当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NEUROLOGY期刊下所有文献 > Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis.

Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis.

Abstract：

BACKGROUND AND PURPOSE:Brain atrophy is related to clinical deterioration in multiple sclerosis (MS) but its association with intrathecal markers of inflammation or neurodegeneration is unclear. Our aim was to investigate whether cerebrospinal fluid (CSF) markers of inflammation or neurodegeneration are associated with brain volume change in natalizumab-treated MS and whether this change is reflected in non-lesional white matter metabolites. METHODS:About 25 patients with natalizumab-treated MS were followed for 3 years with assessment of percentage brain volume change (PBVC) and absolute quantification of metabolites with proton magnetic resonance spectroscopy (1 H MRS). Analyses of inflammatory [interleukin 1β (IL-1β), IL-6, C-X-C motif chemokine 8 (CXCL8), CXCL10, CXCL11, C-C motif chemokine 22] and neurodegenerative [neurofilament light protein (NFL), glial fibrillary acidic protein, myelin basic protein, tau proteins] markers were done at baseline and 1-year follow-up. RESULTS:The mean decline in PBVC was 3% at the 3-year follow-up, although mean 1 H MRS metabolite levels in non-lesional white matter were unchanged. CSF levels of NFL and tau at baseline correlated negatively with PBVC over 3 years (r = -0.564, P = 0.012, and r = -0.592, P = 0.010, respectively). CONCLUSIONS:A significant 3-year whole-brain atrophy was not reflected in mean metabolite change of non-lesional white matter. In addition, our results suggest that CSF levels of NFL and tau correlate with brain atrophy development and may be used for evaluating treatment response in inflammatory active MS.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Mellergård J,Tisell A,Blystad I,Grönqvist A,Blennow K,Olsson B,Dahle C,Vrethem M,Lundberg P,Ernerudh J

doi

10.1111/ene.13162

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

112-121

issue

1

eissn

1351-5101

issn

1468-1331

journal_volume

24

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF NEUROLOGY文献大全
  • Cutaneous manifestations in Moyamoya angiopathy: a review.

    abstract：:Moyamoya angiopathy (MA) is a progressive cerebrovascular disease with a poorly understood pathophysiology. It is mainly characterized by progressive bilateral stenosis of the terminal intracranial part of the supraclinoid internal carotid arteries and the proximal parts of the middle and anterior cerebral arteries, a...

    journal_title：European journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1111/ene.14754

    authors： Mitri F,Bersano A,Hervé D,Kraemer M

    更新日期：2021-01-23 00:00:00

  • High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis.

    abstract：BACKGROUND: Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against the acethylcholine receptor (AchR) of the neuromuscular junction in the majority of patients. METHODS: Here, we examined IgG antibodies against the type 1 nuclear antigen of Epstein-Barr virus (EBNA-1) in the sera of 158 patien...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2011.03636.x

    authors： Csuka D,Banati M,Rozsa C,Füst G,Illes Z

    更新日期：2012-06-01 00:00:00

  • Comparing ischaemic stroke in six European countries. The EuroHOPE register study.

    abstract：BACKGROUND AND PURPOSE:The incidence of hospitalizations, treatment and case fatality of ischaemic stroke were assessed utilizing a comprehensive multinational database to attempt to compare the healthcare systems in six European countries, aiming also to identify the limitations and make suggestions for future improve...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.12560

    authors： Malmivaara A,Meretoja A,Peltola M,Numerato D,Heijink R,Engelfriet P,Wild SH,Belicza É,Bereczki D,Medin E,Goude F,Boncoraglio G,Tatlisumak T,Seppälä T,Häkkinen U

    更新日期：2015-02-01 00:00:00

  • Prodrome in relapsing-remitting and primary progressive multiple sclerosis.

    abstract：BACKGROUND AND PURPOSE:The multiple sclerosis prodrome remains poorly understood. We aimed to examine the prodrome in people with relapsing remitting multiple sclerosis at onset (RMS) and primary progressive multiple sclerosis (PPMS). METHODS:We conducted a matched cohort study using clinical and linked health adminis...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13925

    authors： Wijnands JMA,Zhu F,Kingwell E,Zhao Y,Evans C,Fisk JD,Marrie RA,Tremlett H

    更新日期：2019-07-01 00:00:00

  • Subthreshold depression and subjective cognitive complaints in Parkinson's disease.

    abstract：BACKGROUND AND PURPOSE:Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demen...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.12219

    authors： Santangelo G,Vitale C,Trojano L,Angrisano MG,Picillo M,Errico D,Agosti V,Grossi D,Barone P

    更新日期：2014-03-01 00:00:00

  • SOD1 p.D12Y variant is associated with amyotrophic lateral sclerosis/distal myopathy spectrum.

