当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NEUROLOGY期刊下所有文献 > Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response.

Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response.

Abstract：

BACKGROUND:  Therapy for multiple sclerosis (MS) has a partial efficacy, and a significant proportion of treated patients will develop a suboptimal response with first-line disease-modifying drugs (DMD). Therapy switch in patients with MS can be a strategy after a treatment failure. We studied the change in clinical activity after switching of first-line DMD because of a treatment failure. METHODS:  Relapsing-remitting multiple sclerosis (RRMS) patients treated with interferon-beta (IFNB) or glatiramer acetate (GA) were divided into (i) patients without change in DMD, (ii) patients with a change in DMD because of a poor response, and (iii) those with a change in DMD without relation with response. Annualized relapse rate (ARR) and relapse-free proportions were analyzed. RESULTS:  We identified 923 patients with RRMS. Of the 180 who experienced a change because of suboptimal response, 90 switched to another first-line DMT, 38 to mitoxantrone, and 52 to natalizumab. Median ARR in the pre-DMD period on first DMD and second DMD was the following: 1, 1, and 0 for switchers from IFNB to another IFNB (P = 0.0001); 0.67, 1, and 0 for switchers from GA to IFNB (P = 0.01); 1, 1, and 0 for switchers from an IFNB to GA (P = 0.02); 1.1, 1.5, 0.2 for switchers from IFNB or GA to mitoxantrone (P = 0.0001); 0.9, 1, 0 for switchers from IFNB or GA to natalizumab (P = 0.0001). CONCLUSIONS:  In patients with RRMS who have a poor response, switch to another DMD may reduce the clinical activity of the disease.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Río J,Tintoré M,Sastre-Garriga J,Nos C,Castilló J,Tur C,Comabella M,Montalban X

doi

10.1111/j.1468-1331.2011.03648.x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

899-904

issue

6

eissn

1351-5101

issn

1468-1331

journal_volume

19

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF NEUROLOGY文献大全
  • Cerebral blood flow velocity changes during meaningful and meaningless gestures--a functional transcranial Doppler study.

    abstract：:The aim of the study was to use functional transcranial Doppler to investigate the possibility of revealing different activation patterns during healthy subjects' performance of meaningful and meaningless actions. Mean flow velocity (MFV) changes were recorded in middle cerebral arteries (MCAs) of 26 normal subjects d...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2006.01219.x

    authors： Matteis M,Federico F,Troisi E,Pasqualetti P,Vernieri F,Caltagirone C,Petrosini L,Silvestrini M

    更新日期：2006-01-01 00:00:00

  • Correlation of the patient's reported outcome Inflammatory-RODS with an objective metric in immune-mediated neuropathies.

    abstract：BACKGROUND AND PURPOSE:There is increasing interest in using patient-reported outcome measures (PROMs) in clinical studies to capture individual changes over time. However, PROMs have also been criticized because they are entirely subjective. Our objective was to examine the relationship between a subjective PROM and a...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13025

    authors： Draak TH,Gorson KC,Vanhoutte EK,van Nes SI,van Doorn PA,Cornblath DR,van den Berg LH,Faber CG,Merkies IS,PeriNomS Study Group.

    更新日期：2016-07-01 00:00:00

  • Urinary incontinence in multiple sclerosis: prevalence, severity and impact on patients' quality of life.

    abstract：BACKGROUND AND PURPOSE:Lower urinary tract symptoms (LUTS) including frequent urination, nocturia and urge urinary incontinence negatively impact quality of life. This project aimed at characterizing the prevalence and severity of urinary incontinence in multiple sclerosis (MS) patients and its association with demogra...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13010

    authors： Zecca C,Riccitelli GC,Disanto G,Singh A,Digesu GA,Panicari L,Puccini F,Mattioli M,Tubaro A,Gobbi C

    更新日期：2016-07-01 00:00:00

  • Exploding Head Syndrome (a.k.a. Episodic Cranial Sensory Shock) responds to single-pulse TMS.

    abstract：:We here present the case of a patient with a sleep disturbance attributed to the exploding head syndrome, recently redefined as 'episodic cranial sensory shock'. The patient, who suffered with concomitant migraine, was treated for headache prevention with daily single-pulse transcranial magnetic stimulation. Following...

    journal_title：European journal of neurology

    pub_type：

    doi：10.1111/ene.14747

    authors： Puledda F,Moreno-Ajona D,Goadsby PJ

    更新日期：2021-01-18 00:00:00

  • Lesions to the posterior insular cortex cause dysarthria.

