Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes.

Abstract:

:In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies, neuron-specific Hu antigens expressed by the tumour hypothetically trigger an immune response that cross-reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized cell-mediated immune pathogenesis of these syndromes, we analysed the circulating lymphocyte subsets in untreated patients with SCLC, PNS and Hu antibodies (n = 18), SCLC without PNS (n = 19) and controls (n = 29) using flow cytometry. SCLC patients with PNS had a variety of imbalances within their circulating lymphocyte subsets as compared with SCLC patients without PNS and healthy controls: (i) a lymphopenia of the major subsets (i.e. B, CD4+ and CD8+ T lymphocytes); (ii) increased proportions of activated CD4+ and CD8+ T cells; (iii) reduced numbers of terminally differentiated effector CD8+ T cells and cells with a cytotoxic T-cell phenotype (CD56+ and CD57+). Although indirect, our data provide further support for the involvement of T cells in the pathogenesis of Hu antibody associated PNS.

journal_name

Eur J Neurol

authors

de Beukelaar JW,Sillevis Smitt PA,Hop WC,Kraan J,Hooijkaas H,Verjans GM,Gratama JW

doi

10.1111/j.1468-1331.2007.01986.x

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1383-91

issue

12

eissn

1351-5101

issn

1468-1331

pii

ENE1986

journal_volume

14

pub_type

杂志文章
  • Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients.

    abstract::A comprehensive battery of neuropsychological tests sampling a wide range of cognitive functions was administrated to 36 patients with systemic lupus erythematosus (SLE), and a control group consisting of 31 patients with persistent symptoms after whiplash injury. Our results demonstrated significant group differences...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1997.tb00323.x

    authors: Waterloo K,Omdal R,Mellgren SI,Husby G

    更新日期:1997-03-01 00:00:00

  • Association of incompleteness of the anterior part of the circle of Willis with the occurrence of lacunes in the basal ganglia.

    abstract:BACKGROUND AND PURPOSE:This study investigated whether incompleteness of the anterior part of the circle of Willis affects the occurrence of lacunes in the basal ganglia. METHODS:One thousand and seventy-seven healthy individuals examined by magnetic resonance (MR) imaging and MR angiography were divided into eight su...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03400.x

    authors: Miyazawa N,Shinohara T,Yamagata Z

    更新日期:2011-11-01 00:00:00

  • Altered resting-state functional connectivity between subregions in the thalamus and cortex in migraine without aura.

    abstract:BACKGROUND AND PURPOSE:Migraine is a complex and disabling neurological disorder, the exact neurological mechanisms of which remain unclear. The thalamus is considered to be the hub of the central processing and integration of nociceptive information, as well as the modulation of these processes. METHODS:A total of 48...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14411

    authors: Qin ZX,Su JJ,He XW,Zhu Q,Cui YY,Zhang JL,Wang MX,Gao TT,Tang W,Hu Y,Liu YS,Qiao Y,Liu JR,Li JQ,Du XX

    更新日期:2020-11-01 00:00:00

  • EFNS guidelines on pharmacological treatment of neuropathic pain.

    abstract::Neuropathic pain treatment remains unsatisfactory despite a substantial increase in the number of trials. This EFNS Task Force aimed at evaluating the existing evidence about the pharmacological treatment of neuropathic pain. Studies were identified using first the Cochrane Database then Medline. Trials were classifie...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1468-1331.2006.01511.x

    authors: Attal N,Cruccu G,Haanpää M,Hansson P,Jensen TS,Nurmikko T,Sampaio C,Sindrup S,Wiffen P,EFNS Task Force.

    更新日期:2006-11-01 00:00:00

  • The societal cost of Huntington's disease: are we underestimating the burden?

    abstract:BACKGROUND AND PURPOSE:Approximately 9000 people in the UK are affected by Huntington's disease (HD). People with HD require ongoing health and social care support. There is a knowledge gap about costs of health and social care use associated with HD in the UK. This paper estimates the economic cost in the UK. METHODS...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13107

    authors: Jones C,Busse M,Quinn L,Dawes H,Drew C,Kelson M,Hood K,Rosser A,Edwards RT