    abstract：BACKGROUND AND PURPOSE:The aim of our study was to describe patients with the p.D12Y variant (previously reported as D11Y) in SOD1 showing heterogeneous clinicopathological features. METHODS:We performed clinical, electrophysiological, magnetic resonance imaging (MRI) and muscle pathology studies in four SOD1 p.D12Y v...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14246

    authors： Tasca G,Lattante S,Marangi G,Conte A,Bernardo D,Bisogni G,Mandich P,Zollino M,Ragozzino E,Udd B,Sabatelli M

    更新日期：2020-07-01 00:00:00

  • Measuring changes in the optic nerve sheath diameter in patients with idiopathic normal-pressure hydrocephalus: a useful diagnostic supplement to spinal tap tests.

    abstract：BACKGROUND AND PURPOSE:Cerebrospinal fluid (CSF) removal improves clinical symptoms of many patients with idiopathic normal-pressure hydrocephalus (iNPH). The aim of this study was to investigate the correlation of changes in the optic nerve sheath diameter (ONSD) with patient responses to CSF removal. METHODS:Transor...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13225

    authors： Ertl M,Aigner R,Krost M,Karnasová Z,Müller K,Naumann M,Schlachetzki F

    更新日期：2017-03-01 00:00:00

  • Treadmill training with partial body weight support and physiotherapy in stroke patients: a preliminary comparison.

    abstract：:Treadmill training with partial body weight support can restore the gait ability of chronic non-ambulatory hemiparetic subjects. A combination of physiotherapy and treadmill training may accelerate the rate of recovery. Therefore a randomized study was planned. Twenty-eight non-ambulatory hemiparetic patients were ran...

    journal_title：European journal of neurology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1468-1331.2002.00492.x

    authors： Werner C,Bardeleben A,Mauritz KH,Kirker S,Hesse S

    更新日期：2002-11-01 00:00:00

  • Intrafusal effects of botulinum toxin in post-stroke upper limb spasticity.

    abstract：:A previous study in subjects with focal dystonia suggested that the greater and longer-lasting effect induced by botulinum toxin type A (BoNT-A) on the tonic vibration reflex (TVR) than on the maximal M-wave (M-max) might be the physiological marker of the toxin's action at the level of intrafusal muscle fibres. With ...

    journal_title：European journal of neurology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1468-1331.2008.02076.x

    authors： Trompetto C,Bove M,Avanzino L,Francavilla G,Berardelli A,Abbruzzese G

    更新日期：2008-04-01 00:00:00

  • Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study.

    abstract：BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high morbidity and mortality. Minocycline is a matrix metalloproteinase-9 (MMP-9) inhibitor that may attenuate secondary mechanisms of injury in ICH. The feasibility and safety of minocycline in ICH patients were evalua...

    journal_title：European journal of neurology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/ene.13403

    authors： Chang JJ,Kim-Tenser M,Emanuel BA,Jones GM,Chapple K,Alikhani A,Sanossian N,Mack WJ,Tsivgoulis G,Alexandrov AV,Pourmotabbed T

    更新日期：2017-11-01 00:00:00

  • Neurological involvement in antiphospholipid syndrome: clinical and instrumental evaluation in 21 consecutive cases.

    abstract：:Twenty-one consecutive women with the antiphospholipid syndrome were investigated with a full cardiological and neurological examination including a semi-structured interview. They were also systematically studied with magnetic resonance imaging (MRI), transcranial Doppler (TCD), duplex sonography of neck vessels and ...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.1995.tb00119.x

    authors： Anzola GP,Tincani A,Magoni M,Spatola L,Bonetti A

    更新日期：1995-07-01 00:00:00

  • Impairment of short-term memory and Korsakoff syndrome are common in AIDS patients with cytomegalovirus encephalitis.

    abstract：BACKGROUND AND PURPOSE:The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV di...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2008.02337.x

    authors： Pirskanen-Matell R,Grützmeier S,Nennesmo I,Sandström E,Ehrnst A

    更新日期：2009-01-01 00:00:00

  • Hyperhomocysteinemia recurrence in levodopa-treated Parkinson's disease patients.

    abstract：BACKGROUND:Patients with Parkinson's disease (PD) and chronically treated with L-DOPA exhibit, in a percentage of 10-30%, supra-physiological levels of plasma total homocysteinemia (tHcy). In this study, we have investigated, in a group of hyper-homocysteinemic PD patients, the time of hyper-tHcy recurrence after disco...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2009.02894.x

    authors： Belcastro V,Pierguidi L,Castrioto A,Menichetti C,Gorgone G,Ientile R,Pisani F,Rossi A,Calabresi P,Tambasco N

