Abstract:
BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their everyday life. Transcranial direct current stimulation (tDCS) is a non-invasive procedure of cortical stimulation, which represents a promising tool for cognitive enhancement and neurorehabilitation. The present study investigated whether anodal tDCS over the parietal cortex (PARC), would improve ideomotor upper limb apraxia in CBS patients. METHODS:Fourteen patients with possible CBS and upper limb apraxia were enrolled. Each patient underwent two sessions of anodal tDCS (left and right PARC) and one session of placebo tDCS. Ideomotor upper limb apraxia was assessed using the De Renzi ideomotor apraxia test that is performed only on imitation. RESULTS:A significant improvement of the De Renzi ideomotor apraxia test scores (post-stimulation versus pre-stimulation) after active anodal stimulation over the left PARC was observed (χ(2) = 17.6, P = 0.0005), whilst no significant effect was noticed after active anodal stimulation over the right PARC (χ(2) = 7.2, P = 0.07). A post hoc analysis revealed a selective improvement in the De Renzi ideomotor apraxia score after active anodal stimulation over the left PARC compared with placebo stimulation considering both right (P = 0.03) and left upper limbs (P = 0.01). CONCLUSIONS:These findings indicate that tDCS to the PARC improves the performance of an ideomotor apraxia test in CBS patients and might represent a promising tool for future rehabilitation approaches.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Bianchi M,Cosseddu M,Cotelli M,Manenti R,Brambilla M,Rizzetti MC,Padovani A,Borroni Bdoi
10.1111/ene.12748subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1317-22issue
9eissn
1351-5101issn
1468-1331journal_volume
22pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Chronic syphilitic infection may lead to dementia. It is in general paresis (GP), which is the major late form of neurosyphilis, that cognitive impairment frequently occurs. The association between lipid metabolism and GP is unclear. METHODS:In this study, serum lipids were studied in 188 GP pat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13074
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Certain miscellaneous idiopathic headache disorders, which are regarded as entities, are grouped in Chapter 4 of the International Classification of Headache Disorders. Recent epidemiological research suggests that these headache disorders are underdiagnosed. OBJECTIVES:To give expert recommenda...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2011.03389.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Serotoninergic dysfunction was reported to be involved in aetiology of temporal lobe epilepsy (TLE). Serotonin (5-HT) is actively cleared from synaptic cleft by serotonin transporter (5-HTT). We investigated the association between three common polymorphisms of 5-HTT gene, which may influence gen...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03521.x
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abstract:BACKGROUND AND PURPOSE:Mutations in the PLA2G6 gene are causative of PLA2G6-associated neurodegeneration (PLAN), a spectrum of neurodegenerative conditions including infantile, childhood and adult onset forms. METHODS:Seventeen North African patients with a clinical suspicion of infantile-onset PLAN underwent clinical...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12552
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abstract::Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00208.x
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02128.x
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14228
更新日期:2020-08-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1995.tb00119.x
更新日期:1995-07-01 00:00:00
abstract::We report a long-term outcome of motor function in a patient with adult-onset adrenoleukodystrophy after bone marrow transplantation (BMT). Clinically motor function gradually improved and became almost normal in 2 years after BMT. Serial transcranial magnetic stimulation showed gradual improvement of central motor co...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2005.01055.x
更新日期:2005-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1999.660639.x
更新日期:1999-11-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03508.x
更新日期:2012-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.0090s1048.x
更新日期:2002-05-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2008-08-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1995.tb00149.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12227
更新日期:2013-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12053
更新日期:2013-09-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01527.x
更新日期:2007-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1999.tb00021.x
更新日期:1999-03-01 00:00:00
abstract::Charcot-Marie-Tooth disease (CMT) has been classified into two types: demyelinating forms (CMT1) and axonal forms (CMT2). Mutations in the CMT2A locus have been linked to the KIF1B and the mitofusin 2 (MFN2) genes. Here, we report a German patient with CMT2 with an underlying spontaneous mutation (c.281G-->A) in the M...
journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1999-03-01 00:00:00