    abstract：BACKGROUND:Up to now, there are few systematic studies in a sufficient number of patients with lesions involving the insular cortex (IC) examining whether damage of the IC is directly related to dysarthria. Thus, this is the first study applying modern voxel-lesion behaviour mapping (VLBM) aimed to examine whether the ...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2011.03473.x

    authors： Baier B,zu Eulenburg P,Glassl O,Dieterich M

    更新日期：2011-12-01 00:00:00

  • In-vivo signatures of neurodegeneration in isolated rapid eye movement sleep behaviour disorder.

    abstract：BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14215

    authors： Carli G,Caminiti SP,Galbiati A,Marelli S,Casoni F,Padovani A,Ferini-Strambi L,Perani D

    更新日期：2020-07-01 00:00:00

  • Cognitive frailty and falls in Chinese elderly people: a population-based longitudinal study.

    abstract：BACKGROUND AND PURPOSE:Falling is considered an important public health problem among older people. A recent cross-sectional study suggested that cognitive frailty (CF) is associated with falls. We aimed to explore whether CF is a risk factor for falls in a population-based longitudinal study. METHODS:Using data from ...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14572

    authors： Ma Y,Li X,Pan Y,Zhao R,Wang X,Jiang X,Li S

    更新日期：2021-02-01 00:00:00

  • Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis.

    abstract：:To determine whether eosinophils play a critical role in muscle fiber damage in patients with eosinophilic myositis (EM). We investigated expression of eosinophilic major basic protein (MBP) and interleukin (IL)-5 at the protein and mRNA levels in muscle biopsies from three patients with idiopathic EM. MBP deposits we...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1046/j.1468-1331.2003.00481.x

    authors： Murata K,Sugie K,Takamure M,Fujimoto T,Ueno S

    更新日期：2003-01-01 00:00:00

  • Impact of seizures on morbidity and mortality after stroke: a Canadian multi-centre cohort study.

    abstract：INTRODUCTION:Limited information is available about the impact of seizures on stroke outcome, health care delivery and resource utilization. OBJECTIVE:To determine whether the presence of seizures after stroke increases disability, mortality and health care utilization (length of hospital stay, ICU admission, consults...

    journal_title：European journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1468-1331.2009.02739.x

    authors： Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

    更新日期：2010-01-01 00:00:00

  • Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits. Data from the Italian CIDP Database.

    abstract：BACKGROUND AND PURPOSE:The role of lifestyle and dietary habits and antecedent events has not been clearly identified in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). METHODS:Information was collected about modifiable environmental factors and antecedent infections and vaccinations in patients with...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14044

    authors： Doneddu PE,Bianchi E,Cocito D,Manganelli F,Fazio R,Filosto M,Mazzeo A,Cosentino G,Cortese A,Jann S,Clerici AM,Antonini G,Siciliano G,Luigetti M,Marfia GA,Briani C,Lauria G,Rosso T,Cavaletti G,Carpo M,Benedetti L,

    更新日期：2020-01-01 00:00:00

  • Neurological and electrophysiological examinations on three groups of workers with different levels of exposure to mercury vapors.

    abstract：:The authors performed neurological, visual evoked potentials (VEP) and electroneurography (ENG) examinations on three groups of workers with occupational exposure to mercury vapors (Hg(0)), and on a control group. The exposure of dental professionals (n = 36) was mild, that of chloralkali plant workers (n = 36) was in...

    journal_title：European journal of neurology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1468-1331.1999.650571.x

    authors： Urban P,Lukás E,Nerudová J,Cábelková Z,Cikrt M

    更新日期：1999-09-01 00:00:00

  • COVID-19 pandemic and mental distress in multiple sclerosis: implications for clinical management.

    abstract：BACKGROUND AND PURPOSE:In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiat...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14580

    authors： Costabile T,Carotenuto A,Lavorgna L,Borriello G,Moiola L,Inglese M,Petruzzo M,Trojsi F,Ianniello A,Nozzolillo A,Cellerino M,Boffa G,Rosa L,Servillo G,Moccia M,Bonavita S,Filippi M,Lanzillo R,Brescia Morra V,Petracca

    更新日期：2020-10-11 00:00:00

  • Cerebral vasospasm in acute porphyria.

    abstract：BACKGROUND AND PURPOSE:Porphyrias are a group of inherited metabolic disorders resulting from a specific deficiency along the pathway of haem biosynthesis. A clinical classification distinguishes acute from non-acute porphyrias considering the occurrence of life-threatening neurovisceral attacks, presenting with abdomi...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13347

    authors： Olivier P,Van Melkebeke D,Honoré PJ,Defreyne L,Hemelsoet D

    更新日期：2017-09-01 00:00:00

  • Speed performance and long-term functional and vocational outcome in a group of young patients with moderate or severe traumatic brain injury.

