Subthreshold depression and subjective cognitive complaints in Parkinson's disease.

Abstract:

BACKGROUND AND PURPOSE:Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients. METHODS:Amongst 115 patients, SubD was identified in 30 patients, major depression in 33; 36 patients were classified as non-depressed. Enrolled patients were administered tests and questionnaires validated in PD for assessing objective and subjective cognitive dysfunctions. RESULTS:On objective cognitive measures SubD patients did not differ from non-depressed patients, whereas depressed patients achieved significantly lower scores than the other two groups. SubD and depressed patients reported more cognitive complaints than non-depressed patients. CONCLUSIONS:SubD is a non-motor aspect of PD that is not related to objective cognitive deficits but is associated with subjective cognitive complaints, thus impacting on patients' well-being.

journal_name

Eur J Neurol

authors

Santangelo G,Vitale C,Trojano L,Angrisano MG,Picillo M,Errico D,Agosti V,Grossi D,Barone P

doi

10.1111/ene.12219

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

541-4

issue

3

eissn

1351-5101

issn

1468-1331

journal_volume

21

pub_type

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