Trousseau's syndrome related to adenocarcinoma of the colon and cholangiocarcinoma.

Abstract:

:Malignancy-related thromboembolism, so-called Trousseau's syndrome, can present as acute cerebral infarction, non-bacterial thrombotic endocarditis (NBTE) and migratory thrombophlebitis. It is usually attributed to a cancer-related hypercoagulable state, chronic disseminated intravascular coagulopathy (DIC), or tumour embolism. We report on two patients with adenocarcinoma of the colon and cholangiocarcinoma who developed widespread thromboembolism during disease progression. Both did poorly despite aggressive institution of anticoagulation therapy. These cases emphasize that cerebral infarction or refractory thromboembolism in cancer-treated patients should prompt investigation for recurrent or metastatic disease or progression of the underlying malignancy. Optimal treatment remains to be established.

journal_name

Eur J Neurol

authors

Tasi SH,Juan CJ,Dai MS,Kao WY

doi

10.1111/j.1468-1331.2004.00814.x

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

493-6

issue

7

eissn

1351-5101

issn

1468-1331

pii

ENE814

journal_volume

11

pub_type

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