    abstract：:We studied specific aspects of speed performance in neuropsychological tests and functional and vocational long-term outcome among moderate or severe traumatic brain injury (TBI) patients admitted to a rehabilitation programme. A group of 140 patients with mild, moderate or severe TBI was followed up for a minimum of ...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.1999.tb00011.x

    authors： Asikainen I,Nybo T,Muller K,Sarna S,Kaste M

    更新日期：1999-03-01 00:00:00

  • Serum uric acid levels correlate with benign paroxysmal positional vertigo.

    abstract：BACKGROUND AND PURPOSE:Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV. METHODS:Fifty patients with BPPV, and 40 age- and sex-matched co...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.12248

    authors： Celikbilek A,Gencer ZK,Saydam L,Zararsiz G,Tanik N,Ozkiris M

    更新日期：2014-01-01 00:00:00

  • Increased disease severity in non-Western immigrants with multiple sclerosis in Oslo, Norway.

    abstract：BACKGROUND AND PURPOSE:Non-Western immigrants to Norway acquire an increased risk of multiple sclerosis (MS) after migration. Ethnicity and the presence of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) might influence the disease course. The aim of this study was to investigate differences in disease severi...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.12227

    authors： Berg-Hansen P,Smestad C,Sandvik L,Harbo HF,Celius EG

    更新日期：2013-12-01 00:00:00

  • Long-term efficacy and safety of erenumab in migraine prevention: Results from a 5-year, open-label treatment phase of a randomized clinical trial.

    abstract：BACKGROUND AND PURPOSE:Although erenumab has demonstrated significant reduction in migraine frequency and improved quality of life in studies lasting 3 to 12 months, little is known about long-term therapy. METHODS:This study was an open-label, 5-year treatment phase following a 12-week, double-blind, placebo-controll...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.14715

    authors： Ashina M,Goadsby PJ,Reuter U,Silberstein S,Dodick DW,Xue F,Zhang F,Paiva da Silva Lima G,Cheng S,Mikol DD

    更新日期：2021-01-05 00:00:00

  • Prevalence of essential tremor in the city of Kolkata, India: a house-to-house survey.

    abstract：BACKGROUND AND PURPOSE:Prevalence of essential tremor (ET), one of the most common movement disorders, has not been properly evaluated amongst heterogeneous population in India. METHODS:We conducted a cross-sectional epidemiological study on the prevalence of ET in a randomly stratified population in the metropolitan ...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2009.02589.x

    authors： Das SK,Banerjee TK,Roy T,Raut DK,Chaudhuri A,Hazra A

    更新日期：2009-07-01 00:00:00

  • A clinical variance in familial amyotrophic lateral sclerosis with a point mutation in Cu/Zn superoxide dismutase gene.

    abstract：:We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). In this family, the age at onset was young (28.0 ± 3.8 years old, mean ± SD, n = 4) a...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.1995.tb00141.x

    authors： Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

    更新日期：1995-09-01 00:00:00

  • No difference in efficacy of two different doses of intravenous immunoglobulins in MS: clinical and MRI assessment.

    abstract：:We performed a double-blind, placebo-controlled study to evaluate the efficacy of low and high dose of intravenous immunoglobulins (IVIG) in relapsing/remitting (RR) multiple sclerosis (MS). Patients (n = 49) with clinical definite RR MS were randomly allocated to three groups and treated with 0.2 g/kg (n = 17) or 0.4...

    journal_title：European journal of neurology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1468-1331.2002.00500.x

    authors： Lewańska M,Siger-Zajdel M,Selmaj K

    更新日期：2002-11-01 00:00:00

  • The long-term functional status in patients with Guillain-Barré syndrome.

    abstract：BACKGROUND AND PURPOSE:The purpose of this study was to analyse the long-term impact of Guillain-Barré syndrome (GBS) on quality of life, and the relationship between clinical variables at disease onset and symptoms at follow-up to general health status. METHODS:Forty-two GBS patients were examined at median 6 years a...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2008.02311.x

    authors： Rudolph T,Larsen JP,Farbu E

    更新日期：2008-12-01 00:00:00

  • Stroke unit care in clinical practice: an observational study in the Florence center of the European Registers of Stroke (EROS) Project.

    abstract：BACKGROUND:Randomized trials and meta-analyses indicate positive effects of stroke unit (SU) care on survival and dependency of patients with stroke. However, data on the advantages of SU in 'real-world' settings are limited. We prospectively assessed, in a large University Hospital, the effect of SU versus other conve...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2010.03207.x

    authors： Di Carlo A,Lamassa M,Wellwood I,Bovis F,Baldereschi M,Nencini P,Poggesi A,Cramaro A,Pescini F,Lucente G,Wolfe CD,Inzitari D,European Registers of Stroke (EROS) Project.