    更新日期：2010-05-01 00:00:00

  • Minimal clinically important differences in functional motor scores in adults with spinal muscular atrophy.

    abstract：BACKGROUND AND PURPOSE:In patients with spinal muscular atrophy (SMA), functional disease scores are frequently used to evaluate the course of the disease and the efficacy of treatment. The aim of the present study was to propose minimal clinically important difference (MCID) values for motor scores in order to estimat...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14472

    authors： Stolte B,Bois JM,Bolz S,Kizina K,Totzeck A,Schlag M,Kleinschnitz C,Hagenacker T

    更新日期：2020-12-01 00:00:00

  • Neuromelanin-sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes.

    abstract：BACKGROUND AND PURPOSE:Neuromelanin of the brainstem, which is considered a marker of neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate the NM-MRI features of de novo PD and to determine whether these feat...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13628

    authors： Wang J,Li Y,Huang Z,Wan W,Zhang Y,Wang C,Cheng X,Ye F,Liu K,Fei G,Zeng M,Jin L

    更新日期：2018-07-01 00:00:00

  • Encephalopathy and biopsy-proven cerebrovascular inflammatory changes in a cocaine abuser.

    abstract：:Cocaine abuse is a well known cause of cerebrovascular complications. An inflammatory vasculopathy hypothesis has been proposed, but the medical literature has only reported a few pathological confirmations. We report a case with a biopsy demonstrating cerebral inflammatory vascular changes that are associated with co...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1046/j.1468-1331.1998.510103.x

    authors： Diez-Tejedor E,Frank A,Gutierrez M,Barreiro P

    更新日期：1998-01-01 00:00:00

  • Cerebral vasospasm in acute porphyria.

    abstract：BACKGROUND AND PURPOSE:Porphyrias are a group of inherited metabolic disorders resulting from a specific deficiency along the pathway of haem biosynthesis. A clinical classification distinguishes acute from non-acute porphyrias considering the occurrence of life-threatening neurovisceral attacks, presenting with abdomi...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13347

    authors： Olivier P,Van Melkebeke D,Honoré PJ,Defreyne L,Hemelsoet D

    更新日期：2017-09-01 00:00:00

  • KCNN2 mutation in autosomal-dominant tremulous myoclonus-dystonia.

    abstract：BACKGROUND AND PURPOSE:Despite recent advances in neurogenetics that have facilitated the identification of a number of dystonia genes, many familial dystonia syndromes remain without known cause. The aim of the study was to identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affe...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14228

    authors： Balint B,Guerreiro R,Carmona S,Dehghani N,Latorre A,Cordivari C,Bhatia KP,Bras J

    更新日期：2020-08-01 00:00:00

  • Prevalence and immunological spectrum of temporal lobe epilepsy with glutamic acid decarboxylase antibodies.

    abstract：BACKGROUND AND PURPOSE:High levels of glutamic acid decarboxylase (GAD)-ab were initially described in patients with stiff person syndrome, and have since also been observed in patients with other neurological diseases. Temporal lobe epilepsy (TLE) seems to be specially associated. Our purpose is to describe the preval...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2011.03609.x

    authors： Falip M,Carreño M,Miró J,Saiz A,Villanueva V,Quílez A,Molins A,Barceló I,Sierra A,Graus F

    更新日期：2012-06-01 00:00:00

  • Malondialdehyde, glutathione peroxidase and superoxide dismutase in peripheral blood erythrocytes of patients with acute cerebral ischemia.

    abstract：:The levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1) were measured in the red blood cells (RBC) of 34 patients with acute ischemic hemispheric stroke on the first and seventh day after their stroke onset, and compared with 30 control individuals matched for sex, age and...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1046/j.1468-1331.2001.00166.x

    authors： Demirkaya S,Topcuoglu MA,Aydin A,Ulas UH,Isimer AI,Vural O

    更新日期：2001-01-01 00:00:00

  • Cranial nerve involvement in typical and atypical chronic inflammatory demyelinating polyneuropathies.

    abstract：BACKGROUND AND PURPOSE:Cranial nerve palsy is occasionally present in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), but its prevalence, characteristics and relations with the CIDP subtypes have rarely been investigated. The aim of this study was to systematically assess cranial nerve involveme...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14497

    authors： Shibuya K,Tsuneyama A,Misawa S,Suichi T,Suzuki Y,Kojima Y,Nakamura K,Kano H,Prado M,Kuwabara S

    更新日期：2020-12-01 00:00:00

  • Subacute rhombencephalitis optica responsive to intravenous immunoglobulins.

    abstract：:A 53-year-old man presented with optic neuritis, followed within 10 weeks by a subacute progression of weakness, ataxia, and multiple cranial nerve palsies. Cranial magnetic resonance imaging demonstrated multiple T2-hyperintense lesions extending from the ponto-medullary junction to the thalamus and internal capsule....

