Serum soluble ST2 is a potential long-term prognostic biomarker for transient ischaemic attack and ischaemic stroke.

Abstract:

BACKGROUND AND PURPOSE:Soluble ST2 (sST2) is a promising biomarker in inflammation, atherosclerosis and cardiovascular diseases. We investigated the association between serum sST2 and poor outcome in patients with transient ischaemic attack (TIA)/ischaemic stroke. METHODS:Patients within 24 h after onset and with measured serum sST2 were prospectively enrolled in this study. Poor outcome was a combination of a new stroke event (ischaemic or haemorrhagic) and all-cause death within 90 days and 1 year. The associations of serum sST2 with poor outcome were analysed by Cox proportional hazards. RESULTS:Among the 430 patients included, the median (interquartile range) sST2 was 17.72 (9.31-28.84) ng/mL. A total of 19 (4.4%) and 38 (8.8%) patients experienced poor outcome within 90 days and 1 year, respectively. Compared with the lowest sST2 tertile, hazard ratios (HRs) [95% confidence intervals (CI)] for the highest tertile were 5.14 (1.43-18.51) for poor outcome within 90 days and 3.00 (1.29-6.97) at 1 year after multivariate adjustments. Adding sST2 to a prediction model significantly improved risk stratification of poor outcome in TIA/ischaemic stroke, as observed by the continuous net reclassification improvement of 60.98% (95% CI, 15.37-106.6%, P = 0.009) and integrated discrimination improvement of 2.63% (95% CI, 0.08-5.18%, P = 0.043) at 90 days and the continuous net reclassification improvement of 41.68% (95% CI, 8.74-74.61%, P = 0.013) at 1 year. CONCLUSIONS:Increased serum sST2 levels in TIA/ischaemic stroke were associated with increased risks of poor outcome within 90 days and 1 year, suggesting that serum sST2 may be a potential long-term prognostic biomarker for TIA/ischaemic stroke.

journal_name

Eur J Neurol

authors

Tian X,Guo Y,Wang X,Pei L,Wang X,Wu J,Sun S,Li Y,Ning M,Buonanno FS,Xu Y,Song B

doi

10.1111/ene.14419

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

2202-2208

issue

11

eissn

1351-5101

issn

1468-1331

journal_volume

27

pub_type

杂志文章
  • Sapienza Global Bedside Evaluation of Swallowing after Stroke: the GLOBE-3S study.

    abstract:BACKGROUND AND PURPOSE:Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13862

    authors: Toscano M,Viganò A,Rea A,Verzina A,Sasso D'Elia T,Puledda F,Longo L,Mancini V,Ruggiero M,Jannini TB,Giuliani G,Albino F,Altieri M,Vicenzini E,Fattapposta F,Pauri F,Giacomini P,Ruoppolo G,Di Piero V

    更新日期:2019-04-01 00:00:00

  • Reasons patients give to use or not to use immunomodulating agents for multiple sclerosis.

    abstract:BACKGROUND:Variations in the treatment of multiple sclerosis (MS) occur. This study was performed to obtain insight into the reasons why patients with MS use or do not use immunomodulating treatment (DMT). METHODS:We held a survey on the use of DMT in a group of 1572 patients with MS. RESULTS:Response rate was 89%. O...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03411.x

    authors: Visser LH,van der Zande A

    更新日期:2011-11-01 00:00:00

  • Neurophysiological study of critical illness polyneuropathy and myopathy in mechanically ventilated children; additional aspects in paediatric critical illness comorbidities.

    abstract:BACKGROUND AND PURPOSE:Critical illness polyneuropathy and myopathy (CIP/CIM) is being increasingly recognized as a significant clinical problem in critically ill children especially if they have spent long periods in the intensive care unit. So the aim was to determine the frequency of CIP/CIM amongst mechanically ven...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13649

    authors: Thabet Mahmoud A,Tawfik MAM,Abd El Naby SA,Abo El Fotoh WMM,Saleh NY,Abd El Hady NMS

    更新日期:2018-07-01 00:00:00

  • Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome.

    abstract:BACKGROUND AND PURPOSE:Embolic strokes of undetermined source (ESUS) are a recent entity, not yet thoroughly investigated in young stroke patients. The clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other aetiological subgroups were compared. METHOD...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13540

    authors: Martinez-Majander N,Aarnio K,Pirinen J,Lumikari T,Nieminen T,Lehto M,Sinisalo J,Kaste M,Tatlisumak T,Putaala J

    更新日期:2018-03-01 00:00:00

  • Left parietal cortex transcranial direct current stimulation enhances gesture processing in corticobasal syndrome.

