Striatal dopamine transporter binding in patients with Parkinson's disease and severe occupational hydrocarbon exposure.

Abstract:

:We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 +/- 0.25 vs. 1.05 +/- 0.39; P = 0.004), more pronounced in the putamen (0.61 +/- 0.24 vs. 0.85 +/- 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.

journal_name

Eur J Neurol

authors

Canesi M,Benti R,Marotta G,Cilia R,Isaias IU,Gerundini P,Pezzoli G,Antonini A

doi

10.1111/j.1468-1331.2006.01642.x

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

297-9

issue

3

eissn

1351-5101

issn

1468-1331

pii

ENE1642

journal_volume

14

pub_type

杂志文章
  • Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.

    abstract::To evaluate prevalence of use and prescribing patterns of antiepileptic drugs (AEDs) in Italian general practice. Primary care data were obtained from the Health Search Database, a longitudinal observational database implemented by the Italian College of General Practitioners (GPs). We selected 465 061 subjects regist...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2007.01970.x

    authors: Savica R,Beghi E,Mazzaglia G,Innocenti F,Brignoli O,Cricelli C,Caputi AP,Musolino R,Spina E,Trifirò G

    更新日期:2007-12-01 00:00:00

  • Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A).

    abstract::Charcot-Marie-Tooth disease (CMT) has been classified into two types: demyelinating forms (CMT1) and axonal forms (CMT2). Mutations in the CMT2A locus have been linked to the KIF1B and the mitofusin 2 (MFN2) genes. Here, we report a German patient with CMT2 with an underlying spontaneous mutation (c.281G-->A) in the M...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01688.x

    authors: Neusch C,Senderek J,Eggermann T,Elolff E,Bähr M,Schneider-Gold C

    更新日期:2007-05-01 00:00:00

  • A clinical variance in familial amyotrophic lateral sclerosis with a point mutation in Cu/Zn superoxide dismutase gene.

    abstract::We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). In this family, the age at onset was young (28.0 ± 3.8 years old, mean ± SD, n = 4) a...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1995.tb00141.x

    authors: Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

    更新日期:1995-09-01 00:00:00

  • Long-term clinical experience with weekly interferon beta-1a in relapsing multiple sclerosis.

    abstract::Post-marketing surveillance studies are needed to assess the long-term safety, compliance and clinical efficacy of interferon beta-1a (IFNbeta-1a) therapy in multiple sclerosis (MS) patients. The goals of this study were to (i) assess the safety, compliance and clinical efficacy of long-term intramuscular (i.m.) IFNbe...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1468-1331.2006.01422.x

    authors: Coppola G,Lanzillo R,Florio C,Orefice G,Vivo P,Ascione S,Schiavone V,Pagano A,Vacca G,De Michele G,Morra VB

    更新日期:2006-09-01 00:00:00

  • N-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum bi...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12222

    authors: Purroy F,Suárez-Luis I,Mauri-Capdevila G,Cambray S,Farré J,Sanahuja J,Piñol-Ripoll G,Quílez A,González-Mingot C,Begué R,Gil MI,Fernández E,Benabdelhak I

    更新日期:2014-04-01 00:00:00

  • T-cell interleukin-6 receptor binding in interferon-beta-1b-treated multiple sclerosis patients.

    abstract::Multiple sclerosis (MS) is a T-cell-mediated autoimmune demyelinating disease of the central nervous system, associated with an altered cytokine network. We previously assayed peripheral blood T-lymphocyte binding for two prototypic cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and foun...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2000.00139.x

    authors: Bongioanni P,Lombardo F,Moscato G,Mosti S,Meucci G

    更新日期:2000-11-01 00:00:00

  • Ultrasound-guided lumbar puncture for nusinersen administration in spinal muscular atrophy patients.

