Overactive bladder in Parkinson's disease: alteration of brainstem raphe detected by transcranial sonography.

Abstract:

:Urinary dysfunction is very common in idiopathic Parkinson's disease (PD) and manifests primarily with symptoms of overactive bladder (OAB). Affection of central serotonergic systems has been suggested to play a role in OAB. The objective of this study was to evaluate whether in PD patients with OAB symptoms a specific alteration of the brainstem raphe (BR), which contains serotonergic neurons, can be detected with transcranial sonography (TCS). Of 116 PD patients enrolled, 19 had PD-related OAB symptoms (OAB+) unlike remaining 97 patients (OAB-). Patients were examined by a sonographer blinded to the clinical data. Reduced echogenicity of BR was found in 12 (63%) OAB+ patients but only in 18 (19%) of 93 assessable OAB- patients (Mann-Whitney U-test, P < 0.001). In OAB+ patients, lower raphe echogenicity score was associated with longer duration of OAB symptoms (anova, P = 0.033). Other TCS findings such as echogenicity of substantia nigra, thalami, lenticular and caudate nuclei, and widths of third and lateral ventricles did not differ between OAB+ and OAB- patients. TCS findings suggest a pathogenetic role of BR in OAB related to PD. Alterations may reflect disturbance of its central serotonergic system.

journal_name

Eur J Neurol

authors

Walter U,Dressler D,Wolters A,Wittstock M,Benecke R

doi

10.1111/j.1468-1331.2006.01463.x

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1291-7

issue

12

eissn

1351-5101

issn

1468-1331

pii

ENE1463

journal_volume

13

pub_type

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