The impact of type 2 diabetes and body mass index on cerebral structure is modulated by brain reserve.

abstract：:Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial...

journal_title：European journal of neurology

authors： Stefan H,Steinhoff BJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Apathy is a frequent disturbance in stroke patients. The aim of this case-control study was to elucidate whether apathy: (i) was secondary to stroke or related to hospitalization, (ii) was related to thalamic and striatocapsular stroke lesions, (iii) was independent from cognitive impairment and ...

journal_title：European journal of neurology

authors： Caeiro L,Ferro JM,Figueira ML

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course ...

journal_title：European journal of neurology

authors： Ramagopalan SV,Byrnes JK,Orton SM,Dyment DA,Guimond C,Yee IM,Ebers GC,Sadovnick AD

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...

journal_title：European journal of neurology

authors： Bianchi M,Cosseddu M,Cotelli M,Manenti R,Brambilla M,Rizzetti MC,Padovani A,Borroni B

更新日期：2015-09-01 00:00:00

abstract：:A 45 year-old man presented with a rapid onset of memory impairment Brain computed tomography showed multiple abnormal low density areas in the deep cerebral white matter. Magnetic resonance imaging revealed bilateral thalamic infarcts and extensive thrombosis of the vein of Galen and the straight sinus, which was con...

journal_title：European journal of neurology

authors： Daif AK,Awada A,Rajeh SA,Andeejani A

更新日期：1995-11-01 00:00:00

abstract：:We evaluated the cerebral hemodynamic features of severe bilateral carotid stenosis by assessing and comparing cerebral vasomotor reactivity (VMR) in the middle cerebral (MCA) and vertebral arteries (VA) by transcranial Doppler and the Diamox (1 g acetazolamide i.v.) test. VMR was evaluated by recording the percentage...

journal_title：European journal of neurology

authors： Gur AY,Bornstein NM

更新日期：2006-02-01 00:00:00

abstract：:The levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1) were measured in the red blood cells (RBC) of 34 patients with acute ischemic hemispheric stroke on the first and seventh day after their stroke onset, and compared with 30 control individuals matched for sex, age and...

journal_title：European journal of neurology

authors： Demirkaya S,Topcuoglu MA,Aydin A,Ulas UH,Isimer AI,Vural O

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mutations in the PLA2G6 gene are causative of PLA2G6-associated neurodegeneration (PLAN), a spectrum of neurodegenerative conditions including infantile, childhood and adult onset forms. METHODS:Seventeen North African patients with a clinical suspicion of infantile-onset PLAN underwent clinical...

journal_title：European journal of neurology

authors： Romani M,Kraoua I,Micalizzi A,Klaa H,Benrhouma H,Drissi C,Turki I,Castellana S,Mazza T,Valente EM,Gouider-Khouja N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Conversion disorder (CD), or functional neurological disorder, is manifested as a neurological disturbance that is not macroscopically visible on clinical structural neuroimaging and is instead ascribed to underlying psychological stress. Known for many years in neuropsychiatry, a comprehensive e...

journal_title：European journal of neurology

authors： Monsa R,Peer M,Arzy S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ataxia-telangiectasia (A-T) is a rare neurodegenerative disease, due to A-T mutated (ATM) gene mutations, which typically presents with signs of progressive neurological dysfunction, cerebellar ataxia and uncoordinated movements. A-T severely affects patients' quality of life. Successful treatmen...

journal_title：European journal of neurology

authors： Cirillo E,Del Giudice E,Micheli R,Cappellari AM,Soresina A,Dellepiane RM,Pietrogrande MC,Dell'Era L,Specchia F,Pession A,Plebani A,Pignata C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Depigmentation of the substantia nigra (SN) and locus coeruleus (LC) is a conspicuous pathological feature of Parkinson's disease (PD) and is related to the loss of neuromelanin, whose paramagnetic properties result in high signal on specific T1-weighted magnetic resonance imaging (MRI). Recent studies have ...

