Abstract:
:We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 +/- 0.25 vs. 1.05 +/- 0.39; P = 0.004), more pronounced in the putamen (0.61 +/- 0.24 vs. 0.85 +/- 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Canesi M,Benti R,Marotta G,Cilia R,Isaias IU,Gerundini P,Pezzoli G,Antonini Adoi
10.1111/j.1468-1331.2006.01642.xsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
297-9issue
3eissn
1351-5101issn
1468-1331pii
ENE1642journal_volume
14pub_type
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