Atrophy of optic nerve detected by transorbital sonography in patients with demyelinating diseases of the central nervous system.

abstract：:Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries. No studies were identified from large areas of Europe, especially from the former eastern Europe (except the Baltic countries) and the eastern Mediterranean countries. Based...

journal_title：European journal of neurology

authors： Forsgren L,Beghi E,Oun A,Sillanpää M

更新日期：2005-04-01 00:00:00

abstract：:We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in acti...

journal_title：European journal of neurology

authors： Starkstein SE,Migliorelli R,Manes F,Tesón A,Petracca G,Chemerinski E,Sabe L,Leiguarda R

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (AL...

journal_title：European journal of neurology

authors： Jawaid A,Poon M,Strutt AM,Rice LK,McDowell EJ,Salamone AR,Qureshi SU,Simpson E,Appel SH,York MK,Schulz PE

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Non-Western immigrants to Norway acquire an increased risk of multiple sclerosis (MS) after migration. Ethnicity and the presence of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) might influence the disease course. The aim of this study was to investigate differences in disease severi...

journal_title：European journal of neurology

authors： Berg-Hansen P,Smestad C,Sandvik L,Harbo HF,Celius EG

更新日期：2013-12-01 00:00:00

abstract：:The aim of our study was to analyse clinical and paraclinical characteristics of patients with multiple sclerosis (MS) with previous diagnosis of primary-progressive (PP) MS according to the Poser's criteria and further investigate if they fulfil the McDonald's diagnostic criteria for this disorder. A total of 561 MS ...

journal_title：European journal of neurology

authors： Dujmović I,Mesaros S,Pekmezović T,Lević Z,Drulović J

更新日期：2004-07-01 00:00:00

abstract：:We report a long-term outcome of motor function in a patient with adult-onset adrenoleukodystrophy after bone marrow transplantation (BMT). Clinically motor function gradually improved and became almost normal in 2 years after BMT. Serial transcranial magnetic stimulation showed gradual improvement of central motor co...

journal_title：European journal of neurology

authors： Hitomi T,Mezaki T,Tomimoto H,Ikeda A,Shimohama S,Okazaki T,Uchiyama T,Shibasaki H

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder with varied prevalence in different populations, which may be associated with specific haplotypes. This study aimed to explore the haplotypes encompassing the HTT gene in the Chinese population. METHODS:A total of 406...

journal_title：European journal of neurology

authors： Li XY,Li HL,Dong Y,Gao B,Cheng HR,Ni W,Gan SR,Liu ZJ,Burgunder JM,Wu ZY

更新日期：2020-02-01 00:00:00

abstract：:The diagnosis of mitochondrial encephalomyopathies is complex and a system for classification of the diagnosis as definite, probable, and possible has been proposed. The objective of this study was to explore the spectrum of epileptic disorders associated with probable and definite mitochondrial disease in children us...

journal_title：European journal of neurology

authors： Sadleir LG,Connolly MB,Applegarth D,Hendson G,Clarke L,Rakshi C,Farrell K

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To assess the efficacy and safety of olesoxime, a molecule with neuroprotective properties, in patients with amyotrophic lateral sclerosis (ALS) treated with riluzole. METHODS:A double-blind, randomized, placebo-controlled, multicenter trial of 18 months' duration was conducted in 512 subjects, ...

journal_title：European journal of neurology

authors： Lenglet T,Lacomblez L,Abitbol JL,Ludolph A,Mora JS,Robberecht W,Shaw PJ,Pruss RM,Cuvier V,Meininger V,Mitotarget study group.