journal_title：European journal of neurology

authors： Reimão S,Pita Lobo P,Neutel D,Correia Guedes L,Coelho M,Rosa MM,Ferreira J,Abreu D,Gonçalves N,Morgado C,Nunes RG,Campos J,Ferreira JJ

更新日期：2015-03-01 00:00:00

abstract：:The genetic underpinnings of frontotemporal dementia (FTD), a rare yet early onset disorder still remains elusive. As FTD is characterized by a serotonergic deficit in the frontal lobe, and as some symptoms of FTD resemble conditions of monoamino oxidase A (MAO-A) deficiency, MAO-A is an attractive candidate gene for ...

journal_title：European journal of neurology

authors： Reif A,Scarpini E,Venturelli E,Töpner T,Fenoglio C,Lesch KP,Galimberti D

更新日期：2008-06-01 00:00:00

abstract：:While optimal treatment strategies are widely established for daytime treatment of Parkinson's disease (PD), nighttime problems of PD are often not adequately addressed in clinical practice. Nocturnal/sleep disturbance is common in PD and occurs due to a combination of the disease process and effect of dopaminergic an...

journal_title：European journal of neurology

authors： Chaudhuri KR

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuromelanin of the brainstem, which is considered a marker of neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate the NM-MRI features of de novo PD and to determine whether these feat...

journal_title：European journal of neurology

authors： Wang J,Li Y,Huang Z,Wan W,Zhang Y,Wang C,Cheng X,Ye F,Liu K,Fei G,Zeng M,Jin L

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-...

journal_title：European journal of neurology

authors： Bluher A,Devan WJ,Holliday EG,Nalls M,Parolo S,Bione S,Giese AK,Boncoraglio GB,Maguire JM,Müller-Nurasyid M,Gieger C,Meschia JF,Rosand J,Rolfs A,Kittner SJ,Mitchell BD,O'Connell JR,Cheng YC

更新日期：2015-11-01 00:00:00

abstract：:Since the 1970s, intravenous (IV) phenytoin (PHT) has traditionally been used as second-stage treatment for convulsive status epilepticus (SE) after failure of benzodiazepines. The aim of this review was to critically assess the evidence supporting the use of IV PHT as treatment of convulsive SE in patients of any age...

journal_title：European journal of neurology

authors： Brigo F,Bragazzi NL,Lattanzi S,Nardone R,Trinka E

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calculation of the cerebrospinal fluid:serum glucose (CSF:SGlu ) ratio is part of the routine cerebrospinal fluid (CSF) work-up. Reference values have been defined for lumbar CSF, but are lacking for ventricular CSF. The objective of this study was to investigate whether the CSF:SGlu ratio is sim...

journal_title：European journal of neurology

authors： Hegen H,Walde J,Auer M,Deisenhammer F

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Dopamine is an important neurotransmitter in the regulation of the sleep-wake cycle, and parkinsonian patients suffer from prominent sleep abnormalities. Hence, the question arises whether the disrupted sleep pattern in Parkinson's disease (PD) is responsive to dopaminergic treatment. METHODS:Thirty-two pat...

journal_title：European journal of neurology

authors： Wailke S,Herzog J,Witt K,Deuschl G,Volkmann J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The known monogenic forms of stroke are rare. The aim of this study was to analyze pedigrees of young stroke patients regarding possible monogenic cerebrovascular disease and to evaluate the possibility of genetic stroke in these families. This may contribute to a better understanding of disease ...

journal_title：European journal of neurology

authors： Ilinca A,Kristoffersson U,Soller M,Lindgren AG

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The purpose of the study is to investigate the epidemiology and medical expenses of Wilson's disease in Taiwan. METHODS:Cases of Wilson's disease were identified from the National Health Insurance Research Database with corresponding International Classification of Diseases, Ninth Revision (ICD-9) code 275....

journal_title：European journal of neurology

authors： Lai CH,Tseng HF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Interferon beta (IFNbeta) preparations have some effect on the progressive phase of multiple sclerosis (MS). This limited effect might be partially because of a certain number of IFNbeta non-responders. Myxovirus resistance protein A (MxA)--a marker of IFNbeta bioactivity--was correlated with the...

