Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease.

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to analyse the long-term impact of Guillain-Barré syndrome (GBS) on quality of life, and the relationship between clinical variables at disease onset and symptoms at follow-up to general health status. METHODS:Forty-two GBS patients were examined at median 6 years a...

journal_title：European journal of neurology

authors： Rudolph T,Larsen JP,Farbu E

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Randomized trials and meta-analyses indicate positive effects of stroke unit (SU) care on survival and dependency of patients with stroke. However, data on the advantages of SU in 'real-world' settings are limited. We prospectively assessed, in a large University Hospital, the effect of SU versus other conve...

journal_title：European journal of neurology

authors： Di Carlo A,Lamassa M,Wellwood I,Bovis F,Baldereschi M,Nencini P,Poggesi A,Cramaro A,Pescini F,Lucente G,Wolfe CD,Inzitari D,European Registers of Stroke (EROS) Project.

更新日期：2011-05-01 00:00:00

abstract：:Post-marketing surveillance studies are needed to assess the long-term safety, compliance and clinical efficacy of interferon beta-1a (IFNbeta-1a) therapy in multiple sclerosis (MS) patients. The goals of this study were to (i) assess the safety, compliance and clinical efficacy of long-term intramuscular (i.m.) IFNbe...

journal_title：European journal of neurology

authors： Coppola G,Lanzillo R,Florio C,Orefice G,Vivo P,Ascione S,Schiavone V,Pagano A,Vacca G,De Michele G,Morra VB

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenos...

journal_title：European journal of neurology

authors： Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

更新日期：2011-05-01 00:00:00

abstract：:Frontotemporal dementia (FTD) often presents with behavioural changes warranting treatment with antipsychotic medications. It is known that patients with Lewy body dementia are sensitive to developing extrapyramidal symptoms (EPS) from these medications. This has not been emphasized in FTD. We report three patients wi...

journal_title：European journal of neurology

authors： Czarnecki K,Kumar N,Josephs KA

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques. METHODS:Th...

journal_title：European journal of neurology

authors： Lecler A,Broquet V,Bailleux J,Carsin B,Adle-Biassette H,Baloglu S,Forestier G,Bonneville F,Calvier E,Chauvet D,Comby PO,Cottier JP,Cotton F,Deschamps R,Diard-Detoeuf C,Ducray F,Drissi C,Elmaleh M,Farras J,Aguilar Ga

更新日期：2020-08-01 00:00:00

abstract：:While optimal treatment strategies are widely established for daytime treatment of Parkinson's disease (PD), nighttime problems of PD are often not adequately addressed in clinical practice. Nocturnal/sleep disturbance is common in PD and occurs due to a combination of the disease process and effect of dopaminergic an...

journal_title：European journal of neurology

authors： Chaudhuri KR

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Humanized monoclonal antibody galcanezumab, which binds to calcitonin-gene-related peptide, has shown efficacy for episodic and chronic migraine prevention. These analyses evaluated galcanezumab response for migraine headache prevention in patients who previously failed onabotulinumtoxinA ('nonre...

journal_title：European journal of neurology

authors： Ailani J,Pearlman E,Zhang Q,Nagy AJ,Schuh K,Aurora SK

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study investigated whether incompleteness of the anterior part of the circle of Willis affects the occurrence of lacunes in the basal ganglia. METHODS:One thousand and seventy-seven healthy individuals examined by magnetic resonance (MR) imaging and MR angiography were divided into eight su...

journal_title：European journal of neurology

authors： Miyazawa N,Shinohara T,Yamagata Z

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The National Institute for Health and Care Excellence (NICE) in the UK recommends the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service. In view of the lack of data on the efficacy of this therapy...

journal_title：European journal of neurology

authors： Andreou AP,Trimboli M,Al-Kaisy A,Murphy M,Palmisani S,Fenech C,Smith T,Lambru G

更新日期：2018-08-01 00:00:00

abstract：:Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries. No studies were identified from large areas of Europe, especially from the former eastern Europe (except the Baltic countries) and the eastern Mediterranean countries. Based...