更新日期：2014-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and potentially highly disabling disorder with considerable social impact and economic consequences. It is the major cause of non-traumatic disability in young adults. The social costs associated with MS are high because of its long duration, the early loss of productivity, the nee...

journal_title：European journal of neurology

authors： Pugliatti M,Rosati G,Carton H,Riise T,Drulovic J,Vécsei L,Milanov I

更新日期：2006-07-01 00:00:00

abstract：:Autosomal dominant cerebellar ataxias (ADCAs) are a complex group of slowly progressive neurodegenerative disorders characterized by gait and stance ataxia, dysarthria and other symptoms of nervous system involvement. ADCA type I is the commonest form and is genetically heterogeneous; several loci have been identified...

journal_title：European journal of neurology

authors： Giuffrida S,Lanza S,Restivo DA,Saponara R,Valvo SC,Le Pira F,Trovato Salinaro A,Spinella F,Nicoletti A,Condorelli DF

更新日期：1999-05-01 00:00:00

abstract：:We describe a patient who, three years after the onset of an olivopontocerebellar atrophy, developed a right cerebral tumour. The cerebellar symptomatology also included, as in other cerebellar patients previously described, a peripheral dysgraphia. Because this deficit of writing is generally reported in patients wit...

journal_title：European journal of neurology

authors： Silveri MC,Misciagna S,Laudisio A,Colosimo C

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease that may lead to disability and whose phenotype modulators are still unknown. METHODS:In the MIcrovascular LEukoencephalopathy Study (MILES), we asse...

journal_title：European journal of neurology

authors： Ciolli L,Pescini F,Salvadori E,Del Bene A,Pracucci G,Poggesi A,Nannucci S,Valenti R,Basile AM,Squarzanti F,Bianchi S,Dotti MT,Adriano E,Balestrino M,Federico A,Gandolfo C,Inzitari D,Pantoni L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ataxia-telangiectasia (A-T) is a rare neurodegenerative disease, due to A-T mutated (ATM) gene mutations, which typically presents with signs of progressive neurological dysfunction, cerebellar ataxia and uncoordinated movements. A-T severely affects patients' quality of life. Successful treatmen...

journal_title：European journal of neurology

authors： Cirillo E,Del Giudice E,Micheli R,Cappellari AM,Soresina A,Dellepiane RM,Pietrogrande MC,Dell'Era L,Specchia F,Pession A,Plebani A,Pignata C

更新日期：2018-06-01 00:00:00

abstract：:The present review of epidemiologic studies on migraine and headache in Europe is part of a larger initiative by the European Brain Council to estimate the costs incurred because of brain disorders. Summarizing the data on 1-year prevalence, the proportion of adults in Europe reporting headache was 51%, migraine 14%, ...

journal_title：European journal of neurology

authors： Stovner LJ,Zwart JA,Hagen K,Terwindt GM,Pascual J

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Falling is considered an important public health problem among older people. A recent cross-sectional study suggested that cognitive frailty (CF) is associated with falls. We aimed to explore whether CF is a risk factor for falls in a population-based longitudinal study. METHODS:Using data from ...

journal_title：European journal of neurology

authors： Ma Y,Li X,Pan Y,Zhao R,Wang X,Jiang X,Li S

更新日期：2021-02-01 00:00:00

abstract：:Among patients who underwent cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) examination during a 5-year period, we found 18 patients at the multiple sclerosis center of the University of Rome and clinically definite multiple sclerosis, MRI white matter abnormalities, normal CSF examination, a disease d...

journal_title：European journal of neurology

authors： Fieschi C,Gasperini C,Ristori G,Bastianello S,Girmenia F,Leuzzi V,Buttinelli C,Pozzilli C,Rasura M

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intrathecal immunoglobulin (Ig) synthesis occurs in various chronic inflammatory neurological diseases. Different formulae have been developed for quantitative determination of Ig synthesis within the cerebrospinal fluid (CSF) compartment. The hyperbolic formula of Reiber is frequently used which...

journal_title：European journal of neurology

authors： Auer M,Hegen H,Zeileis A,Deisenhammer F

更新日期：2016-04-01 00:00:00

abstract：:A 76-year-old man insidiously developed diffuse neurological symptoms: cognitive decline, dysphagia, dysphasia and mental disturbance. Computed tomography of the cranium revealed widespread bilateral brain edema and symmetrical bilateral sphenoid wing hyperostosis. Adjacent to the hyperostosis that resembled skull bas...