    abstract:BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12748

    authors: Bianchi M,Cosseddu M,Cotelli M,Manenti R,Brambilla M,Rizzetti MC,Padovani A,Borroni B

    更新日期:2015-09-01 00:00:00

  • Facial myokymia in brain death.

    abstract:BACKGROUND:Brain death (BD) is the irreversible loss of all functions of the brain and brainstem. Spontaneous and reflex movements of the limbs have been described in this condition. However, facial myokymia (FM) in BD has not been previously reported. The origin of that motor phenomenon in alive patients is still unce...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2001.00208.x

    authors: Saposnik G,Mauriño J,Saizar R

    更新日期:2001-05-01 00:00:00

  • Pituitary apoplexy: a transient benign presentation mimicking mild subarachnoid hemorrhage with negative angiography.

    abstract::We report on a patient who presented with isolated transient headache as the only manifestation of pituitary apoplexy. A high index of suspicion and MRI led to the diagnosis. Copyright 1998 Lippincott Williams & Wilkins ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1998.550499.x

    authors: Hernandez A,Angeles Del Real M,Aguirre M,Vaamonde J,Gudin M,Ibanez R

    更新日期:1998-09-01 00:00:00

  • Urinary incontinence in multiple sclerosis: prevalence, severity and impact on patients' quality of life.

    abstract:BACKGROUND AND PURPOSE:Lower urinary tract symptoms (LUTS) including frequent urination, nocturia and urge urinary incontinence negatively impact quality of life. This project aimed at characterizing the prevalence and severity of urinary incontinence in multiple sclerosis (MS) patients and its association with demogra...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13010

    authors: Zecca C,Riccitelli GC,Disanto G,Singh A,Digesu GA,Panicari L,Puccini F,Mattioli M,Tubaro A,Gobbi C

    更新日期:2016-07-01 00:00:00

  • Therapeutic outcome in neuropathic pain: relationship to evidence of nervous system lesion.

    abstract::Treatment outcome in patients with neuropathic pain (NP) is often variable and disappointing. We tested the hypothesis that patients with clear evidence of nervous system lesion respond better to pharmacological treatment with documented effect on NP than patients with poor or no evidence of nervous system lesion. Fur...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1468-1331.2004.00843.x

    authors: Rasmussen PV,Sindrup SH,Jensen TS,Bach FW

    更新日期:2004-08-01 00:00:00

  • Post-stroke pathological crying: frequency and correlation to depression.

    abstract::While pathological crying has classically been described as a disturbance of the motor concomitants of emotional affect that is unrelated to mood, recent studies indicate that there may in fact be a correlation. We therefore undertook a study of post-stroke pathological crying in relation to mood score/depression and ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1995.tb00092.x

    authors: Andersen G,Vestergaard K,Ingeman-Nielsen M

    更新日期:1995-03-01 00:00:00

  • A descriptive study on constructional impairment in frontotemporal dementia and Alzheimer's disease.

    abstract:BACKGROUND AND PURPOSE:Frontotemporal dementia (FTD) is a degenerative disorder characterized, in its frontal variant, by psychiatric onset, deficits in executive functions and sparing of memory and visuo-spatial abilities. Studies on visuo-spatial abilities in FTD and Alzheimer's disease (AD) have mainly focused on co...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02128.x

    authors: Gasparini M,Masciarelli G,Vanacore N,Ottaviani D,Salati E,Talarico G,Lenzi GL,Bruno G

    更新日期:2008-06-01 00:00:00

  • A multicenter study of transient global amnesia for the better detection of magnetic resonance imaging abnormalities.

    abstract:BACKGROUND AND PURPOSE:The detection rate of diffusion-weighted (DWI) hyperintense lesions varies widely in patients with transient global amnesia (TGA). The aim was to examine the association of hyperintense lesions on DWI magnetic resonance imaging (MRI) with patient characteristics, precipitating factors, clinical p...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14408

    authors: Higashida K,Okazaki S,Todo K,Sasaki T,Ohara N,Kohara N,Yamamoto S,Yamagami H,Hashikawa K,Yoshimoto T,Ihara M,Koga M,Szabo K,Mochizuki H

    更新日期:2020-11-01 00:00:00

  • Acute autonomic dysfunction contralateral to acute strokes: a prospective study of 100 consecutive cases.