journal_title：European journal of neurology

authors： Forsgren L,Beghi E,Oun A,Sillanpää M

更新日期：2005-04-01 00:00:00

abstract：:The diagnosis of mitochondrial encephalomyopathies is complex and a system for classification of the diagnosis as definite, probable, and possible has been proposed. The objective of this study was to explore the spectrum of epileptic disorders associated with probable and definite mitochondrial disease in children us...

journal_title：European journal of neurology

authors： Sadleir LG,Connolly MB,Applegarth D,Hendson G,Clarke L,Rakshi C,Farrell K

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Behçet's disease (BD) is a multisystemic, recurrent, inflammatory disorder. Neurological involvement is well-known but cerebral vasculitis and ischaemic stroke are unusual. CASE DESCRIPTION:A 43-year-old male patient presented with acute left hemiparesis, he had recurrent oral aphthae and scrotal ulcerati...

journal_title：European journal of neurology

authors： Krespi Y,Akman-Demir G,Poyraz M,Tugcu B,Coban O,Tuncay R,Serdaroglu P,Bahar S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Body mass index (BMI), hyperglycaemia and type 2 diabetes and their interactive effects are associated with brain volume atrophy in ageing. It remains to be established if these risk factors are particularly concerning in individuals with high or low brain volumes. METHODS:Demographics, venous b...

journal_title：European journal of neurology

authors： Walsh EI,Shaw M,Sachdev P,Anstey KJ,Cherbuin N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) disease is a chronic, slowly progressing disorder. The lack of specific disease progression biomarkers limits the execution of clinical trials. However, neurofilament light chain (NfL) has been suggested as a potential biomarker for peripheral nervous system disorders. ...

journal_title：European journal of neurology

authors： Millere E,Rots D,Simrén J,Ashton NJ,Kupats E,Micule I,Priedite V,Kurjane N,Blennow K,Gailite L,Zetterberg H,Kenina V

更新日期：2020-12-19 00:00:00

abstract：BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS)-related genes and mutations have been increasingly discovered recently and an improved understanding of genotype-phenotype relationships may help to predict the disease course and refine genetic diagnosis. METHODS:We collected clinical data and blood samples f...

journal_title：European journal of neurology

authors： Chen W,Xie Y,Zheng M,Lin J,Huang P,Pei Z,Yao X

更新日期：2020-06-01 00:00:00

abstract：:We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). In this family, the age at onset was young (28.0 ± 3.8 years old, mean ± SD, n = 4) a...

journal_title：European journal of neurology

authors： Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We investigated the effectiveness of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS) patients with large vessel or distal occlusions and mild neurological deficits, defined as National Institutes of Health Stroke Scale scores < 6 points. METHODS:The primary efficacy outcome was 3-...

journal_title：European journal of neurology

authors： Tsivgoulis G,Goyal N,Katsanos AH,Malhotra K,Ishfaq MF,Pandhi A,Frohler MT,Spiotta AM,Anadani M,Psychogios M,Maus V,Siddiqui A,Waqas M,Schellinger PD,Groen M,Krogias C,Richter D,Saqqur M,Garcia-Bermejo P,Mokin M,Le

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the association between having non-thymoma myasthenia and the risk of extra-thymic cancer in a population-based setting. METHODS:A nationwide case-control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer du...

journal_title：European journal of neurology

authors： Pedersen EG,Pottegård A,Hallas J,Friis S,Hansen K,Jensen PE,Gaist D

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) 1C due to mutations in LITAF/SIMPLE is a rare subtype amongst the autosomal dominant demyelinating forms of CMT. Our objective was to report the clinical and electrophysiological characteristics of 18 CMT1C patients and compare them to 20 patients with PMP22 mutations: 1...

