Abstract:
BACKGROUND AND PURPOSE:Blood pressure (BP) levels in acute intracerebral hemorrhage (ICH) and mortality have not been thoroughly studied in the young. METHODS:The relationship between BP and mortality was assessed in consecutive patients with first-ever, non-traumatic acute ICH at ≤50 years of age, enrolled in the Helsinki ICH Young Study. BP parameters included systolic BP (SBP), diastolic BP (DBP), mean arterial pressure and pulse pressure (SBP - DBP) at admission and 24 h, and delta (admission-24 h) BP parameters. Outcome measures were 3-month and long-term mortalities, adjusted for demographics and ICH score parameters for short-term and cardiovascular risk factors for long-term prognostics. Cox regression models were used to assess independent BP parameters associated with mortality. RESULTS:Of our 334 patients (61% male), 92 (27%) had pre-stroke hypertension and 54 (16%) used antihypertensive treatment. The follow-up extended to 17 years with a median of 12 (interquartile range, 9.65-14.7) years. Both 3-month (n = 56; 16%) and long-term (n = 97; 29%) mortalities were associated with significantly higher admission SBP and mean arterial pressure levels, but not with 24-h BP levels, compared with survivors. Patients with SBP ≥ 160 mmHg (n = 156; 46%) had a significantly higher mortality rate (n = 59, 17% vs. n = 38, 11%; P = 0.001) and died earlier (9.6; 95% confidence interval, 2.9-12.9 years vs. 11.3; 95% confidence interval, 8.1-13.9 years; P = 0.001) within the follow-up period. In multivariable analyses, admission SBP ≥160 mmHg was independently associated with both 3-month (hazard ratio, 2.50; 95% confidence interval, 1.19-5.24; P < 0.05) and long-term (hazard ratio, 2.02; 95% confidence interval, 1.18-3.43; P < 0.01) mortalities. CONCLUSIONS:In young patients with ICH, acute-phase SBP levels ≥160 mmHg are independently associated with increased mortality.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Mustanoja S,Putaala J,Koivunen RJ,Surakka I,Tatlisumak Tdoi
10.1111/ene.13662subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1034-1040issue
8eissn
1351-5101issn
1468-1331journal_volume
25pub_type
杂志文章abstract:INTRODUCTION:An association between parental smoking and multiple sclerosis (MS) in offspring has been reported. This study examined whether maternal smoking during pregnancy is associated with MS in offspring. METHODS:Swedish general population registers provided prospectively recorded information on maternal smoking...
journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
abstract::Registration of all hospitalized stroke patients is practiced in Sweden in order to assess care quality. Data in this register, Riks-Stroke (RS), may be biased due to incomplete registration. The purpose of this paper was to report changes in stroke outcome in relation to fluctuations in registration. Patients registe...
journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02311.x
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journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.2006.01616.x
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1331.2004.01019.x
更新日期:2005-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00071.x
更新日期:2000-05-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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pub_type: 杂志文章,多中心研究
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