    更新日期:2016-10-01 00:00:00

  • An exploration of anger phenomenology in multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Multiple sclerosis (MS) patients are often emotionally disturbed. We investigated anger in these patients in relation to demographic, clinical, and mood characteristics. PATIENTS AND METHODS:About 195 cognitively unimpaired MS patients (150 relapsing-remitting and 45 progressive) were evaluated ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02727.x

    authors: Nocentini U,Tedeschi G,Migliaccio R,Dinacci D,Lavorgna L,Bonavita S,Bresciamorra V,Comanducci G,Coniglio G,Livrea P,Mannu R,Orefice G,Paciello M,Patti F,Quattrone A,Salemi G,Savettieri G,Simone IL,Valentino P,Zappia

    更新日期:2009-12-01 00:00:00

  • Atrophy of optic nerve detected by transorbital sonography in patients with demyelinating diseases of the central nervous system.

    abstract:BACKGROUND AND PURPOSE:Transorbital sonography (TOS) has emerged as promising imaging method for the diagnosis and follow-up of acute optic neuritis (ON). Available studies report an increase in the optic nerve diameter (OND) and the optic nerve sheath diameter (ONSD) in the case of a first episode of ON in the affecte...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14137

    authors: Schroeder C,Katsanos AH,Ayzenberg I,Schwake C,Gahlen A,Tsivgoulis G,Voumvourakis K,Gold R,Krogias C

    更新日期:2020-04-01 00:00:00

  • A descriptive study on constructional impairment in frontotemporal dementia and Alzheimer's disease.

    abstract:BACKGROUND AND PURPOSE:Frontotemporal dementia (FTD) is a degenerative disorder characterized, in its frontal variant, by psychiatric onset, deficits in executive functions and sparing of memory and visuo-spatial abilities. Studies on visuo-spatial abilities in FTD and Alzheimer's disease (AD) have mainly focused on co...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02128.x

    authors: Gasparini M,Masciarelli G,Vanacore N,Ottaviani D,Salati E,Talarico G,Lenzi GL,Bruno G

    更新日期:2008-06-01 00:00:00

  • Impact of seizures on morbidity and mortality after stroke: a Canadian multi-centre cohort study.

    abstract:INTRODUCTION:Limited information is available about the impact of seizures on stroke outcome, health care delivery and resource utilization. OBJECTIVE:To determine whether the presence of seizures after stroke increases disability, mortality and health care utilization (length of hospital stay, ICU admission, consults...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1468-1331.2009.02739.x

    authors: Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

    更新日期:2010-01-01 00:00:00

  • Insulin-like growth factor-1 predicts cognitive functions at 2-year follow-up in early, drug-naïve Parkinson's disease.

    abstract:BACKGROUND AND PURPOSE:Cognitive impairment is common in Parkinson's disease (PD), even in the early stages. We aimed to assess the relationship between insulin-like growth factor-1 (IGF-1) and cognitive functions in early, drug-naïve patients with PD. METHODS:Serum IGF-1 was measured in 65 early, drug-naïve patients ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12137

    authors: Pellecchia MT,Santangelo G,Picillo M,Pivonello R,Longo K,Pivonello C,Vitale C,Amboni M,De Rosa A,Moccia M,Erro R,De Michele G,Santoro L,Colao A,Barone P

    更新日期:2014-05-01 00:00:00

  • EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.

    abstract:BACKGROUND:Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life. OBJECTIVES:To create practical guidelines for diagnosis, management and prevention of the disease. METHODS:We searched MEDLINE, EMBASE, LILACS, Cochrane Library. CONCLUSIONS AND REC...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1468-1331.2010.03153.x

    authors: Galvin R,Bråthen G,Ivashynka A,Hillbom M,Tanasescu R,Leone MA,EFNS.

    更新日期:2010-12-01 00:00:00

  • (CAG)n loci as genetic modifiers of age at onset in patients with spinocerebellar ataxia type 1 from mainland China.

    abstract:BACKGROUND AND PURPOSE:The expanded repeat length in ATXN1 negatively correlates with age at onset (AAO) of spinocerebellar ataxia type 1 (SCA1) but can explain only part of it, indicating that other factors affect AAO. Some studies have explored the influence of non-causative CAG repeats on the AAO of SCA patients. Ho...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13954

    authors: Wang P,Chen Z,Peng Y,Cao L,Li X,Wang C,Yang H,Peng H,Shi Y,Zhou X,Li T,Feng L,Wu C,Qiu R,Xia K,Tang B,Jiang H

    更新日期:2019-08-01 00:00:00

  • Total drug treatment and comorbidity in myasthenia gravis: a population-based cohort study.

    abstract:BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12439

    authors: Andersen JB,Owe JF,Engeland A,Gilhus NE

    更新日期:2014-07-01 00:00:00

  • Apathy in acute stroke patients.

