A combination of total tau and neurofilaments discriminates between neurodegenerative and primary psychiatric disorders.

abstract：:Upper limb spasticity affecting elbow, wrist, and finger flexors can be safely and effectively reduced with injections of botulinum toxin type-A (BoNT-A). It has been best studied in adults in the context of post-stroke spasticity. The clinical benefits include reduction in pain and deformity, improvement in washing a...

journal_title：European journal of neurology

authors： Sheean G,Lannin NA,Turner-Stokes L,Rawicki B,Snow BJ,Cerebral Palsy Institute.

更新日期：2010-08-01 00:00:00

abstract：:We report on a patient who presented with isolated transient headache as the only manifestation of pituitary apoplexy. A high index of suspicion and MRI led to the diagnosis. Copyright 1998 Lippincott Williams & Wilkins ...

journal_title：European journal of neurology

authors： Hernandez A,Angeles Del Real M,Aguirre M,Vaamonde J,Gudin M,Ibanez R

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose was to evaluate the association between the left ventricular ejection fraction (LVEF) and cerebral small vessel disease (cSVD) in ischaemic stroke patients. METHODS:Consecutive first-ever ischaemic stroke patients between 2010 and 2013 were included. White matter hyperintensity (WMH)...

journal_title：European journal of neurology

authors： Nam KW,Kwon HM,Kim HL,Lee YS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our objective was to study the association between serum levels of anti Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody and 25-hydroxyvitamin D (25(OH)D) in a prospective cohort of patients with relapsing-remitting multiple sclerosis. METHOD:The study comprised 90 patients with relapsing-...

journal_title：European journal of neurology

authors： Wergeland S,Myhr KM,Løken-Amsrud KI,Beiske AG,Bjerve KS,Hovdal H,Midgard R,Kvistad SS,Holmøy T,Riise T,Torkildsen Ø

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The HLA-DRB1*15 allele is consistently associated with multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the association between HLA-DRB1 alleles and the presence of oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid (CSF) in a Spanish ...

journal_title：European journal of neurology

authors： Romero-Pinel L,Martínez-Yélamos S,Bau L,Matas E,Gubieras L,María Pujal J,Morandeira F,Bas J,Arbizu T

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although Labrune syndrome is a well-known disorder characterized by a typical neuroradiological triad, namely leukoencephalopathy, intracranial calcifications and cysts, there are no reports of systemic involvement in this disorder. This paper attempts to describe a peculiar clinical manifestatio...

journal_title：European journal of neurology

authors： Bonomo G,Monfrini E,Borellini L,Bonomo R,Arienti F,Saetti MC,Di Fonzo A,Locatelli M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Haemorrhagic transformation (HT) is common after acute ischaemic stroke. Whether liver function plays a role in HT remains an open question. METHODS:Acute ischaemic stroke patients within 7 days from stroke onset were included. Baseline data including liver function tests were collected. An inde...

journal_title：European journal of neurology

authors： Tan G,Lei C,Hao Z,Chen Y,Yuan R,Liu M

更新日期：2016-03-01 00:00:00

abstract：:In this report, we present the clinical and pathological details of a kindred of four individuals with a novel missense mutation (V272A) of the presenilin 1 gene (PSEN1) that experienced a subcortical dementia. The age of onset of symptoms ranged 26-36-year old, with an age at death of 36-46 years. Initial symptom was...

journal_title：European journal of neurology

authors： Jimenez-Escrig A,Rabano A,Guerrero C,Simon J,Barquero MS,Güell I,Ginestal RC,Montero T,Orensanz L

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Prevalence rates of headache in multiple sclerosis (MS) patients varied widely in recent studies. This study aimed to investigate the 1 year prevalence of headache in MS compared with the general population. METHODS:Population-based case-control study in Germany. RESULTS:We included 491 patients with defin...

journal_title：European journal of neurology

authors： Putzki N,Pfriem A,Limmroth V,Yaldizli O,Tettenborn B,Diener HC,Katsarava Z

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The ataxias are a challenging group of neurological diseases due the aetiological heterogeneity and the complexity of the genetic subtypes. This guideline focuses on the heredodegenerative ataxias. The aim is to provide a peer-reviewed evidence-based guideline for clinical neurologists and oth...