journal_title：European journal of neurology

authors： Guimarães-Costa R,Iancu Ferfoglia R,Leonard-Louis S,Ziegler F,Magy L,Fournier E,Dubourg O,Bouche P,Maisonobe T,Lacour A,Moerman A,Latour P,Stojkovic T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The association between past stroke subtypes and recurrent stroke subtypes in non-cardiogenic stroke remains unknown. METHODS:Patients with ischaemic stroke who had a past history of large-artery disease (LAD) or small-artery disease (SAD) subtypes were assessed. LAD was subdivided into intracra...

journal_title：European journal of neurology

authors： Yoon Y,Lee DH,Kang DW,Kwon SU,Suh DC,Bang OY,Kim JS

更新日期：2013-06-01 00:00:00

abstract：:We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in acti...

journal_title：European journal of neurology

authors： Starkstein SE,Migliorelli R,Manes F,Tesón A,Petracca G,Chemerinski E,Sabe L,Leiguarda R

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To examine the relative risk (RR) for living in nursing homes for patients with Parkinson's disease (PD) compared with the general population and to ascertain society's costs related to nursing home placement for this patient group. METHODS:We evaluated the frequency of admission to nursing home...

journal_title：European journal of neurology

authors： Vossius C,Nilsen OB,Larsen JP

更新日期：2009-02-01 00:00:00

abstract：:Mirror movements (MM), involuntary movements of homologous muscles opposite to unilateral limb activity, decrease in the course of motor development, but may reappear in adults after brain damage. To better characterize this type of acquired MM, grip forces of 36 healthy subjects and 35 patients suffering from focal b...

journal_title：European journal of neurology

authors： Uttner I,Mai N,Esslinger O,Danek A

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Multiple mitochondrial DNA (mtDNA) deletions usually have a mendelian inheritance secondary to mutation in nuclear genes. One of these is the Twinkle gene whose mutation is responsible for autosomal dominant progressive external ophthalmoplegia (PEO). The number of reported cases with mainly myopathic sympto...

journal_title：European journal of neurology

authors： Martin-Negrier ML,Sole G,Jardel C,Vital C,Ferrer X,Vital A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The severity of Wilson's disease (WD) is linked to free copper accumulating in the liver and brain. Exchangeable copper (CuEXC) is a new technique to determine plasmatic copper and is useful in the diagnosis of WD. It is hypothesized that it may also enable a good evaluation of extra-hepatic invo...

journal_title：European journal of neurology

authors： Poujois A,Trocello JM,Djebrani-Oussedik N,Poupon J,Collet C,Girardot-Tinant N,Sobesky R,Habès D,Debray D,Vanlemmens C,Fluchère F,Ory-Magne F,Labreuche J,Preda C,Woimant F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of our study was to describe patients with the p.D12Y variant (previously reported as D11Y) in SOD1 showing heterogeneous clinicopathological features. METHODS:We performed clinical, electrophysiological, magnetic resonance imaging (MRI) and muscle pathology studies in four SOD1 p.D12Y v...

journal_title：European journal of neurology

authors： Tasca G,Lattante S,Marangi G,Conte A,Bernardo D,Bisogni G,Mandich P,Zollino M,Ragozzino E,Udd B,Sabatelli M

更新日期：2020-07-01 00:00:00

abstract：:Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial...

journal_title：European journal of neurology

authors： Stefan H,Steinhoff BJ

更新日期：2007-10-01 00:00:00

abstract：:We report here 39 cases in which definite multiple sclerosis (MS) was precipitated or exacerbated by specific hyperextension-hyperflexion cervical cord trauma. The worsening or onset of the symptomatic disease bore a striking temporal relationship to the focal injury. Our data suggests that central nervous system (CNS...

journal_title：European journal of neurology

authors： Chaudhuri A,Behan PO

更新日期：2001-11-01 00:00:00

abstract：:We examined clinical presentations, neuropsychological findings, and perfusion patterns of (99m)Tc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients with early stage dementia with Lewy bodies (DLB) (n = 17) and Parkinson's disease (PD) (n = 16), with age-matched healthy contro...

journal_title：European journal of neurology

authors： Chang CC,Liu JS,Chang YY,Chang WN,Chen SS,Lee CH

更新日期：2008-01-01 00:00:00