    abstract:BACKGROUND AND PURPOSE:The purpose was to report the results of ultrasound-guided lumbar puncture for the administration of nusinersen in spinal muscular atrophy (SMA) patients with complex spines. METHODS:Eighteen SMA patients (five children, five adolescents and eight adults) with either severe scoliosis or spondylo...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14586

    authors: Veiga-Canuto D,Cifrián-Pérez M,Pitarch-Castellano I,Vázquez-Costa JF,Aparici F

    更新日期:2021-02-01 00:00:00

  • Parkinsonism and tardive antecollis in frontotemporal dementia--increased sensitivity to newer antipsychotics?

    abstract::Frontotemporal dementia (FTD) often presents with behavioural changes warranting treatment with antipsychotic medications. It is known that patients with Lewy body dementia are sensitive to developing extrapyramidal symptoms (EPS) from these medications. This has not been emphasized in FTD. We report three patients wi...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2007.02032.x

    authors: Czarnecki K,Kumar N,Josephs KA

    更新日期:2008-02-01 00:00:00

  • Peritumoral edema on MRI at initial diagnosis: an independent prognostic factor for glioblastoma?

    abstract:BACKGROUND:Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral edema as a prognostic factor is controversial. MATERIALS AND METHODS:This multi-centre clinical retrospective study included 110 patie...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02613.x

    authors: Schoenegger K,Oberndorfer S,Wuschitz B,Struhal W,Hainfellner J,Prayer D,Heinzl H,Lahrmann H,Marosi C,Grisold W

    更新日期:2009-07-01 00:00:00

  • Evaluation of health-related quality of life, fatigue and depression in neuromyelitis optica.

    abstract:BACKGROUND:The burden of multiple sclerosis (MS) includes fatigue, depression and worsening of health-related quality of life (HRQOL). These changes have not been yet measured in neuromyelitis optica (NMO). Our aim was to assess the HRQOL, fatigue and depression in NMO. METHODS:We administered French validated self-qu...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1468-1331.2010.03252.x

    authors: Chanson JB,Zéphir H,Collongues N,Outteryck O,Blanc F,Fleury M,Vermersch P,de Seze J

    更新日期:2011-06-01 00:00:00

  • Frequencies of falls and associated features at different stages of Parkinson's disease.

    abstract:BACKGROUND AND PURPOSE:To examine the frequencies and clinical characteristics of fallers and non-fallers at different stages of Parkinson's disease (PD). METHODS:The sample consisted of 232 patients in an unselected cross-sectional cohort of patients with PD, 207 newly diagnosed and drug naive patients and 175 contro...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2012.03821.x

    authors: Hiorth YH,Lode K,Larsen JP

    更新日期:2013-01-01 00:00:00

  • Association between seropositivity to Chlamydia pneumoniae and acute ischaemic stroke.

    abstract::Recent studies suggest an association between Chlamydia pneumoniae infection with atherosclerosis, including cerebrovascular disease. We investigated the prevalence of Chlamydial seropositivity in patients with acute ischaemic stroke syndrome compared with age- and sex-matched control subjects. Specific antibodies (Ig...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2002.00408.x

    authors: Madre JG,Garcia JL,Gonzalez RC,Montero JM,Paniagua EB,Escribano JR,Martinez JD,Cenjor RF

    更新日期:2002-05-01 00:00:00

  • Evolving atherosclerosis at carotid and intracranial arteries in Japanese patients with ischemic heart disease: a 5-year longitudinal study with MR angiography.

    abstract::Progression of atherosclerosis at extracranial carotid and intracranial arteries in patients with ischemic heart disease (IHD) is not well defined. We carried out a 5-year longitudinal study with magnetic resonance angiography (MRA) of patients with IHD to assess the incidence of progression of atherosclerosis at extr...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2003.00620.x

    authors: Uehara T,Tabuchi M,Mori E,Yamadori A

    更新日期:2003-09-01 00:00:00

  • The high frequency of coeliac disease among children with neurological disorders.