    abstract::Complex painful reflex syndrome is sometimes described in the chronic phase of stroke. Acute autonomic dysfunction (AAD), which is occasionally present in cases of acute stroke, has not been studied prospectively. The aim of the study was to investigate AAD on the hemibody contralateral to the lesion in the acute phas...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01488.x

    authors: Diserens K,Vuadens P,Michel P,Reichhart M,Herrmann FR,Arnold P,Bogousslavsky J,Ghika J

    更新日期:2006-11-01 00:00:00

  • Neuromelanin or DaT-SPECT: which is the better marker for discriminating advanced Parkinson's disease?

    abstract:BACKGROUND AND PURPOSE:Whether the neuromelanin-positive substantia nigra pars compacta area (NM-SNc) on neuromelanin magnetic resonance imaging (NM-MRI) and the specific binding ratio (SBR) on 123 I-N-v-fluoropropyl-2b-carbomethoxy3b-(4-iodophenyl)nortropane single photon emission computed tomography (DaT-SPECT) can b...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14009

    authors: Okuzumi A,Hatano T,Kamagata K,Hori M,Mori A,Oji Y,Taniguchi D,Daida K,Shimo Y,Yanagisawa N,Nojiri S,Aoki S,Hattori N

    更新日期:2019-11-01 00:00:00

  • EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.

    abstract:BACKGROUND:Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life. OBJECTIVES:To create practical guidelines for diagnosis, management and prevention of the disease. METHODS:We searched MEDLINE, EMBASE, LILACS, Cochrane Library. CONCLUSIONS AND REC...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1468-1331.2010.03153.x

    authors: Galvin R,Bråthen G,Ivashynka A,Hillbom M,Tanasescu R,Leone MA,EFNS.

    更新日期:2010-12-01 00:00:00

  • Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese.

    abstract:BACKGROUND:Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominan...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02376.x

    authors: Chan KH,Ramsden DB,Yu YL,Kwok KH,Chu AC,Ho PW,Kwan JS,Lee R,Lim E,Kung MH,Ho SL

    更新日期:2009-03-01 00:00:00

  • Chronic obstructive pulmonary disease as a risk factor for stroke-related seizures.

    abstract::Chronic obstructive pulmonary disease (COPD) is a risk factor for cardiovascular disorders and different types of stroke. The present retrospective study investigates whether COPD is also a risk factor for the development of seizures in stroke patients. The study population consisted of 237 patients with stroke-relate...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2007.01829.x

    authors: De Reuck J,Proot P,Van Maele G

    更新日期:2007-09-01 00:00:00

  • Does apolipoprotein E genotype modify the clinical expression of ALS?

    abstract:BACKGROUND:The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (AL...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03225.x

    authors: Jawaid A,Poon M,Strutt AM,Rice LK,McDowell EJ,Salamone AR,Qureshi SU,Simpson E,Appel SH,York MK,Schulz PE

    更新日期:2011-04-01 00:00:00

  • Follow-up study of cardiac ¹²³I-MIBG scintigraphy in idiopathic REM sleep behavior disorder.

    abstract:BACKGROUND:Cardiac (123) I-metaiodobenzylguanidine ((123) I-MIBG) uptake in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is markedly reduced, as in Parkinson's disease (PD). METHODS:We performed (123) I-MIBG scintigrams on patients with iRBD and PD. After the initial (123) I-MIBG sc...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03392.x

    authors: Miyamoto T,Miyamoto M,Iwanami M,Hirata K

    更新日期:2011-10-01 00:00:00

  • Diagnostic value of brain MRI and 18F-FDG PET in the differentiation of Parkinsonian-type multiple system atrophy from Parkinson's disease.

    abstract:BACKGROUND AND PURPOSE:Differentiation between parkinsonian type multiple system atrophy (MSA-P) and Parkinson's disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in diff...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02235.x

    authors: Kwon KY,Choi CG,Kim JS,Lee MC,Chung SJ

    更新日期:2008-10-01 00:00:00

  • Practice recommendations for neurovascular ultrasound investigations of acute stroke patients in the setting of the COVID-19 pandemic: an expert consensus from the European Society of Neurosonology and Cerebral Hemodynamics.

    abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke are at high-risk for contracting COVID-19 infection. Additionally, healthcare professionals including neurovascular ultrasound providers are also at risk of being infected by SARS-CoV-2 virus. Yet, preparedness to continue to guarantee hyperacute treatment is v...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/ene.14334

    authors: Baracchini C,Pieroni A,Kneihsl M,Azevedo E,Diomedi M,Pascazio L,Wojczal J,Lucas C,Bartels E,Bornstein NM,Csiba L,Valdueza J,Tsivgoulis G,Malojcic B

