Clinical and genetic features of patients with amyotrophic lateral sclerosis in southern China.

abstract：BACKGROUND AND PURPOSE:Although erenumab has demonstrated significant reduction in migraine frequency and improved quality of life in studies lasting 3 to 12 months, little is known about long-term therapy. METHODS:This study was an open-label, 5-year treatment phase following a 12-week, double-blind, placebo-controll...

journal_title：European journal of neurology

authors： Ashina M,Goadsby PJ,Reuter U,Silberstein S,Dodick DW,Xue F,Zhang F,Paiva da Silva Lima G,Cheng S,Mikol DD

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND AND PURPOSE:Since the outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several reports indicated neurological involvement in COVID-19 disease. Muscle involvement has also been reported as evidenced by creatine kinase (CK) elevations and reports of myalgia. METHODS:Creat...

journal_title：European journal of neurology

authors： Pitscheider L,Karolyi M,Burkert FR,Helbok R,Wanschitz JV,Horlings C,Pawelka E,Omid S,Traugott M,Seitz T,Zoufaly A,Lindeck-Pozza E,Wöll E,Beer R,Seiwald S,Bellmann-Weiler R,Hegen H,Löscher WN

更新日期：2020-09-30 00:00:00

abstract：:We examined the peripheral-central sensory conduction by using somatosensory evoked potential (SEP) in a 48 year old diabetic patient with acute painful neuropathy. The sural, ulnar and median sensory nerve conduction and SEP elicited by wrist stimulation showed no abnormalities, nevertheless, the tibial nerve SEP rev...

journal_title：European journal of neurology

authors： Shimamura H,Baba M,Ozaki I,Matsunaga M,Onuma T

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuromelanin of the brainstem, which is considered a marker of neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate the NM-MRI features of de novo PD and to determine whether these feat...

journal_title：European journal of neurology

authors： Wang J,Li Y,Huang Z,Wan W,Zhang Y,Wang C,Cheng X,Ye F,Liu K,Fei G,Zeng M,Jin L

更新日期：2018-07-01 00:00:00

abstract：:It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy-two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disabi...

journal_title：European journal of neurology

authors： De Reuck J,Claeys I,Martens S,Vanwalleghem P,Van Maele G,Phlypo R,Hallez H

更新日期：2006-04-01 00:00:00

abstract：:A comprehensive battery of neuropsychological tests sampling a wide range of cognitive functions was administrated to 36 patients with systemic lupus erythematosus (SLE), and a control group consisting of 31 patients with persistent symptoms after whiplash injury. Our results demonstrated significant group differences...

journal_title：European journal of neurology

authors： Waterloo K,Omdal R,Mellgren SI,Husby G

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuropsychiatric symptoms are commonly observed in neurodegenerative diseases. No biomarker is currently available to diagnose psychiatric conditions. As a consequence, the distinction between psychiatric and neurodegenerative disorders can be challenging in daily practice. METHODS:This retrospe...

journal_title：European journal of neurology

authors： Fourier A,Formaglio M,Kaczorowski F,Mollion H,Perret-Liaudet A,Sauvee M,Quadrio I

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease...

journal_title：European journal of neurology

authors： Kim YJ,Kwon HK,Lee JM,Kim YJ,Kim HJ,Jung NY,Kim ST,Lee KH,Na DL,Seo SW

更新日期：2015-04-01 00:00:00

abstract：:The purpose of these experiments was to compare the spread of three formulations of botulinum neurotoxin A. A gelatin/phosphate buffer (C), DysportR (D {0.5 U}, BotoxR (B {0.167 U}), or a purified preparation of botulinum neurotoxin A [Bont A] (BA {0.5 U}) was injected into the tibialis anterior of male, Wistar rats. ...

journal_title：European journal of neurology

authors： Dodd SL,Rowell BA,Vrabas IS,Arrowsmith RJ,Weatherill PJ

更新日期：1998-03-01 00:00:00

abstract：:The objective of this study was to investigate the efficacy, safety and tolerability of triptans in patients who suffer from familial or sporadic hemiplegic migraine. Seventy-six subjects had used triptans at least once as an abortive treatment. Average triptan response was 6.9 (SD +/-3.1) and adverse event severity 4...