    更新日期：2011-05-01 00:00:00

  • A case-control study of Guillain-Barré syndrome in Harbin, China.

    abstract：:We evaluated the putative factors for the onset of Guillain-Barré syndrome (GBS) in Harbin, China by a case-control study based on the information from GBS patients identified from a population-based incidence survey, which is the first study of this kind in China. Sixty-nine GBS patients were identified during a 1-ye...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2006.01390.x

    authors： Cheng Q,Wang DS,Jiang GX,Han H,Zhang Y,Wang WZ,Fredrikson S

    更新日期：2006-09-01 00:00:00

  • Rhabdomyolysis and fluctuating asymptomatic hyperCKemia associated with CACNA1S variant.

    abstract：BACKGROUND AND PURPOSE:CACNA1S encodes Cav 1.1, a voltage sensor for muscle excitation-contraction coupling, which activates the ryanodine receptor 1 (RYR1) leading to calcium release from the sarcoplasmic reticulum. CACNA1S mutations cause hypokalemic periodic paralysis, malignant hyperthermia and congenital myopathy....

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.13528

    authors： Anandan C,Cipriani MA,Laughlin RS,Niu Z,Milone M

    更新日期：2018-02-01 00:00:00

  • Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4-IgG versus MOG-IgG seropositive cases in the Netherlands.

    abstract：BACKGROUND AND PURPOSE:Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare inflammatory demyelinating disorders of the central nervous system. The identification of specific antibodies directed to aquaporin 4 (AQP4-IgG) led to the distinction from multiple sclerosis. However, up to 25% of the clinicall...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.12898

    authors： van Pelt ED,Wong YY,Ketelslegers IA,Hamann D,Hintzen RQ

    更新日期：2016-03-01 00:00:00

  • Botulinum toxin treatment of sialorrhea: comparing different therapeutic preparations.

    abstract：:In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...

    journal_title：European journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1468-1331.2006.01447.x

    authors： Tan EK

    更新日期：2006-02-01 00:00:00

  • Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis.

    abstract：:Therapy-induced binding and neutralizing antibodies is a major problem in interferon (IFN)-beta treatment of multiple sclerosis. The objective of this study was to provide guidelines outlining the methods and clinical use of the measurements of binding and neutralizing antibodies. Systematic search of the Medline data...

    journal_title：European journal of neurology

    pub_type： 杂志文章,实务指引,评审

    doi：10.1111/j.1468-1331.2005.01386.x

    authors： Sørensen PS,Deisenhammer F,Duda P,Hohlfeld R,Myhr KM,Palace J,Polman C,Pozzilli C,Ross C,EFNS Task Force on Anti-IFN-beta Antibodies in Multiple Sclerosis.

    更新日期：2005-11-01 00:00:00

  • Myasthenia and risk of cancer: a population-based case-control study.

    abstract：BACKGROUND AND PURPOSE:To evaluate the association between having non-thymoma myasthenia and the risk of extra-thymic cancer in a population-based setting. METHODS:A nationwide case-control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer du...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/ene.12383

    authors： Pedersen EG,Pottegård A,Hallas J,Friis S,Hansen K,Jensen PE,Gaist D

    更新日期：2014-05-01 00:00:00

  • Maternal smoking during pregnancy and multiple sclerosis amongst offspring.

    abstract：INTRODUCTION:An association between parental smoking and multiple sclerosis (MS) in offspring has been reported. This study examined whether maternal smoking during pregnancy is associated with MS in offspring. METHODS:Swedish general population registers provided prospectively recorded information on maternal smoking...

    journal_title：European journal of neurology

    pub_type： 杂志文章

    doi：10.1111/j.1468-1331.2008.02331.x

    authors： Montgomery SM,Bahmanyar S,Hillert J,Ekbom A,Olsson T

    更新日期：2008-12-01 00:00:00

  • EFNS guideline on the drug treatment of migraine - report of an EFNS task force.

    abstract：:Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....

    journal_title：European journal of neurology

    pub_type： 杂志文章,实务指引

    doi：10.1111/j.1468-1331.2006.01411.x

    authors： Members of the task force:.,Evers S,Afra J,Frese A,Goadsby PJ,Linde M,May A,Sándor PS

    更新日期：2006-06-01 00:00:00