    abstract::In the present study we have explored antigliadin (AGA) and antireticulin (ARA) antibody tests for the serological screening for coeliac disease (CD) of 206 children with neurological disorders. IgA- or/and IgG-type AGA was discovered in 17 (8.3%) patients and IgA-type ARA in one (0.5%) patient. A small intestinal bio...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2000.00130.x

    authors: Salur L,Uibo O,Talvik I,Justus I,Metsküla K,Talvik T,Uibo R

    更新日期:2000-11-01 00:00:00

  • Epilepsia partialis continua after an anterior circulation ischaemic stroke.

    abstract:BACKGROUND AND PURPOSE:Although cerebrovascular disorders are the main cause of epilepsia partialis continua (EPC) in adulthood, the frequency of EPC after stroke is unknown. The aim was to prospectively ascertain its frequency 1 year after an ischaemic stroke. METHODS:This was a prospective study of consecutive acute...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13310

    authors: Bentes C,Franco AC,Peralta AR,Viana P,Martins H,Morgado C,Casimiro C,Fonseca C,Geraldes R,Canhão P,Pinho E Melo T,Paiva T,Ferro JM

    更新日期:2017-07-01 00:00:00

  • Cerebral embolism in a patient with polycythemia rubra vera.

    abstract::Polycythemia rubra vera (PRV) is a rare haematological disorder that has a high risk of stroke, although the pathophysiological origin of the cerebral ischaemia in this disease is not well known. We report a case of a stroke patient with PRV in whom bilateral embolic signals were detected by transcranial Doppler (TCD)...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2000.00008.x

    authors: Segura T,Serena J,Teruel J,Dávalos A

    更新日期:2000-01-01 00:00:00

  • In-vivo signatures of neurodegeneration in isolated rapid eye movement sleep behaviour disorder.

    abstract:BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14215

    authors: Carli G,Caminiti SP,Galbiati A,Marelli S,Casoni F,Padovani A,Ferini-Strambi L,Perani D

    更新日期:2020-07-01 00:00:00

  • Prognostic significance of genetic biomarkers in isocitrate dehydrogenase-wild-type lower-grade glioma: the need to further stratify this tumor entity - a meta-analysis.

    abstract::The clinical outcomes of isocitrate dehydrogenase-wild-type (IDH-wt) lower-grade glioma (LGG) have been the subject of debate for some time. In this meta-analysis, we aimed to assess the prognostic values of several known genetic markers (e.g. TERT promoter mutation, H3F3A mutation, CDKN2A loss) in this tumor group. F...

    journal_title:European journal of neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ene.13826

    authors: Vuong HG,Tran TTK,Ngo HTT,Pham TQ,Nakazawa T,Fung KM,Hassell L,Katoh R,Kondo T

    更新日期:2019-03-01 00:00:00

  • Evidence of an association between Chlamydia pneumoniae and cerebrovascular accidents.

    abstract::The authors report results of a retrospective pilot study showing a strong association between patients with stroke/TIA and the presence of circulating IgG and IgA antibodies to Chlamydia pneumoniae. These results support the hypothesis that chronic active or persistent infection may play a role in the mechanism of th...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2003.00605.x

    authors: Bucurescu G,Stieritz DD

    更新日期:2003-07-01 00:00:00

  • Characteristics in childhood and adolescence associated with future multiple sclerosis risk in men: cohort study.

    abstract:BACKGROUND AND PURPOSE:Associations with multiple sclerosis (MS) of living conditions in childhood and characteristics in adolescence including physical fitness, cognitive function and psychological stress resilience were investigated. METHODS:A cohort of male Swedish residents born 1952-1956 who were included in the ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12718

    authors: Gunnarsson M,Udumyan R,Bahmanyar S,Nilsagård Y,Montgomery S

    更新日期:2015-07-01 00:00:00

  • Sapienza Global Bedside Evaluation of Swallowing after Stroke: the GLOBE-3S study.

