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ALS disease onset may occur later in patients with pre-morbid diabetes mellitus.

Abstract：

BACKGROUND:Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS. METHODS:We compared data from ALS patients with pre-morbid DM (ALS-DM; n = 175) versus without DM (ALS; n = 2196) with regard to the age of onset, rate of motor progression, survival, and neuropsychological test performance. RESULTS:The age of onset was later for women, Caucasians and patients with bulbar-onset ALS. However, we also found that after adjusting for gender, ethnicity and site of onset, DM was associated with a 4-year later onset of ALS (ALS = 56.3, ALS-DM = 60.3, P < 0.05). CONCLUSION:Diabetes mellitus type 2 may delay the onset of motor symptoms in ALS. These findings support other studies suggesting a relationship between the pathophysiology of ALS and metabolic derangements. Further investigations are needed to ascertain whether manipulating metabolic parameters would improve outcomes in ALS.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Jawaid A,Salamone AR,Strutt AM,Murthy SB,Wheaton M,McDowell EJ,Simpson E,Appel SH,York MK,Schulz PE

doi

10.1111/j.1468-1331.2009.02923.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

733-9

issue

5

eissn

1351-5101

issn

1468-1331

pii

ENE2923

journal_volume

17

pub_type

杂志文章

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