Abstract:
BACKGROUND AND PURPOSE:Interferon beta (IFNbeta) preparations have some effect on the progressive phase of multiple sclerosis (MS). This limited effect might be partially because of a certain number of IFNbeta non-responders. Myxovirus resistance protein A (MxA)--a marker of IFNbeta bioactivity--was correlated with the clinical response during an uncontrolled trial, investigating the safety of IFNbeta-1b in primary progressive (PPMS) patients. METHODS:Twenty PPMS were treated with IFNbeta-1b (s.c.) for 1 year. Blood samples were taken before and 1, 2, 3, 6, 9, 12, and 15 months after treatment initiation and MxA protein levels were measured. Patients were clinically evaluated by EDSS and the more sensitive Incapacity Status Scale (ISS) and stratified in a stable and a progressing group. RESULTS:Using ISS criteria, 11 patients remained stable and nine patients progressed during treatment. The mean area under the curve of log MxA levels during treatment were significantly higher in stable than in progressing patients (10.87 vs. 5.99; P = 0.002). CONCLUSION:A good biological response to IFNbeta might be associated with a better clinical effect of this drug and could be helpful in future clinical studies for early identification of treatment responders.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Millonig A,Dressel A,Bahner D,Bitsch A,Bogumil T,Elitok E,Kitze B,Tumani H,Weber F,Gneiss C,Deisenhammer Fdoi
10.1111/j.1468-1331.2008.02190.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
822-6issue
8eissn
1351-5101issn
1468-1331pii
ENE2190journal_volume
15pub_type
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