journal_title：European journal of neurology

authors： Lindsberg PJ,Tatlisumak T,Tienari J,Brander A

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Migraine with aura (MA) has been found to be a risk factor for cardiovascular disease including ischaemic stroke and myocardial infarction. Studies have also reported a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting as to whether this is r...

journal_title：European journal of neurology

authors： Winsvold BS,Hagen K,Aamodt AH,Stovner LJ,Holmen J,Zwart JA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that cause...

journal_title：European journal of neurology

authors： García-Martín E,Martínez C,Benito-León J,Calleja P,Díaz-Sánchez M,Pisa D,Alonso-Navarro H,Ayuso-Peralta L,Torrecilla D,Agúndez JA,Jiménez-Jiménez FJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type....

journal_title：European journal of neurology

authors： Song TJ,Kim J,Kim YD,Nam HS,Lee HS,Nam CM,Heo JH

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuromelanin of the brainstem, which is considered a marker of neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate the NM-MRI features of de novo PD and to determine whether these feat...

journal_title：European journal of neurology

authors： Wang J,Li Y,Huang Z,Wan W,Zhang Y,Wang C,Cheng X,Ye F,Liu K,Fei G,Zeng M,Jin L

更新日期：2018-07-01 00:00:00

abstract：:We here present the case of a patient with a sleep disturbance attributed to the exploding head syndrome, recently redefined as 'episodic cranial sensory shock'. The patient, who suffered with concomitant migraine, was treated for headache prevention with daily single-pulse transcranial magnetic stimulation. Following...

journal_title：European journal of neurology

authors： Puledda F,Moreno-Ajona D,Goadsby PJ

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND AND PURPOSE:Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies. METHODS:...

journal_title：European journal of neurology

authors： Deschamps R,Gueguen A,Lecler A,Lecouturier K,Lamirel C,Bensa C,Marignier R,Vignal C,Gout O

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lower urinary tract symptoms (LUTS) including frequent urination, nocturia and urge urinary incontinence negatively impact quality of life. This project aimed at characterizing the prevalence and severity of urinary incontinence in multiple sclerosis (MS) patients and its association with demogra...

journal_title：European journal of neurology

authors： Zecca C,Riccitelli GC,Disanto G,Singh A,Digesu GA,Panicari L,Puccini F,Mattioli M,Tubaro A,Gobbi C

更新日期：2016-07-01 00:00:00

abstract：:While pathological crying has classically been described as a disturbance of the motor concomitants of emotional affect that is unrelated to mood, recent studies indicate that there may in fact be a correlation. We therefore undertook a study of post-stroke pathological crying in relation to mood score/depression and ...

journal_title：European journal of neurology

authors： Andersen G,Vestergaard K,Ingeman-Nielsen M

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Information about metabolic comorbidities in patients with multiple sclerosis (MS) is scarce. Our aim was to examine the prevalence of the metabolic syndrome (MetS) and its components in patients with long duration of MS and significant disability. METHODS:Demographic and clinical data, weight, ...

journal_title：European journal of neurology

authors： Pinhas-Hamiel O,Livne M,Harari G,Achiron A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Many patients with multiple sclerosis (MS) present swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, has a profound impact on the quality of life but is under-reported by patients. The objective was to investigate the psychometric properties of the Dysphag...

journal_title：European journal of neurology

authors： Printza A,Boziki M,Bakirtzis C,Nikolaidis I,Kalaitzi M,Triaridis S,Grigoriadis N

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim was to explore the risk of early stroke recurrence within 3 months after watershed infarction and to investigate whether early dual antiplatelet therapy is more effective in decreasing such risk. METHODS:Patients enrolled in the Clopidogrel in High-risk Patients with Acute Non-disabling ...

journal_title：European journal of neurology

authors： Pu Y,Liu X,Wang Y,Meng X,Jing J,Zou X,Pan Y,Wang A,Zhao X,Johnston SC,Wang Y,Atchaneeyasakul K,Liebeskind DS,Liu L,CHANCE Investigators.

更新日期：2020-05-01 00:00:00