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Primary progressive multiple sclerosis: clinical and paraclinical characteristics with application of the new diagnostic criteria.

Abstract：

:The aim of our study was to analyse clinical and paraclinical characteristics of patients with multiple sclerosis (MS) with previous diagnosis of primary-progressive (PP) MS according to the Poser's criteria and further investigate if they fulfil the McDonald's diagnostic criteria for this disorder. A total of 561 MS patients were registered in the database at the Institute of Neurology, Belgrade, from 1 January 1997 to 31 December 2000 and 63 of them (11.2%) with previous diagnosis of PPMS were analysed retrospectively. Male/female ratio was 1.3:1 and mean age at onset 33.2 years. Most frequent at onset were pyramidal (in 73% of patients) and sensory symptoms (in 41% of patients); 74.6% of patients had greater than or equal to nine brain magnetic resonance imaging (MRI) lesions. Intrathecal oligoclonal immunoglobulin G (IgG) was detected in 96.7% and prolonged visual evoked potentials (VEP) P100 latency in 82.4% of patients. Of the total study group of 561 patients, 10.2% fulfilled the recently recommended McDonald's diagnostic criteria for the diagnosis of PPMS. Our findings further support the significance of the brain/spinal cord MRI, cerebrospinal fluid and VEP findings for precise diagnostic assessment in patients with suspected PP form of MS.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Dujmović I,Mesaros S,Pekmezović T,Lević Z,Drulović J

doi

10.1111/j.1468-1331.2004.00797.x

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

439-44

issue

7

eissn

1351-5101

issn

1468-1331

pii

ENE797

journal_volume

11

pub_type

杂志文章

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