Abstract:
:Malignancy-related thromboembolism, so-called Trousseau's syndrome, can present as acute cerebral infarction, non-bacterial thrombotic endocarditis (NBTE) and migratory thrombophlebitis. It is usually attributed to a cancer-related hypercoagulable state, chronic disseminated intravascular coagulopathy (DIC), or tumour embolism. We report on two patients with adenocarcinoma of the colon and cholangiocarcinoma who developed widespread thromboembolism during disease progression. Both did poorly despite aggressive institution of anticoagulation therapy. These cases emphasize that cerebral infarction or refractory thromboembolism in cancer-treated patients should prompt investigation for recurrent or metastatic disease or progression of the underlying malignancy. Optimal treatment remains to be established.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Tasi SH,Juan CJ,Dai MS,Kao WYdoi
10.1111/j.1468-1331.2004.00814.xsubject
Has Abstractpub_date
2004-07-01 00:00:00pages
493-6issue
7eissn
1351-5101issn
1468-1331pii
ENE814journal_volume
11pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as a biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine a cut-off value of pRNFL thinning rates in relapsing-remitting MS (RRMS) to discriminate between stable and progressing patien...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13897
更新日期:2019-06-01 00:00:00
abstract::A 53-year-old man presented with optic neuritis, followed within 10 weeks by a subacute progression of weakness, ataxia, and multiple cranial nerve palsies. Cranial magnetic resonance imaging demonstrated multiple T2-hyperintense lesions extending from the ponto-medullary junction to the thalamus and internal capsule....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00543.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The involvement of metabolic factors in the development of dementia has received much attention. However, previous studies have yielded conflicting results regarding how blood adipocytokine level impacts cognitive decline and dementia. This study aimed to clarify whether serum high-molecular-weig...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12915
更新日期:2016-03-01 00:00:00
abstract::Digital subtraction angiography (DSA) is considered to be the 'gold standard' for confirmation of severe (70-99%) stenoses of internal carotid arteries (ICAs). However, it is associated with a risk of complications. The aim of this study was to assess the accuracy of ultrasonography (US), computed tomographic angiogra...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1331.2004.00878.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Risk-stratification models based on patient and disease characteristics are useful for aiding clinical decisions and for comparing the quality of care between different physicians or hospitals. In addition, prediction of mortality is beneficial for optimizing resource utilization. We evaluated th...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.02955.x
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:People with multiple sclerosis (MS) have to face important decisions with regard to their medical treatment. The aim of this study was to evaluate whether a targeted cognitive training reduces framing effects and thus improves medical judgments. METHODS:This was a randomized, double-blind, cross...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13778
更新日期:2019-01-01 00:00:00
abstract::Although the value of magnetic resonance imaging (MRI) for diagnosis/differential diagnosis of patients with clinically isolated syndromes suggestive of multiple sclerosis (MS) is widely accepted, adoption of MRI into clinical practice to monitor disease evolution remains a work in progress. However, an accumulating b...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.12800
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To evaluate the incidence and predictors of ischaemic recurrent stroke and the adverse events of antithrombotic therapy in patients with first intra- or extracranial vertebral artery dissection (VAD) who were treated with aspirin or oral anticoagulation (OA). METHODS:A 21-year database of consec...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03825.x
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and solubl...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14500
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Clinical outcomes vary substantially among individuals with large vessel occlusion (LVO) stroke. A small infarct core and large imaging mismatch were found to be associated with good recovery. The aim of this study was to investigate whether those imaging variables would improve individual predic...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14651
更新日期:2020-11-21 00:00:00
abstract:BACKGROUND AND PURPOSE:The deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH et...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13677
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Migraine is a complex and disabling neurological disorder, the exact neurological mechanisms of which remain unclear. The thalamus is considered to be the hub of the central processing and integration of nociceptive information, as well as the modulation of these processes. METHODS:A total of 48...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14411
更新日期:2020-11-01 00:00:00
abstract::Management of children with cerebral palsy (CP) is the focus of considerable resources in many countries, so that evaluation of the efficacy for new and established treatments is imperative. Botulinum toxin type A (BTX-A) is a relatively new method of spasticity management in children with cerebral palsy. It has been ...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1046/j.1468-1331.2001.00034.x