journal_title：European journal of neurology

authors： van de Warrenburg BP,van Gaalen J,Boesch S,Burgunder JM,Dürr A,Giunti P,Klockgether T,Mariotti C,Pandolfo M,Riess O

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is an urgent need for early predictive markers for the course of disease in prodromal α-synucleinopathies such as idiopathic rapid eye movement (REM) sleep behaviour disorder. Autonomic cardiac/vascular dysfunction is a prominent feature in advanced α-synucleinopathies, but its diagnostic v...

journal_title：European journal of neurology

authors： Dahms C,Guenther A,Schwab M,Schultze T,Nowack S,Hoyer D,Ehrhardt J,Witte OW,Mayer G,Rupprecht S

更新日期：2016-05-01 00:00:00

abstract：:We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). In this family, the age at onset was young (28.0 ± 3.8 years old, mean ± SD, n = 4) a...

journal_title：European journal of neurology

authors： Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...

journal_title：European journal of neurology

authors： Bianchi M,Cosseddu M,Cotelli M,Manenti R,Brambilla M,Rizzetti MC,Padovani A,Borroni B

更新日期：2015-09-01 00:00:00

abstract：:We report here 39 cases in which definite multiple sclerosis (MS) was precipitated or exacerbated by specific hyperextension-hyperflexion cervical cord trauma. The worsening or onset of the symptomatic disease bore a striking temporal relationship to the focal injury. Our data suggests that central nervous system (CNS...

journal_title：European journal of neurology

authors： Chaudhuri A,Behan PO

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although cerebrovascular disorders are the main cause of epilepsia partialis continua (EPC) in adulthood, the frequency of EPC after stroke is unknown. The aim was to prospectively ascertain its frequency 1 year after an ischaemic stroke. METHODS:This was a prospective study of consecutive acute...

journal_title：European journal of neurology

authors： Bentes C,Franco AC,Peralta AR,Viana P,Martins H,Morgado C,Casimiro C,Fonseca C,Geraldes R,Canhão P,Pinho E Melo T,Paiva T,Ferro JM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking. METHODS:Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by th...

journal_title：European journal of neurology

authors： Granic A,Hill TR,Kirkwood TB,Davies K,Collerton J,Martin-Ruiz C,von Zglinicki T,Saxby BK,Wesnes KA,Collerton D,Mathers JC,Jagger C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Depressed mood is a common psychiatric problem associated with Parkinson's disease (PD), and studies have suggested a benefit of rasagiline treatment. METHODS:ACCORDO (see the ) was a 12-week, double-blind, placebo-controlled trial to evaluate the effects of rasagiline 1 mg/day on depressive sym...

journal_title：European journal of neurology

authors： Barone P,Santangelo G,Morgante L,Onofrj M,Meco G,Abbruzzese G,Bonuccelli U,Cossu G,Pezzoli G,Stanzione P,Lopiano L,Antonini A,Tinazzi M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Conversion disorder (CD), or functional neurological disorder, is manifested as a neurological disturbance that is not macroscopically visible on clinical structural neuroimaging and is instead ascribed to underlying psychological stress. Known for many years in neuropsychiatry, a comprehensive e...

journal_title：European journal of neurology

authors： Monsa R,Peer M,Arzy S

更新日期：2018-06-01 00:00:00

abstract：:The Australian Pregnancy Registry, affiliated European Register of Antiepileptic drugs in Pregnancy (EURAP), recruits informed consenting women with epilepsy on treatment with antiepileptic drugs (AEDs), those untreated, and women on AEDs for other indications. Enrolment is considered prospective if it has occurred be...

journal_title：European journal of neurology

authors： Vajda FJ,Hitchcock A,Graham J,Solinas C,O'Brien TJ,Lander CM,Eadie MJ

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition. METHODS:A detailed analysis of the cognitive course of the two forms is presented, span...

journal_title：European journal of neurology

authors： Frisch C,Malter MP,Elger CE,Helmstaedter C

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Screening batteries to narrow down a target-at-risk population are essential for trials testing neuroprotective compounds aiming to delay or prevent onset of Parkinson's disease (PD). METHODS:The PRIPS study focuses on early detection of incident PD in 1847 at baseline PD-free subjects, and asse...