journal_title：European journal of neurology

authors： Artto V,Nissilä M,Wessman M,Palotie A,Färkkilä M,Kallela M

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Data on the role of endogenous sex steroids in cerebrovascular disease are sparse. Estradiol is a hormone with diverse actions on the central nervous system. Our aim was to investigate the role of circulating estradiol levels in a postmenopausal acute stroke population. METHODS:During a time-period of 2 yea...

journal_title：European journal of neurology

authors： Pappa T,Vemmos K,Mantzou E,Savvari P,Stamatelopoulos K,Alevizaki M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), ...

journal_title：European journal of neurology

authors： Toscano M,Viganò A,Rea A,Verzina A,Sasso D'Elia T,Puledda F,Longo L,Mancini V,Ruggiero M,Jannini TB,Giuliani G,Albino F,Altieri M,Vicenzini E,Fattapposta F,Pauri F,Giacomini P,Ruoppolo G,Di Piero V

更新日期：2019-04-01 00:00:00

abstract：:This report discusses a biopsy proven case of cerebral amyloid angiopathy, with additional prominent vascular inflammatory features, characterized by a rapidly progressive dementia and leukoencephalopathy, where the clinical and radiological abnormalities resolved rapidly with minimal therapeutic intervention. We prop...

journal_title：European journal of neurology

authors： Harkness KA,Coles A,Pohl U,Xuereb JH,Baron JC,Lennox GG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischaemic stroke frequently has a cardioembolic (CE) source. Clinical and echocardiographic parameters associated with CE stroke were evaluated. METHODS:In all, 93 consecutive ischaemic stroke patients who underwent a transthoracic echocardiogram were retrospectively analysed; strokes were class...

journal_title：European journal of neurology

authors： Ferkh A,Brown P,O'Keefe E,Zada M,Duggins A,Thiagalingam A,Altman M,Boyd A,Byth K,Kizana E,Denniss AR,Thomas L

更新日期：2019-10-01 00:00:00

abstract：:The majority of patients with multiple sclerosis (MS) experience gradual progression of disability, either as secondary progressive MS (SPMS) or primary progressive MS (PPMS). A subgroup with relapsing-remitting MS shows a benign course with little or no disease progression and minimal disability decades after the fir...

journal_title：European journal of neurology

authors： Ramsaransing GS,Heersema DJ,De Keyser J

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...

journal_title：European journal of neurology

authors： Andersen JB,Owe JF,Engeland A,Gilhus NE

更新日期：2014-07-01 00:00:00

abstract：:We describe a patient who, three years after the onset of an olivopontocerebellar atrophy, developed a right cerebral tumour. The cerebellar symptomatology also included, as in other cerebellar patients previously described, a peripheral dysgraphia. Because this deficit of writing is generally reported in patients wit...

journal_title：European journal of neurology

authors： Silveri MC,Misciagna S,Laudisio A,Colosimo C

更新日期：2000-05-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) has been classified into two types: demyelinating forms (CMT1) and axonal forms (CMT2). Mutations in the CMT2A locus have been linked to the KIF1B and the mitofusin 2 (MFN2) genes. Here, we report a German patient with CMT2 with an underlying spontaneous mutation (c.281G-->A) in the M...

journal_title：European journal of neurology

authors： Neusch C,Senderek J,Eggermann T,Elolff E,Bähr M,Schneider-Gold C

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Dopamine is an important neurotransmitter in the regulation of the sleep-wake cycle, and parkinsonian patients suffer from prominent sleep abnormalities. Hence, the question arises whether the disrupted sleep pattern in Parkinson's disease (PD) is responsive to dopaminergic treatment. METHODS:Thirty-two pat...

journal_title：European journal of neurology

authors： Wailke S,Herzog J,Witt K,Deuschl G,Volkmann J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The 'hot cross bun' sign (HCBS), typically seen in the patients with multiple system atrophy, refers to a cruciform hyperintensity in the pons on T2-weighted MRI. Little is known about its pathological basis and prevalence in other degenerative cerebellar diseases and healthy population. We inves...