    更新日期:2020-09-01 00:00:00

  • Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Brain atrophy is related to clinical deterioration in multiple sclerosis (MS) but its association with intrathecal markers of inflammation or neurodegeneration is unclear. Our aim was to investigate whether cerebrospinal fluid (CSF) markers of inflammation or neurodegeneration are associated with...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13162

    authors: Mellergård J,Tisell A,Blystad I,Grönqvist A,Blennow K,Olsson B,Dahle C,Vrethem M,Lundberg P,Ernerudh J

    更新日期:2017-01-01 00:00:00

  • Onset and progression of primary torsion dystonia in sporadic and familial cases.

    abstract::Four hundred and sixty records of patients with primary torsion dystonia (296 women and 164 men) were evaluated. The mean age at disease onset was 48.3 +/- 17.7 years; 13 patients carried the DYT1 CAG deletion. The distribution of age at onset was represented by a bi-modal curve, with a nadir at 21 year separating ear...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01387.x

    authors: Elia AE,Filippini G,Bentivoglio AR,Fasano A,Ialongo T,Albanese A

    更新日期:2006-10-01 00:00:00

  • TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.

    abstract:BACKGROUND:Multiple mitochondrial DNA (mtDNA) deletions usually have a mendelian inheritance secondary to mutation in nuclear genes. One of these is the Twinkle gene whose mutation is responsible for autosomal dominant progressive external ophthalmoplegia (PEO). The number of reported cases with mainly myopathic sympto...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2010.03171.x

    authors: Martin-Negrier ML,Sole G,Jardel C,Vital C,Ferrer X,Vital A

    更新日期:2011-03-01 00:00:00

  • Medium-term functional benefits in children with cerebral palsy treated with botulinum toxin type A: 1-year follow-up using gross motor function measure.

    abstract::One of the main goals when treating spasticity is to relieve pain and improve function. Intramuscular injection of botulinum toxin type A (BTX-A) has gained widespread acceptance in the treatment of spastic cerebral palsy. Several studies have clearly shown the short-term functional benefit of BTX-A treatment. Informa...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1468-1331.2001.00044.x

    authors: Linder M,Schindler G,Michaelis U,Stein S,Kirschner J,Mall V,Berweck S,Korinthenberg R,Heinen F

    更新日期:2001-11-01 00:00:00

  • Encephalopathy and biopsy-proven cerebrovascular inflammatory changes in a cocaine abuser.

    abstract::Cocaine abuse is a well known cause of cerebrovascular complications. An inflammatory vasculopathy hypothesis has been proposed, but the medical literature has only reported a few pathological confirmations. We report a case with a biopsy demonstrating cerebral inflammatory vascular changes that are associated with co...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1998.510103.x

    authors: Diez-Tejedor E,Frank A,Gutierrez M,Barreiro P

    更新日期:1998-01-01 00:00:00

  • EFNS guideline on the drug treatment of migraine - report of an EFNS task force.

    abstract::Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/j.1468-1331.2006.01411.x

    authors: Members of the task force:.,Evers S,Afra J,Frese A,Goadsby PJ,Linde M,May A,Sándor PS

    更新日期:2006-06-01 00:00:00

  • Hyperhomocysteinaemia is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients.

    abstract::The presence of white matter lesions (WML) is an important prognostic factor for the development of stroke. Plasma total homocysteine (tHcy), which increases with diabetes, has been flagged as a novel predictor for cerebrovascular events. We tested the hypothesis that the presence of WML correlates with tHcy and insul...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02062.x

    authors: Shimomura T,Anan F,Umeno Y,Eshima N,Saikawa T,Yoshimatsu H,Fujiki M,Kobayashi H

    更新日期:2008-03-01 00:00:00

  • Total drug treatment and comorbidity in myasthenia gravis: a population-based cohort study.

    abstract:BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12439

    authors: Andersen JB,Owe JF,Engeland A,Gilhus NE

    更新日期:2014-07-01 00:00:00

  • A combination of total tau and neurofilaments discriminates between neurodegenerative and primary psychiatric disorders.

    abstract:BACKGROUND AND PURPOSE:Neuropsychiatric symptoms are commonly observed in neurodegenerative diseases. No biomarker is currently available to diagnose psychiatric conditions. As a consequence, the distinction between psychiatric and neurodegenerative disorders can be challenging in daily practice. METHODS:This retrospe...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14247

    authors: Fourier A,Formaglio M,Kaczorowski F,Mollion H,Perret-Liaudet A,Sauvee M,Quadrio I

    更新日期:2020-07-01 00:00:00