    abstract:BACKGROUND AND PURPOSE:Apathy is a frequent disturbance in stroke patients. The aim of this case-control study was to elucidate whether apathy: (i) was secondary to stroke or related to hospitalization, (ii) was related to thalamic and striatocapsular stroke lesions, (iii) was independent from cognitive impairment and ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03508.x

    authors: Caeiro L,Ferro JM,Figueira ML

    更新日期:2012-02-01 00:00:00

  • Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.

    abstract:BACKGROUND AND PURPOSE:  Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. METHODS:  We conducted a population-based cohort study using the General Practice Research D...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2012.03668.x

    authors: Lalmohamed A,Bazelier MT,Van Staa TP,Uitdehaag BM,Leufkens HG,De Boer A,De Vries F

    更新日期:2012-07-01 00:00:00

  • Prevalence of overweight, obesity and metabolic syndrome components in multiple sclerosis patients with significant disability.

    abstract:BACKGROUND AND PURPOSE:Information about metabolic comorbidities in patients with multiple sclerosis (MS) is scarce. Our aim was to examine the prevalence of the metabolic syndrome (MetS) and its components in patients with long duration of MS and significant disability. METHODS:Demographic and clinical data, weight, ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12738

    authors: Pinhas-Hamiel O,Livne M,Harari G,Achiron A

    更新日期:2015-09-01 00:00:00

  • Exploding Head Syndrome (a.k.a. Episodic Cranial Sensory Shock) responds to single-pulse TMS.

    abstract::We here present the case of a patient with a sleep disturbance attributed to the exploding head syndrome, recently redefined as 'episodic cranial sensory shock'. The patient, who suffered with concomitant migraine, was treated for headache prevention with daily single-pulse transcranial magnetic stimulation. Following...

    journal_title:European journal of neurology

    pub_type:

    doi:10.1111/ene.14747

    authors: Puledda F,Moreno-Ajona D,Goadsby PJ

    更新日期:2021-01-18 00:00:00

  • Prevalence of renal dysfunction in ischaemic stroke and transient ischaemic attack patients with or without atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12528

    authors: Laible M,Horstmann S,Rizos T,Rauch G,Zorn M,Veltkamp R

    更新日期:2015-01-01 00:00:00

  • Variables linked to psychotic symptoms in Alzheimer's disease.

    abstract::This study is aimed at assessing the prevalence and features of psychotic symptoms in a sample of 180 patients with Alzheimer's disease (AD). Sixty-four patients (35.5% of the sample) showed one or more psychotic symptoms. The presence of these symptoms correlated with the severity of the patients' cognitive impairmen...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1998.560553.x

    authors: Sala SD,Francescani A,Muggia S,Spinnler H

    更新日期:1998-11-01 00:00:00

  • Phenotypic spectrum of Charcot-Marie-Tooth disease due to LITAF/SIMPLE mutations: a study of 18 patients.

    abstract:BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) 1C due to mutations in LITAF/SIMPLE is a rare subtype amongst the autosomal dominant demyelinating forms of CMT. Our objective was to report the clinical and electrophysiological characteristics of 18 CMT1C patients and compare them to 20 patients with PMP22 mutations: 1...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13239

    authors: Guimarães-Costa R,Iancu Ferfoglia R,Leonard-Louis S,Ziegler F,Magy L,Fournier E,Dubourg O,Bouche P,Maisonobe T,Lacour A,Moerman A,Latour P,Stojkovic T

    更新日期:2017-03-01 00:00:00

  • The effects of interferon-beta on interleukin-10 in multiple sclerosis patients.

    abstract::The incidence of the neuropathological lesions and the severity of the clinical symptoms in multiple sclerosis (MS) are correlated with the amount of the transferred autoreactive T cells. The balance between the T helper 1 (Th1) and T helper 2 (Th2) cytokine phenotypes may affect the activity of the disease in MS pati...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1468-1331.2004.00986.x

    authors: Ersoy E,Kuş CN,Sener U,Coker I,Zorlu Y

    更新日期:2005-03-01 00:00:00

  • The assessment of depression in Parkinson's disease.

    abstract:BACKGROUND:Motor symptoms form the hallmark of Parkinson's Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery-Asberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of t...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02101.x

    authors: Koerts J,Leenders KL,Koning M,Bouma A,van Beilen M

    更新日期:2008-05-01 00:00:00

  • Impact of cardiovascular risk factors on cognitive function: the Tromsø study.