journal_title：European journal of neurology

authors： Lee YC,Liu CS,Wu HM,Wang PS,Chang MH,Soong BW

更新日期：2009-04-01 00:00:00

abstract：:The activities of the metalloproteinase gelatinase B, and the presence of IL-6, an inducer of metalloproteinase inhibitors, were investigated in CSF samples of 190 patients with multiple sclerosis (MS; n = 55), optic neuritis (ON; n = 46), other inflammatory neurological diseases (OIND; n = 27) or control patients (CO...

journal_title：European journal of neurology

authors： Paemen L,Olsson T,Söderström M,van Damme J,Opdenakker G

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disease. In addition to the traditional clinical triad, there is also a diversity of clinical signs, and it may be related to other systemic diseases. METHODS:In the present study, we report a case of MRS with endocrine disorders ...

journal_title：European journal of neurology

authors： Wang S,Wang H,Shi X,Wu F,Lv L,Hu M,Sun W,Wu L,Zhou H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND AND PURPOSE:In contrast to anterior circulation stroke (ACS), there is no evidence from randomized trials that mechanical thrombectomy (MT) with modern stent retrievers or thromboaspiration is safe and effective in posterior circulation stroke (PCS). METHODS:The present analysis was based on the prospective...

journal_title：European journal of neurology

authors： Weber R,Minnerup J,Nordmeyer H,Eyding J,Krogias C,Hadisurya J,Berger K,REVASK investigators.

更新日期：2019-02-01 00:00:00

abstract：:In the present study we have explored antigliadin (AGA) and antireticulin (ARA) antibody tests for the serological screening for coeliac disease (CD) of 206 children with neurological disorders. IgA- or/and IgG-type AGA was discovered in 17 (8.3%) patients and IgA-type ARA in one (0.5%) patient. A small intestinal bio...

journal_title：European journal of neurology

authors： Salur L,Uibo O,Talvik I,Justus I,Metsküla K,Talvik T,Uibo R

更新日期：2000-11-01 00:00:00

abstract：:Myelitis is one of the most severe central nervous system complications seen in association with Mycoplasma pneumoniae infections and both acute transverse myelitis (ATM) as well as acute disseminated encephalomyelitis (ADEM) have been observed. We reviewed all available literature on cases of Mycoplasma spp. associat...

journal_title：European journal of neurology

authors： Tsiodras S,Kelesidis T,Kelesidis I,Voumbourakis K,Giamarellou H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS....

journal_title：European journal of neurology

authors： Jawaid A,Salamone AR,Strutt AM,Murthy SB,Wheaton M,McDowell EJ,Simpson E,Appel SH,York MK,Schulz PE

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Patients with Parkinson's disease (PD) and chronically treated with L-DOPA exhibit, in a percentage of 10-30%, supra-physiological levels of plasma total homocysteinemia (tHcy). In this study, we have investigated, in a group of hyper-homocysteinemic PD patients, the time of hyper-tHcy recurrence after disco...

journal_title：European journal of neurology

authors： Belcastro V,Pierguidi L,Castrioto A,Menichetti C,Gorgone G,Ientile R,Pisani F,Rossi A,Calabresi P,Tambasco N

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN-β) efficacy could be mediated also by an increase of IGF-1 levels. A 2-year longitudinal study was performed to estimate the prevalence ...

journal_title：European journal of neurology

authors： Lanzillo R,Di Somma C,Quarantelli M,Carotenuto A,Pivonello C,Moccia M,Cianflone A,Marsili A,Puorro G,Saccà F,Russo CV,De Luca Picione C,Ausiello F,Colao A,Brescia Morra V

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clinical outcomes vary substantially among individuals with large vessel occlusion (LVO) stroke. A small infarct core and large imaging mismatch were found to be associated with good recovery. The aim of this study was to investigate whether those imaging variables would improve individual predic...

journal_title：European journal of neurology

authors： Hamann J,Herzog L,Wehrli C,Dobrocky T,Bink A,Piccirelli M,Panos L,Kaesmacher J,Fischer U,Stippich C,Luft AR,Gralla J,Arnold M,Wiest R,Sick B,Wegener S

更新日期：2020-11-21 00:00:00

abstract：BACKGROUND:Motor symptoms form the hallmark of Parkinson's Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery-Asberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of t...

journal_title：European journal of neurology

authors： Koerts J,Leenders KL,Koning M,Bouma A,van Beilen M

更新日期：2008-05-01 00:00:00