Acute cervical hyperextension-hyperflexion injury may precipitate and/or exacerbate symptomatic multiple sclerosis.

Abstract:

:We report here 39 cases in which definite multiple sclerosis (MS) was precipitated or exacerbated by specific hyperextension-hyperflexion cervical cord trauma. The worsening or onset of the symptomatic disease bore a striking temporal relationship to the focal injury. Our data suggests that central nervous system (CNS)-specific acute physical trauma such as cervical cord hyperextension-hyperflexion injury may aggravate latent clinical symptoms in MS. The deterioration of MS bore no direct relationship with the severity of neck injury. Possible pathogenic mechanisms of focal CNS-specific trauma aggravating the course of asymptomatic or benign MS are discussed. This may have implications in improving our understanding of the factors that may modify the clinical course of MS.

journal_name

Eur J Neurol

authors

Chaudhuri A,Behan PO

doi

10.1046/j.1468-1331.2001.00292.x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

659-64

issue

6

eissn

1351-5101

issn

1468-1331

pii

292

journal_volume

8

pub_type

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