Abstract:
BACKGROUND AND PURPOSE:Chronic syphilitic infection may lead to dementia. It is in general paresis (GP), which is the major late form of neurosyphilis, that cognitive impairment frequently occurs. The association between lipid metabolism and GP is unclear. METHODS:In this study, serum lipids were studied in 188 GP patients, in 241 syphilitic patients without neurosyphilis and in 539 healthy controls. The Mini-Mental State Examination (MMSE) was tested in all GP patients. Thirty-five GP patients had a follow-up evaluation 3 months after penicillin treatment. RESULTS:Significantly lower apolipoprotein A-I (apoA-I) levels were found in GP and in syphilitic patients without neurosyphilis compared to controls. In the 25-44-year-old groups, the male syphilitic patients without neurosyphilis had lower serum apoA-I levels and higher apolipoprotein B (apoB)/apoA-I ratios compared with female patients. A follow-up evaluation of 35 GP patients 3 months after penicillin treatment showed a significant positive correlation between increased apoA-I levels and MMSE scores. CONCLUSION:Abnormal apoA-I metabolism may be associated with the decline of cognitive performance. Long-term decrease of apoA-I level and higher apoB/apoA-I ratio may be contributing factors in syphilitic dementia. These results suggest a similar overlap between syphilitic dementia and lipid metabolism to that occurring in Alzheimer's disease.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Jiang Y,Zhang YF,Liu M,Ma LL,Peng FH,Huang QL,Ma XM,Chen XHdoi
10.1111/ene.13074subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1541-7issue
10eissn
1351-5101issn
1468-1331journal_volume
23pub_type
杂志文章abstract::Since the 1970s, intravenous (IV) phenytoin (PHT) has traditionally been used as second-stage treatment for convulsive status epilepticus (SE) after failure of benzodiazepines. The aim of this review was to critically assess the evidence supporting the use of IV PHT as treatment of convulsive SE in patients of any age...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.13560
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:Behçet's disease (BD) is a multisystemic, recurrent, inflammatory disorder. Neurological involvement is well-known but cerebral vasculitis and ischaemic stroke are unusual. CASE DESCRIPTION:A 43-year-old male patient presented with acute left hemiparesis, he had recurrent oral aphthae and scrotal ulcerati...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1046/j.1468-1331.2001.00300.x
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Impaired cortical inhibiton and maladaptive cortical plasticity are functional hallmarks of sporadic focal dystonias. Whether or not these mechanisms translate to generalized dystonias and whether these features reflect state or trait characteristics are topics of research in hereditary dystonias. METHODS:W...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03054.x
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Certain miscellaneous idiopathic headache disorders, which are regarded as entities, are grouped in Chapter 4 of the International Classification of Headache Disorders. Recent epidemiological research suggests that these headache disorders are underdiagnosed. OBJECTIVES:To give expert recommenda...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2011.03389.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prevalence of essential tremor (ET), one of the most common movement disorders, has not been properly evaluated amongst heterogeneous population in India. METHODS:We conducted a cross-sectional epidemiological study on the prevalence of ET in a randomly stratified population in the metropolitan ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02589.x
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Portugal has been identified as one of the countries with a high prevalence of LRRK2-G2019S, considered to be the most frequent known cause of familial and sporadic Parkinson's disease (PD). The aim of this study was to evaluate the prevalence of PD in Portugal using a door-to-door methodology. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13273
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The coronavirus disease 2019 (COVID-19) pandemic challenges neurologists in counseling multiple sclerosis (MS) patients with respect to their risk for and by severe acute respiratory syndrome coronavirus 2 and in guiding disease-modifying treatment (DMT). The objective was to determine the freque...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14555
更新日期:2020-09-25 00:00:00
abstract::Levodopa-carbidopa (LD) in low dosages adequately controls symptoms in most patients with Parkinson's disease and delays the appearance of fluctuations and dyskinesias. It has been suggested that early combination therapy with bromocriptine and levodopa delays or prevents the onset of late treatment complication assoc...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.530255.x
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:An immune activation response resembling virus or type I interferon responses has been observed in untreated multiple sclerosis (MS), but its pathogenic significance is uncertain. We studied the relationship between a type I interferon-like response in untreated patients with MS and disease activity. METHODS...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03116.x
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Quantification of intraepidermal nerve fibers (IENFs) in skin biopsies is now the tool of choice to diagnose small fiber neuropathies. An adequate normative dataset, necessary to assess normality cutoffs, is available for brightfield microscopy but not for immunofluorescence. METHODS:Intraepider...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/ene.12842
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Brain death (BD) is the irreversible loss of all functions of the brain and brainstem. Spontaneous and reflex movements of the limbs have been described in this condition. However, facial myokymia (FM) in BD has not been previously reported. The origin of that motor phenomenon in alive patients is still unce...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00208.x
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In contrast to anterior circulation stroke (ACS), there is no evidence from randomized trials that mechanical thrombectomy (MT) with modern stent retrievers or thromboaspiration is safe and effective in posterior circulation stroke (PCS). METHODS:The present analysis was based on the prospective...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13809
