Abstract:
BACKGROUND AND PURPOSE:The involvement of metabolic factors in the development of dementia has received much attention. However, previous studies have yielded conflicting results regarding how blood adipocytokine level impacts cognitive decline and dementia. This study aimed to clarify whether serum high-molecular-weight (HMW) adiponectin level is related to incident dementia. METHODS:Data were from 466 patients (mean age 67.8 years, male 57%)--who had normal cognitive function and received brain magnetic resonance imaging--from amongst the 1106 patients in the Osaka Follow-up Study for Carotid Atherosclerosis, Part 2, a prospective cohort study of cardiovascular events and dementia amongst patients with vascular risk factors enrolled between 2001 and 2009. Baseline HMW adiponectin levels were measured using frozen serum. Dementia occurrence was examined in June 2013. RESULTS:Serum HMW adiponectin level was 4.33 ± 2.95 μg/ml; the levels were lower in men than in women and negatively correlated with body mass index. During the follow-up period (median 6.9 years), 47 patients had incident dementia including Alzheimer's disease dementia (27), vascular dementia (13), mixed dementia (four), other dementia (three). Risks of dementia in patients with high versus low HMW adiponectin levels were almost identical (P = 0.689). No association was found between adiponectin levels and Alzheimer's disease dementia or vascular dementia in the whole group or amongst men and women separately. CONCLUSIONS:This study demonstrated that serum HMW adiponectin level has little association with future dementia. Determination of metabolic factors involved in dementia requires evaluation of other biomarkers or parameters.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Kitagawa K,Miwa K,Okazaki S,Sakaguchi M,Mochizuki Hdoi
10.1111/ene.12915subject
Has Abstractpub_date
2016-03-01 00:00:00pages
641-7issue
3eissn
1351-5101issn
1468-1331journal_volume
23pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers. METHODS:This st...
journal_title:European journal of neurology
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journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.2010.03207.x
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abstract:BACKGROUND:We investigated whether the prevalence of primary headaches was higher in patients with primary Sjøgren's syndrome (PSS) than in healthy individuals. METHODS:This retrospective cohort study included 71 patients with PSS (patients) based on the American European Consensus Classification criteria, and 71 age-...
journal_title:European journal of neurology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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doi:10.1111/ene.13256
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pub_type: 杂志文章,实务指引
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pub_type: 杂志文章
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journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.2006.01359.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12539
更新日期:2015-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03610.x
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abstract:BACKGROUND AND PURPOSE:Apathy is a frequent disturbance in stroke patients. The aim of this case-control study was to elucidate whether apathy: (i) was secondary to stroke or related to hospitalization, (ii) was related to thalamic and striatocapsular stroke lesions, (iii) was independent from cognitive impairment and ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03508.x
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1994-11-01 00:00:00
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journal_title:European journal of neurology
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pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
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abstract:BACKGROUND:Pre-treatment with antiplatelet agents (AP) is present amongst 30% of acute stroke patients. Previous studies have shown conflicting results on the effect of these drugs regarding haemorrhagic transformation after thrombolytic therapy. The hypothesis that pre-treatment with AP may increase the risk of cerebr...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02843.x
更新日期:2010-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00