    abstract:BACKGROUND AND PURPOSE:The role of cardiovascular risk factors in the pathogenesis of cognitive impairment and dementia remains still unclear. We examined the impact of cardiovascular risk factors on cognitive function in a large longitudinal population study. METHODS:Subjects were 5033 stroke-free men and women who p...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03263.x

    authors: Arntzen KA,Schirmer H,Wilsgaard T,Mathiesen EB

    更新日期:2011-05-01 00:00:00

  • Dutch normal pressure hydrocephalus study: baseline characteristics with emphasis on clinical findings.

    abstract::We present the baseline characteristics of 101 patients with normal pressure hydrocephalus (NPH), entering a study that evaluates the diagnostic reliability of CSF outflow resistance. Patients were assessed by a gait scale consisting of 10 features of walking and the number of steps and seconds necessary for 10 m, a d...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1997.tb00297.x

    authors: Boon AJ,Tans JT,Delwel EJ,Egeler-Peerdeman SM,Hanlo PW,Wurzer JA,Hermans J

    更新日期:1997-01-01 00:00:00

  • Rapidly reversible dementia in cerebral amyloid inflammatory vasculopathy.

    abstract::This report discusses a biopsy proven case of cerebral amyloid angiopathy, with additional prominent vascular inflammatory features, characterized by a rapidly progressive dementia and leukoencephalopathy, where the clinical and radiological abnormalities resolved rapidly with minimal therapeutic intervention. We prop...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1351-5101.2003.00707.x

    authors: Harkness KA,Coles A,Pohl U,Xuereb JH,Baron JC,Lennox GG

    更新日期:2004-01-01 00:00:00

  • An unusual case of Lafora body disease.

    abstract::A case is described in which non-convulsive status epilepticus (NCSE) prompted further investigation leading to the diagnosis of Lafora body disease (LBD). The onset of NCSE was temporally related to the withdrawal of sodium valproate and introduction of carbamazepine, which may have been precipitating factors. NCSE h...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1999.tb00021.x

    authors: Corkill RG,Hardie RJ

    更新日期:1999-03-01 00:00:00

  • European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie

    abstract:BACKGROUND:Paraprotein-associated neuropathies have heterogeneous clinical, neurophysiological, neuropathological and haematological features. Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic de...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01467.x

    authors: European Federation of Neurological Societies.,Peripheral Nerve Society.,Hadden RD,Nobile-Orazio E,Sommer C,Hahn A,Illa I,Morra E,Pollard J,Hughes RA,Bouche P,Cornblath D,Evers E,Koski CL,Léger JM,Van den Bergh P,van Door

    更新日期:2006-08-01 00:00:00

  • Neurophysiological study of critical illness polyneuropathy and myopathy in mechanically ventilated children; additional aspects in paediatric critical illness comorbidities.

    abstract:BACKGROUND AND PURPOSE:Critical illness polyneuropathy and myopathy (CIP/CIM) is being increasingly recognized as a significant clinical problem in critically ill children especially if they have spent long periods in the intensive care unit. So the aim was to determine the frequency of CIP/CIM amongst mechanically ven...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13649

    authors: Thabet Mahmoud A,Tawfik MAM,Abd El Naby SA,Abo El Fotoh WMM,Saleh NY,Abd El Hady NMS

    更新日期:2018-07-01 00:00:00

  • Prospective real-world analysis of OnabotulinumtoxinA in chronic migraine post-National Institute for Health and Care Excellence UK technology appraisal.

    abstract:BACKGROUND AND PURPOSE:The National Institute for Health and Care Excellence (NICE) in the UK recommends the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service. In view of the lack of data on the efficacy of this therapy...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13657

    authors: Andreou AP,Trimboli M,Al-Kaisy A,Murphy M,Palmisani S,Fenech C,Smith T,Lambru G

    更新日期:2018-08-01 00:00:00

  • No difference in efficacy of two different doses of intravenous immunoglobulins in MS: clinical and MRI assessment.

    abstract::We performed a double-blind, placebo-controlled study to evaluate the efficacy of low and high dose of intravenous immunoglobulins (IVIG) in relapsing/remitting (RR) multiple sclerosis (MS). Patients (n = 49) with clinical definite RR MS were randomly allocated to three groups and treated with 0.2 g/kg (n = 17) or 0.4...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1468-1331.2002.00500.x

    authors: Lewańska M,Siger-Zajdel M,Selmaj K

    更新日期:2002-11-01 00:00:00