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although cerebrovascular disorders are the main cause of epilepsia partialis continua (EPC) in adulthood, the frequency of EPC after stroke is unknown. The aim was to prospectively ascertain its frequency 1 year after an ischaemic stroke. METHODS:This was a prospective study of consecutive acute...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13310
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The known monogenic forms of stroke are rare. The aim of this study was to analyze pedigrees of young stroke patients regarding possible monogenic cerebrovascular disease and to evaluate the possibility of genetic stroke in these families. This may contribute to a better understanding of disease ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12881
更新日期:2016-02-01 00:00:00
abstract::Myeloproliferative disorders (MPD) are associated with an increased risk for thrombembolic events. In this study, we examined the prognostic value of transcranial Doppler (TCD) microemboli detection regarding clinical events and correlated TCD findings with results of blood cell counts and platelet flow cytometry to g...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01616.x
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Fabry disease is an X-linked disease, and enzyme-based screening methods are not suitable for female patients. METHODS:In total, 1000 young stroke patients (18-55 years, 661 with ischaemic stroke and 339 with hypertensive intracerebral hemorrhage) were recruited. The Sequenom iPLEX assay was use...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.13775
更新日期:2019-03-01 00:00:00
abstract::In recent years, evidence has emerged for a bidirectional relationship between sleep and neurological and psychiatric disorders. First, sleep-wake disorders (SWDs) are very common and may be the first/main manifestation of underlying neurological and psychiatric disorders. Secondly, SWDs may represent an independent r...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.12781
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12528
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Polymorphisms of the interleukin-1 (IL-1) gene family have been proposed as potential variants for different diseases including multiple sclerosis (MS). With respect to MS, IL-1 beta (-511 C/T; rs16944), IL-1 beta (+3954 C/T; rs1143634), IL-1 alpha (-889 C/T; rs1800587), IL-1 alpha (+4845 G/T; rs17561), and ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.02952.x
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Migraine is a complex and disabling neurological disorder, the exact neurological mechanisms of which remain unclear. The thalamus is considered to be the hub of the central processing and integration of nociceptive information, as well as the modulation of these processes. METHODS:A total of 48...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14411
更新日期:2020-11-01 00:00:00
abstract::In visual evoked potential studies, habituation during stimulus repetition with the same stimulus at a constant intensity has been found to be abnormal in migraineurs between attacks. The purpose of this study was to investigate habituation of somatosensory evoked potentials (SEPs) and the effects of migraine on them....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.00387.x
更新日期:2002-05-01 00:00:00
abstract::Progression of atherosclerosis at extracranial carotid and intracranial arteries in patients with ischemic heart disease (IHD) is not well defined. We carried out a 5-year longitudinal study with magnetic resonance angiography (MRA) of patients with IHD to assess the incidence of progression of atherosclerosis at extr...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00620.x
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Efficacy and safety data have not previously been compiled for intramuscular interferon beta-1a (IM IFNβ-1a) in patients with multiple sclerosis (MS) ≥ 50 years of age. We investigated the efficacy and safety of IM IFNβ-1a in patients segregated by 50 and 40 years of age in separate meta-analyses. METHODS:T...
journal_title:European journal of neurology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1468-1331.2011.03460.x
更新日期:2012-01-01 00:00:00
abstract:AIM:To investigate the corticomotor projection to the upper limb in children with hemiplegic cerebral palsy (CP) and the changes that occur with botulinum toxin (BTX)-A. METHODS:The study design is a pilot prospective randomized trial. Twenty-two children with hemiplegic CP aged 7 years to 13 years 11 months were recr...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1331.2008.02194.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Depigmentation of the substantia nigra (SN) and locus coeruleus (LC) is a conspicuous pathological feature of Parkinson's disease (PD) and is related to the loss of neuromelanin, whose paramagnetic properties result in high signal on specific T1-weighted magnetic resonance imaging (MRI). Recent studies have ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12613
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition. METHODS:A detailed analysis of the cognitive course of the two forms is presented, span...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12186
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Frontotemporal dementia (FTD) is a degenerative disorder characterized, in its frontal variant, by psychiatric onset, deficits in executive functions and sparing of memory and visuo-spatial abilities. Studies on visuo-spatial abilities in FTD and Alzheimer's disease (AD) have mainly focused on co...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02128.x
更新日期:2008-06-01 00:00:00
abstract::Population-based data on the incidence, aetiology, and mortality associated with status epilepticus (SE) are required to develop preventative strategies for SE. Through a systematic review, we aimed to assess the methodological quality as well as similarities, and differences between available population based studies...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2004.00943.x
更新日期:2004-12-01 00:00:00
abstract::A 45 year-old man presented with a rapid onset of memory impairment Brain computed tomography showed multiple abnormal low density areas in the deep cerebral white matter. Magnetic resonance imaging revealed bilateral thalamic infarcts and extensive thrombosis of the vein of Galen and the straight sinus, which was con...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1995.tb00160.x
更新日期:1995-11-01 00:00:00
abstract::We describe a patient who, three years after the onset of an olivopontocerebellar atrophy, developed a right cerebral tumour. The cerebellar symptomatology also included, as in other cerebellar patients previously described, a peripheral dysgraphia. Because this deficit of writing is generally reported in patients wit...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00071.x
更新日期:2000-05-01 00:00:00