    abstract:BACKGROUND AND PURPOSE:Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13862

    authors: Toscano M,Viganò A,Rea A,Verzina A,Sasso D'Elia T,Puledda F,Longo L,Mancini V,Ruggiero M,Jannini TB,Giuliani G,Albino F,Altieri M,Vicenzini E,Fattapposta F,Pauri F,Giacomini P,Ruoppolo G,Di Piero V

    更新日期:2019-04-01 00:00:00

  • Predictors of long-term neurological sequelae of tuberculous meningitis: a multivariate analysis.

    abstract::There is paucity of studies on predictors of long-term sequelae of tuberculous meningitis (TBM). We report the neurological sequelae of TBM at 1 year and their predictors. Patients with TBM who were followed up for 1 year were included. The diagnosis of TBM was based on clinical, cerebrospinal fluid (CSF) and computed...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01534.x

    authors: Kalita J,Misra UK,Ranjan P

    更新日期:2007-01-01 00:00:00

  • Emerging drugs for epilepsy and other treatment options.

    abstract::Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2007.01706.x

    authors: Stefan H,Steinhoff BJ

    更新日期:2007-10-01 00:00:00

  • Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson's disease patients.

    abstract::Cortical excitability of the primary motor cortex is altered in patients with Parkinson's disease (PD). Therefore, modulation of cortical excitability by high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex might result in beneficial effects on motor functions in PD. The present study...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1468-1331.2003.00649.x

    authors: Khedr EM,Farweez HM,Islam H

    更新日期:2003-09-01 00:00:00

  • Intracortical inhibition and facilitation are impaired in patients with early Parkinson's disease: a paired TMS study.

    abstract::Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian sym...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1468-1331.2003.00610.x

    authors: Bares M,Kanovský P,Klajblová H,Rektor I

    更新日期:2003-07-01 00:00:00

  • Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis.

    abstract:BACKGROUND:Prevalence rates of headache in multiple sclerosis (MS) patients varied widely in recent studies. This study aimed to investigate the 1 year prevalence of headache in MS compared with the general population. METHODS:Population-based case-control study in Germany. RESULTS:We included 491 patients with defin...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02406.x

    authors: Putzki N,Pfriem A,Limmroth V,Yaldizli O,Tettenborn B,Diener HC,Katsarava Z

    更新日期:2009-02-01 00:00:00

  • Peripapillary retinal nerve fibre layer thinning rate as a biomarker discriminating stable and progressing relapsing-remitting multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as a biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine a cut-off value of pRNFL thinning rates in relapsing-remitting MS (RRMS) to discriminate between stable and progressing patien...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13897

    authors: Bsteh G,Hegen H,Teuchner B,Berek K,Wurth S,Auer M,Di Pauli F,Deisenhammer F,Berger T

    更新日期:2019-06-01 00:00:00

  • Effect of controlled-release levodopa on the microstructure of sleep in Parkinson's disease.

    abstract:BACKGROUND:Dopamine is an important neurotransmitter in the regulation of the sleep-wake cycle, and parkinsonian patients suffer from prominent sleep abnormalities. Hence, the question arises whether the disrupted sleep pattern in Parkinson's disease (PD) is responsive to dopaminergic treatment. METHODS:Thirty-two pat...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1468-1331.2010.03213.x

    authors: Wailke S,Herzog J,Witt K,Deuschl G,Volkmann J

    更新日期:2011-04-01 00:00:00

  • Median nerve somatosensory evoked potentials in migraine.

    abstract::In visual evoked potential studies, habituation during stimulus repetition with the same stimulus at a constant intensity has been found to be abnormal in migraineurs between attacks. The purpose of this study was to investigate habituation of somatosensory evoked potentials (SEPs) and the effects of migraine on them....

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2002.00387.x

    authors: Ozkul Y,Uckardes A

    更新日期:2002-05-01 00:00:00

  • Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study.

    abstract:BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ene.13102

    authors: Nourbakhsh B,Julian L,Waubant E

    更新日期:2016-09-01 00:00:00