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1046/j.1468-1331.2003.00543.x

    authors： Zivković SA,Heyman R,Pless M

    更新日期：2003-01-01 00:00:00

  • Arterial mechanisms in the pathophysiology of migraine headache-implications for modern therapy.

    abstract：:Studies of the cephalic vascular system have markedly contributed towards an understanding of the mechanisms of migraine pain. Whereas cerebral blood flow changes, and thereby changes in the arterioles, correlate poorly with migraine headache, abnormal regulation of the large cranial arteries seems to play a significa...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.1995.tb00149.x

    authors： Thomsen LL

    更新日期：1995-11-01 00:00:00

  • A prospective study of "undiagnosed" isolated myelopathy: I. Case selection and clinical features.

    abstract：:We aimed to carry out a study of isolated, unexplained myelopathy which avoided as far as possible selection and referral bias. We used a prospective design with case ascertainment from both neurological and neurosurgical referrals. We wanted to establish the sensitivity, predictive value and possible redundancy of cu...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.1995.tb00131.x

    authors： Blumhardt LD,Sandercock PA,Moore AP,Woodrow J,Findlay G

    更新日期：1995-09-01 00:00:00

  • Parkinson's disease and nursing home placement: the economic impact of the need for care.

    abstract：BACKGROUND AND PURPOSE:To examine the relative risk (RR) for living in nursing homes for patients with Parkinson's disease (PD) compared with the general population and to ascertain society's costs related to nursing home placement for this patient group. METHODS:We evaluated the frequency of admission to nursing home...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2008.02380.x

    authors： Vossius C,Nilsen OB,Larsen JP

    更新日期：2009-02-01 00:00:00

  • Factors predictive of the presence of a CSF1R mutation in patients with leukoencephalopathy.

    abstract：BACKGROUND AND PURPOSE:The purpose was to identify statistically factors that correlate with the presence of a colony-stimulating factor 1 receptor (CSF1R) mutation and to reevaluate the accuracy of the current diagnostic criteria for CSF1R-related leukoencephalopathy. METHODS:CSF1R testing was conducted on 145 consec...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14086

    authors： Kondo Y,Matsushima A,Nagasaki S,Nakamura K,Sekijima Y,Yoshida K

    更新日期：2020-02-01 00:00:00

  • Peritumoral edema on MRI at initial diagnosis: an independent prognostic factor for glioblastoma?

    abstract：BACKGROUND:Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral edema as a prognostic factor is controversial. MATERIALS AND METHODS:This multi-centre clinical retrospective study included 110 patie...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2009.02613.x

    authors： Schoenegger K,Oberndorfer S,Wuschitz B,Struhal W,Hainfellner J,Prayer D,Heinzl H,Lahrmann H,Marosi C,Grisold W

    更新日期：2009-07-01 00:00:00

  • Early neurological deterioration following thrombolysis for minor stroke with isolated internal carotid artery occlusion.

    abstract：BACKGROUND AND PURPOSE:Better understanding the incidence, predictors and mechanisms of early neurological deterioration (END) following intravenous thrombolysis (IVT) for acute stroke with mild symptoms and isolated internal carotid artery occlusion (iICAo) may inform therapeutic decisions. METHODS:From a multicenter...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14541

    authors： Boulenoir N,Turc G,Henon H,Laksiri N,Mounier-Véhier F,Girard Buttaz I,Duong DL,Papassin J,Yger M,Triquenot A,Lyoubi A,Ter Schiphorst A,Denier C,Baron JC,Seners P,MINOR-STROKE Collaborators.

    更新日期：2021-02-01 00:00:00

  • Hepatic metastasis of thymoma.

    abstract：:The natural history of thymoma remains unpredictable because of the possibility of recurrence not infrequent after resection, but generally confined to the mediastinum Rufini et al. (1997). ...

    journal_title：European journal of neurology

    pub_type： 信件

    doi：10.1046/j.1468-1331.2000.00023.x

    authors： Moretti R,Nasuelli D,Torre P,Antonello RM,Cazzato G,Stanta G

    更新日期：2000-01-01 00:00:00

  • Cerebral vasomotor reactivity of bilateral severe carotid stenosis: is stroke unavoidable?

    abstract：:We evaluated the cerebral hemodynamic features of severe bilateral carotid stenosis by assessing and comparing cerebral vasomotor reactivity (VMR) in the middle cerebral (MCA) and vertebral arteries (VA) by transcranial Doppler and the Diamox (1 g acetazolamide i.v.) test. VMR was evaluated by recording the percentage...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2006.01160.x

    authors： Gur AY,Bornstein NM

    更新日期：2006-02-01 00:00:00