journal_title：European journal of neurology

authors： Millonig A,Dressel A,Bahner D,Bitsch A,Bogumil T,Elitok E,Kitze B,Tumani H,Weber F,Gneiss C,Deisenhammer F

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fabry disease is an X-linked disease, and enzyme-based screening methods are not suitable for female patients. METHODS:In total, 1000 young stroke patients (18-55 years, 661 with ischaemic stroke and 339 with hypertensive intracerebral hemorrhage) were recruited. The Sequenom iPLEX assay was use...

journal_title：European journal of neurology

authors： Lee TH,Yang JT,Lee JD,Chang KC,Peng TI,Chang TY,Huang KL,Liu CH,Ryu SJ,Burlina AP

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Observational study to evaluate long-term effects of deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the ventral intermediate thalamic nucleus (VIM) on patients with medically refractory myoclonus dystonia (MD). BACKGROUND:More recently, pallidal as well as thalamic DBS have been appli...

journal_title：European journal of neurology

authors： Krause P,Koch K,Gruber D,Kupsch A,Gharabaghi A,Schneider GH,Kühn AA

更新日期：2021-01-16 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to examine the association amongst remote diffusion-weighted imaging lesions (R-DWILs), imaging markers of cerebral small vessel disease (cSVD) and total cSVD burden in patients with primary intracerebral haemorrhage (ICH). METHODS:In total, 344 consecutive primary ICH ...

journal_title：European journal of neurology

authors： Xu XH,Ye XH,Li JW,Cai JS,Gao T,Zhang WJ,Zhao GH,Tong LS,Gao F

更新日期：2019-07-01 00:00:00

abstract：:In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...

journal_title：European journal of neurology

authors： Tan EK

更新日期：2006-02-01 00:00:00

abstract：:Stroke is the second most common cause of mortality and a major cause of long-term disability of adults in most countries. This study was performed to determine the level of knowledge and awareness regarding risk factors and warning signs of stroke in a selected sample. This cross-sectional study was carried out in Ay...

journal_title：European journal of neurology

authors： Evci ED,Memis S,Ergin F,Beser E

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cranial nerve palsy is occasionally present in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), but its prevalence, characteristics and relations with the CIDP subtypes have rarely been investigated. The aim of this study was to systematically assess cranial nerve involveme...

journal_title：European journal of neurology

authors： Shibuya K,Tsuneyama A,Misawa S,Suichi T,Suzuki Y,Kojima Y,Nakamura K,Kano H,Prado M,Kuwabara S

更新日期：2020-12-01 00:00:00

abstract：:There is paucity of studies on predictors of long-term sequelae of tuberculous meningitis (TBM). We report the neurological sequelae of TBM at 1 year and their predictors. Patients with TBM who were followed up for 1 year were included. The diagnosis of TBM was based on clinical, cerebrospinal fluid (CSF) and computed...

journal_title：European journal of neurology

authors： Kalita J,Misra UK,Ranjan P

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Critical illness polyneuropathy and myopathy (CIP/CIM) is being increasingly recognized as a significant clinical problem in critically ill children especially if they have spent long periods in the intensive care unit. So the aim was to determine the frequency of CIP/CIM amongst mechanically ven...

journal_title：European journal of neurology

authors： Thabet Mahmoud A,Tawfik MAM,Abd El Naby SA,Abo El Fotoh WMM,Saleh NY,Abd El Hady NMS

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mutations in the glucocerebrosidase (GBA) gene have been implicated in the development of Parkinson's disease (PD). However, recent screenings for GBA mutations in PD subjects from different ethnic populations have yielded contradictory results. METHODS:We performed a case-control study to look ...

journal_title：European journal of neurology

authors： Hu FY,Xi J,Guo J,Yu LH,Liu L,He XH,Liu ZL,Zou XY,Xu YM

更新日期：2010-12-01 00:00:00