journal_title：European journal of neurology

authors： Berg D,Godau J,Seppi K,Behnke S,Liepelt-Scarfone I,Lerche S,Stockner H,Gaenslen A,Mahlknecht P,Huber H,Srulijes K,Klenk J,Fassbender K,Maetzler W,Poewe W,PRIPS study group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Whether the neuromelanin-positive substantia nigra pars compacta area (NM-SNc) on neuromelanin magnetic resonance imaging (NM-MRI) and the specific binding ratio (SBR) on 123 I-N-v-fluoropropyl-2b-carbomethoxy3b-(4-iodophenyl)nortropane single photon emission computed tomography (DaT-SPECT) can b...

journal_title：European journal of neurology

authors： Okuzumi A,Hatano T,Kamagata K,Hori M,Mori A,Oji Y,Taniguchi D,Daida K,Shimo Y,Yanagisawa N,Nojiri S,Aoki S,Hattori N

更新日期：2019-11-01 00:00:00

abstract：:Hereditary spastic paraparesis (HSP) is a heterogeneous group of neurodegenerative disorders with progressive lower limb spasticity, categorized into pure (p-HSP) and complicated forms (c-HSP). The purpose of this study was to evaluate if brain volumes in HSP were altered compared with a control population. Brain volu...

journal_title：European journal of neurology

authors： Kassubek J,Sperfeld AD,Baumgartner A,Huppertz HJ,Riecker A,Juengling FD

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To assess the efficacy and safety of olesoxime, a molecule with neuroprotective properties, in patients with amyotrophic lateral sclerosis (ALS) treated with riluzole. METHODS:A double-blind, randomized, placebo-controlled, multicenter trial of 18 months' duration was conducted in 512 subjects, ...

journal_title：European journal of neurology

authors： Lenglet T,Lacomblez L,Abitbol JL,Ludolph A,Mora JS,Robberecht W,Shaw PJ,Pruss RM,Cuvier V,Meininger V,Mitotarget study group.

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Differentiation between parkinsonian type multiple system atrophy (MSA-P) and Parkinson's disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in diff...

journal_title：European journal of neurology

authors： Kwon KY,Choi CG,Kim JS,Lee MC,Chung SJ

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several studies have reported associations between brain iron deposits (IDs), white matter hyperintensities (WMHs) and cognitive ability in older individuals. Whether the association between brain IDs and cognitive abilities in older people is mediated by or independent of total brain tissue dama...

journal_title：European journal of neurology

authors： Valdés Hernández M,Allerhand M,Glatz A,Clayson L,Muñoz Maniega S,Gow A,Royle N,Bastin M,Starr J,Deary I,Wardlaw J

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Certain miscellaneous idiopathic headache disorders, which are regarded as entities, are grouped in Chapter 4 of the International Classification of Headache Disorders. Recent epidemiological research suggests that these headache disorders are underdiagnosed. OBJECTIVES:To give expert recommenda...

journal_title：European journal of neurology

authors： Evers S,Goadsby P,Jensen R,May A,Pascual J,Sixt G,EFNS task force.

更新日期：2011-06-01 00:00:00

abstract：:The diagnosis of mitochondrial encephalomyopathies is complex and a system for classification of the diagnosis as definite, probable, and possible has been proposed. The objective of this study was to explore the spectrum of epileptic disorders associated with probable and definite mitochondrial disease in children us...

journal_title：European journal of neurology

authors： Sadleir LG,Connolly MB,Applegarth D,Hendson G,Clarke L,Rakshi C,Farrell K

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS) is classically assumed to be a neurodegenerative disorder. Inflammation has been observed in CNS tissue in ALS patients. We investigated the expression and prognostic relevance of proinflammatory chemokines in ALS. METHODS:We analyzed nine chemokines, eotaxin,...

journal_title：European journal of neurology

authors： Kuhle J,Lindberg RL,Regeniter A,Mehling M,Steck AJ,Kappos L,Czaplinski A

更新日期：2009-06-01 00:00:00

abstract：:It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy-two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disabi...

journal_title：European journal of neurology

authors： De Reuck J,Claeys I,Martens S,Vanwalleghem P,Van Maele G,Phlypo R,Hallez H

更新日期：2006-04-01 00:00:00