Abstract:
:Selenium is an essential component of the antioxidant enzyme glutathione peroxidase. The activity of this enzyme is reduced in the substantia nigra of patients with Parkinson's disease (PD), but the results of studies on erythrocytes are controversial. We compared the serum levels of selenium and the 24 h urinary selenium excretion (measured by hydride generation atomic absorption spectrophotometry) in 29 PD patients and 30 matched controls. Serum selenium levels were significantly lower in PD patients than in controls (34.6 ± 2.35 and 45.2 ± 3.83 μg/l, p < 0.05) while urinary excretion was similar for both groups (47.1 ± 6.25 and 45.5 ± 5.38 μg/24 h). These values were not influenced by antiparkinsonian drugs, and they did not correlate with age, age at onset and duration of the PD, scores of the Unified PD Rating Scale or the Hoehn and Yahr staging in the PD group. These results might suggest a possible role of low serum selenium levels in the risk for, or a consequence of the oxidative stress in PD.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Jiménez-Jiménez FJ,Molina JA,Arrieta FJ,Aguilar MV,Cabrera-Valdivia F,Vázquez A,Jorge-Santamaría A,Seijas V,Fernández-Calle P,Martínez-Para MCdoi
10.1111/j.1468-1331.1995.tb00102.xsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
111-4issue
2eissn
1351-5101issn
1468-1331journal_volume
2pub_type
杂志文章abstract::We present the baseline characteristics of 101 patients with normal pressure hydrocephalus (NPH), entering a study that evaluates the diagnostic reliability of CSF outflow resistance. Patients were assessed by a gait scale consisting of 10 features of walking and the number of steps and seconds necessary for 10 m, a d...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1997.tb00297.x
更新日期:1997-01-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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doi:10.1046/j.1468-1331.1998.510035.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03663.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.510103.x
更新日期:1998-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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doi:10.1111/ene.12300
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01986.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.560619.x
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
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doi:10.1111/ene.13256
更新日期:2017-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1999.660639.x
更新日期:1999-11-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,meta分析
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更新日期:2012-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14313
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00481.x
更新日期:2003-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.520181.x
更新日期:1998-03-01 00:00:00