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Association study of functional polymorphisms in serotonin transporter gene with temporal lobe epilepsy in Han Chinese population.

Abstract：

BACKGROUND AND PURPOSE:Serotoninergic dysfunction was reported to be involved in aetiology of temporal lobe epilepsy (TLE). Serotonin (5-HT) is actively cleared from synaptic cleft by serotonin transporter (5-HTT). We investigated the association between three common polymorphisms of 5-HTT gene, which may influence gene expression or function, and risk for TLE. METHODS:Three hundred and thirty-four patients with TLE and four hundred and eighty-seven non-epileptic control subjects from Han Chinese origin were enrolled for the present study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping. RESULTS:10-repeat allele frequency of 17 bp variable number of tandem repeats in the second intron (5-HTTVNTR) was moderately higher in patients with TLE than in controls (9.1% vs. 6.1%, P=0.0187, OR=1.55, 95%CI=1.07-2.26). CONCLUSION:Our study suggested 10-repeat allele of 5-HTTVNTR may be associated with TLE susceptibility.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Li J,Lin H,Zhu X,Li L,Wang X,Sun W,Wu X,Liu A,Niu F,Wang Y,Liu Y

doi

10.1111/j.1468-1331.2011.03521.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

351-3

issue

2

eissn

1351-5101

issn

1468-1331

journal_volume

19

pub_type

杂志文章

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