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms, including cognitive deficits. Several magnetic resonance imaging approaches have been applied to investigate brain atrophy in PD. The aim of this study was to detect early structural cortical a...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12785
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13102
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with the cerebellar variant of multiple system atrophy (MSA-C) often show cognitive deficits in various cognitive domains. The association between morphometric changes in cortical and subcortical structures and cognitive impairments in MSA-C were investigated to explore the neural correl...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12796
更新日期:2016-01-01 00:00:00
abstract::Phosphorylated α-synuclein (phosαSYN) containing inclusions in neurons (Lewy bodies, LB) and nerve terminals (Lewy neurites, LN), the pathological hallmark of Parkinson's disease (PD), are not confined to the central nervous system, but have also been reported in peripheral tissues. However, the usefulness of αSYN/pho...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.12753
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although Labrune syndrome is a well-known disorder characterized by a typical neuroradiological triad, namely leukoencephalopathy, intracranial calcifications and cysts, there are no reports of systemic involvement in this disorder. This paper attempts to describe a peculiar clinical manifestatio...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14313
更新日期:2020-11-01 00:00:00
abstract::Neuropathic pain treatment remains unsatisfactory despite a substantial increase in the number of trials. This EFNS Task Force aimed at evaluating the existing evidence about the pharmacological treatment of neuropathic pain. Studies were identified using first the Cochrane Database then Medline. Trials were classifie...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2006.01511.x
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12439
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Parkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only be proteins associated with disease risk but also pathways that play a role in aging. OBJECTIVE:To evaluate phenotype-modifying eff...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14733
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institute for Health and Care Excellence (NICE) in the UK recommends the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service. In view of the lack of data on the efficacy of this therapy...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13657
更新日期:2018-08-01 00:00:00
abstract::The role of genetics and its technological development have been fundamental in advancing the field of movement disorders, opening the door to precision medicine. Starting from the revolutionary discovery of the locus of the Huntington's disease gene, we review the milestones of genetic discoveries in movement disorde...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.14294
更新日期:2020-08-01 00:00:00
abstract::The levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1) were measured in the red blood cells (RBC) of 34 patients with acute ischemic hemispheric stroke on the first and seventh day after their stroke onset, and compared with 30 control individuals matched for sex, age and...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00166.x
更新日期:2001-01-01 00:00:00
abstract::In this report, we present the clinical and pathological details of a kindred of four individuals with a novel missense mutation (V272A) of the presenilin 1 gene (PSEN1) that experienced a subcortical dementia. The age of onset of symptoms ranged 26-36-year old, with an age at death of 36-46 years. Initial symptom was...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2004.00865.x
更新日期:2004-10-01 00:00:00
abstract::It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy-two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disabi...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01253.x
更新日期:2006-04-01 00:00:00
abstract::Abnormal neuronal intermediate filament (IF) inclusions immunopositive for the type IV IF alpha-internexin have been identified as the pathological hallmark of neuronal intermediate filament inclusion disease (NIFID). We studied the topography of these inclusions in the frontal and temporal lobe in 68 areas from 10 ca...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01284.x
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke are at high-risk for contracting COVID-19 infection. Additionally, healthcare professionals including neurovascular ultrasound providers are also at risk of being infected by SARS-CoV-2 virus. Yet, preparedness to continue to guarantee hyperacute treatment is v...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/ene.14334
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Falling is considered an important public health problem among older people. A recent cross-sectional study suggested that cognitive frailty (CF) is associated with falls. We aimed to explore whether CF is a risk factor for falls in a population-based longitudinal study. METHODS:Using data from ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14572
更新日期:2021-02-01 00:00:00
abstract::Jaw-opening dystonia (oromandibular dystonia with jaw-opening; Brueghel's syndrome) is a rare condition, and only a limited number of cases have been reported in the literature. However, many patients may remain undiscovered or misdiagnosed, like a patient described previously. A case (40-year-old man) of jaw-opening ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00668.x
更新日期:2003-11-01 00:00:00