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Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease.

Abstract：

BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenosis (LIAS), because small vessel is more associated with microcirculatory function. To assess microcirculatory integrity of stroke patients, we performed a functional transcranial Doppler test using a standardized visual stimulation test. METHODS:The neurovascular coupling was measured in the asymptomatic occipital cortex in ischaemic stroke patients with LIAS, SVD, and healthy elder controls. Bilateral posterior cerebral arteries were monitored to measure evoked flow velocity during resting and visual stimulation phase. Peak systolic flow velocity responses were recorded, and time course of hemodynamic response was modeled according to a control system analysis with the parameters gain, natural angular frequency, attenuation, and rate time. RESULTS:Reproduced for both sides, the functionally induced flow velocity changes (gain) were significantly lower in LIAS and SVD compared with controls (P < 0.001). Reductions in both stroke groups were in the same order. Neurovascular coupling in LIAS group did not show difference at the side of vessel stenosis compared with non-stenosis side or at different stenotic degrees. CONCLUSIONS:Interestingly, both LIAS and SVD showed an uncoupling of the blood supply of active neurons. This points to an additional small vessel dysfunction in patients with LIAS.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

doi

10.1111/j.1468-1331.2010.03262.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

731-6

issue

5

eissn

1351-5101

issn

1468-1331

journal_volume

18

pub_type

杂志文章

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