitization of central trigeminal neurons. Intensity and pe...

journal_title：European journal of neurology

authors： Schürks M,Diener HC

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Depressed mood is a common psychiatric problem associated with Parkinson's disease (PD), and studies have suggested a benefit of rasagiline treatment. METHODS:ACCORDO (see the ) was a 12-week, double-blind, placebo-controlled trial to evaluate the effects of rasagiline 1 mg/day on depressive sym...

journal_title：European journal of neurology

authors： Barone P,Santangelo G,Morgante L,Onofrj M,Meco G,Abbruzzese G,Bonuccelli U,Cossu G,Pezzoli G,Stanzione P,Lopiano L,Antonini A,Tinazzi M

更新日期：2015-08-01 00:00:00

abstract：:To determine whether changes in specific regions of the brain can contribute to the development of depression in patients with multiple sclerosis (MS). We prospectively studied 90 patients with clinically definite MS. Disability, independence, cognitive performances, and depressive and anxiety symptoms have been asses...

journal_title：European journal of neurology

authors： Zorzon M,Zivadinov R,Nasuelli D,Ukmar M,Bratina A,Tommasi MA,Mucelli RP,Brnabic-Razmilic O,Grop A,Bonfigli L,Cazzato G

更新日期：2002-09-01 00:00:00

abstract：:A comprehensive battery of neuropsychological tests sampling a wide range of cognitive functions was administrated to 36 patients with systemic lupus erythematosus (SLE), and a control group consisting of 31 patients with persistent symptoms after whiplash injury. Our results demonstrated significant group differences...

journal_title：European journal of neurology

authors： Waterloo K,Omdal R,Mellgren SI,Husby G

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Observational study to evaluate long-term effects of deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the ventral intermediate thalamic nucleus (VIM) on patients with medically refractory myoclonus dystonia (MD). BACKGROUND:More recently, pallidal as well as thalamic DBS have been appli...

journal_title：European journal of neurology

authors： Krause P,Koch K,Gruber D,Kupsch A,Gharabaghi A,Schneider GH,Kühn AA

更新日期：2021-01-16 00:00:00

abstract：:Visual system dysfunction has been reported in Parkinson's disease (PD). The objective of the present study was to evaluate a putative association of distorted colour vision and delayed initiation and execution of movement in PD. We performed the Farnsworth-Munsell 100-hue test and estimated the total error score in 3...

journal_title：European journal of neurology

authors： Müller T,Kuhn W,Büttner T,Przuntek H

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that cause...

journal_title：European journal of neurology

authors： García-Martín E,Martínez C,Benito-León J,Calleja P,Díaz-Sánchez M,Pisa D,Alonso-Navarro H,Ayuso-Peralta L,Torrecilla D,Agúndez JA,Jiménez-Jiménez FJ

更新日期：2010-02-01 00:00:00

abstract：:In this report, we present the clinical and pathological details of a kindred of four individuals with a novel missense mutation (V272A) of the presenilin 1 gene (PSEN1) that experienced a subcortical dementia. The age of onset of symptoms ranged 26-36-year old, with an age at death of 36-46 years. Initial symptom was...

journal_title：European journal of neurology

authors： Jimenez-Escrig A,Rabano A,Guerrero C,Simon J,Barquero MS,Güell I,Ginestal RC,Montero T,Orensanz L

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite recent advances in neurogenetics that have facilitated the identification of a number of dystonia genes, many familial dystonia syndromes remain without known cause. The aim of the study was to identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affe...

journal_title：European journal of neurology

authors： Balint B,Guerreiro R,Carmona S,Dehghani N,Latorre A,Cordivari C,Bhatia KP,Bras J

更新日期：2020-08-01 00:00:00

abstract：:We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). In this family, the age at onset was young (28.0 ± 3.8 years old, mean ± SD, n = 4) a...

journal_title：European journal of neurology

authors： Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

更新日期：1995-09-01 00:00:00

abstract：:The problem of finding correspondence between a particular neuronal organization and a specific function of the human brain remains a central question of neuroscience. It is sometimes thought that language and music are two sides of the same intellectual coin, but research on brain-damaged patients has shown that the ...

journal_title：European journal of neurology

authors： Amaducci L,Grassi E,Boller F

更新日期：2002-01-01 00:00:00

abstract：:Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non-demented PD patients with V...

journal_title：European journal of neurology

authors： Ramírez-Ruiz B,Martí MJ,Tolosa E,Giménez M,Bargalló N,Valldeoriola F,Junqué C

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The detection rate of diffusion-weighted (DWI) hyperintense lesions varies widely in patients with transient global amnesia (TGA). The aim was to examine the association of hyperintense lesions on DWI magnetic resonance imaging (MRI) with patient characteristics, precipitating factors, clinical p...

journal_title：European journal of neurology

authors： Higashida K,Okazaki S,Todo K,Sasaki T,Ohara N,Kohara N,Yamamoto S,Yamagami H,Hashikawa K,Yoshimoto T,Ihara M,Koga M,Szabo K,Mochizuki H

更新日期：2020-11-01 00:00:00