Abstract:
BACKGROUND AND PURPOSE:In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiatric symptoms in an Italian MS population during the COVID-19 lockdown, in order to identify potentially modifiable factors that could inform clinical management of mental distress in people with MS. METHODS:We explored the relationship between mental distress, disability and coping strategies in the Italian MS population under lockdown. Structural equation modeling was applied to information collected via web survey to identify modifiable factors that could account for mental distress. RESULTS:A total of 845 participants (497 with MS and 348 controls) were included in the study. The MS group had higher scores than the control group for depression (P = 0.005), but not for anxiety, emotional dyscontrol or sleep disturbances. The structural equation modeling explained 74% of the variance observed in depression score. Within the model, three latent factors were characterized from measured variables: motor disability and cognitive dysfunction contributed to disability (β = 0.509 and β = 0.836; P < 0.001); positive attitude and exercise contributed to active attitude (β = 0.386 and β = 0.297; P < 0.001); and avoidance, social support and watching television contributed to passive attitude (β = 0.301, β = 0.243 and β = 0.212; P < 0.001). With regard to the relationship between latent factors and their influence on depression, disability contributed to passive attitude (β = 0.855; P < 0.001), while both passive and active attitude significantly influenced depression (β = 0.729 and β = -0.456; P < 0.001). CONCLUSION:As a practical implication of our model, favoring exercise would enhance active attitude and its positive impact on mental well-being while, at the same time, reducing the negative impact of disability on depression, representing a valuable tool in facing COVID-19-related mental distress.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Costabile T,Carotenuto A,Lavorgna L,Borriello G,Moiola L,Inglese M,Petruzzo M,Trojsi F,Ianniello A,Nozzolillo A,Cellerino M,Boffa G,Rosa L,Servillo G,Moccia M,Bonavita S,Filippi M,Lanzillo R,Brescia Morra V,Petraccadoi
10.1111/ene.14580subject
Has Abstractpub_date
2020-10-11 00:00:00eissn
1351-5101issn
1468-1331pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Depressed mood is a common psychiatric problem associated with Parkinson's disease (PD), and studies have suggested a benefit of rasagiline treatment. METHODS:ACCORDO (see the ) was a 12-week, double-blind, placebo-controlled trial to evaluate the effects of rasagiline 1 mg/day on depressive sym...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12724
更新日期:2015-08-01 00:00:00
abstract::To evaluate prevalence of use and prescribing patterns of antiepileptic drugs (AEDs) in Italian general practice. Primary care data were obtained from the Health Search Database, a longitudinal observational database implemented by the Italian College of General Practitioners (GPs). We selected 465 061 subjects regist...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01970.x
更新日期:2007-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13260
更新日期:2017-04-01 00:00:00
abstract::The aim of our study was to analyse clinical and paraclinical characteristics of patients with multiple sclerosis (MS) with previous diagnosis of primary-progressive (PP) MS according to the Poser's criteria and further investigate if they fulfil the McDonald's diagnostic criteria for this disorder. A total of 561 MS ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2004.00797.x
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abstract:BACKGROUND AND PURPOSE:The purpose was to identify statistically factors that correlate with the presence of a colony-stimulating factor 1 receptor (CSF1R) mutation and to reevaluate the accuracy of the current diagnostic criteria for CSF1R-related leukoencephalopathy. METHODS:CSF1R testing was conducted on 145 consec...
journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2010.03171.x
更新日期:2011-03-01 00:00:00
abstract::Neuropathic pain treatment remains unsatisfactory despite a substantial increase in the number of trials. This EFNS Task Force aimed at evaluating the existing evidence about the pharmacological treatment of neuropathic pain. Studies were identified using first the Cochrane Database then Medline. Trials were classifie...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2006.01511.x
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Efficacy and safety data have not previously been compiled for intramuscular interferon beta-1a (IM IFNβ-1a) in patients with multiple sclerosis (MS) ≥ 50 years of age. We investigated the efficacy and safety of IM IFNβ-1a in patients segregated by 50 and 40 years of age in separate meta-analyses. METHODS:T...
journal_title:European journal of neurology
pub_type: 杂志文章,meta分析
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更新日期:2012-01-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03054.x
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1331.2009.02739.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01467.x
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2008.02057.x
更新日期:2008-04-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of neurology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2004-08-01 00:00:00
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更新日期:2013-01-01 00:00:00
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pub_type: 传,历史文章,杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 信件
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