Abstract:
:Management of children with cerebral palsy (CP) is the focus of considerable resources in many countries, so that evaluation of the efficacy for new and established treatments is imperative. Botulinum toxin type A (BTX-A) is a relatively new method of spasticity management in children with cerebral palsy. It has been the focus of extensive research since its application to cerebral palsy 10 years ago. In a systematic review relating to the management of the lower limb in cerebral palsy 156 papers were identified. These were categorized according to Sackett and the World Health Organisation International Classification of Impairments, Disabilities and Handicaps model. We identified 10 randomized trials evaluating the use of BTX-A in the lower limb in children with cerebral palsy in a systematic review. A meta-analysis showed the pooled risk difference between BTX-A and placebo in three trials was 0.25 (95% CI 0.13, 0.37) and 0.23 (95% CI -0.06, 0.53) for two trials of BTX-A and casting using the physicians rating scale. These represent moderate treatment effects that are dosage-dependent. Outcomes were also compared for function in five studies. The type of evidence for BTX-A was graded by each treatment indication and directions for future research were then drawn from the available evidence.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Boyd RN,Hays RMdoi
10.1046/j.1468-1331.2001.00034.xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
1-20eissn
1351-5101issn
1468-1331pii
034journal_volume
8 Suppl 5pub_type
杂志文章,评审abstract::The report focused on investigating the relationship between cigarette smoking and dementia in elderly people through prospective studies. We did a 2-year follow-up study of elderly people. A total of 2820 participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagn...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00779.x
更新日期:2004-04-01 00:00:00
abstract::In visual evoked potential studies, habituation during stimulus repetition with the same stimulus at a constant intensity has been found to be abnormal in migraineurs between attacks. The purpose of this study was to investigate habituation of somatosensory evoked potentials (SEPs) and the effects of migraine on them....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.00387.x
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13271
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12439
更新日期:2014-07-01 00:00:00
abstract::Charcot-Marie-Tooth disease (CMT) has been classified into two types: demyelinating forms (CMT1) and axonal forms (CMT2). Mutations in the CMT2A locus have been linked to the KIF1B and the mitofusin 2 (MFN2) genes. Here, we report a German patient with CMT2 with an underlying spontaneous mutation (c.281G-->A) in the M...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01688.x
更新日期:2007-05-01 00:00:00
abstract::Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2007.01706.x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13862
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed focal epilepsy (NDfE), despite it being a crucial point in time for understanding the un...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14565
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high morbidity and mortality. Minocycline is a matrix metalloproteinase-9 (MMP-9) inhibitor that may attenuate secondary mechanisms of injury in ICH. The feasibility and safety of minocycline in ICH patients were evalua...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13403
更新日期:2017-11-01 00:00:00
abstract::A 76-year-old man insidiously developed diffuse neurological symptoms: cognitive decline, dysphagia, dysphasia and mental disturbance. Computed tomography of the cranium revealed widespread bilateral brain edema and symmetrical bilateral sphenoid wing hyperostosis. Adjacent to the hyperostosis that resembled skull bas...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1999.630363.x
更新日期:1999-05-01 00:00:00
abstract::Treadmill training with partial body weight support can restore the gait ability of chronic non-ambulatory hemiparetic subjects. A combination of physiotherapy and treadmill training may accelerate the rate of recovery. Therefore a randomized study was planned. Twenty-eight non-ambulatory hemiparetic patients were ran...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1468-1331.2002.00492.x
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12289
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Depressed mood is a common psychiatric problem associated with Parkinson's disease (PD), and studies have suggested a benefit of rasagiline treatment. METHODS:ACCORDO (see the ) was a 12-week, double-blind, placebo-controlled trial to evaluate the effects of rasagiline 1 mg/day on depressive sym...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12724
更新日期:2015-08-01 00:00:00
abstract::Levodopa-carbidopa (LD) in low dosages adequately controls symptoms in most patients with Parkinson's disease and delays the appearance of fluctuations and dyskinesias. It has been suggested that early combination therapy with bromocriptine and levodopa delays or prevents the onset of late treatment complication assoc...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.530255.x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Efficacy and safety data have not previously been compiled for intramuscular interferon beta-1a (IM IFNβ-1a) in patients with multiple sclerosis (MS) ≥ 50 years of age. We investigated the efficacy and safety of IM IFNβ-1a in patients segregated by 50 and 40 years of age in separate meta-analyses. METHODS:T...
journal_title:European journal of neurology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1468-1331.2011.03460.x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dimethyl fumarate (DMF) causes a mean lymphocyte count drop of approximately 30% in relapsing-remitting multiple sclerosis (RRMS) patients. The relationship between this reduction and DMF effectiveness is controversial. The objective was to investigate if the decrease in absolute lymphocyte count...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14538
更新日期:2021-01-01 00:00:00
abstract::Between March 1996 and December 1997, 15 consecutive patients with carotid artery occlusion diagnosed with duplex sonography were treated with intravenous recombinant tissue plasminogen activator (rt-PA), following a protocol similar to that of the National Institute of Neurological Disorders and Stroke (NINDS) study....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1999.610051.x
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Portugal has been identified as one of the countries with a high prevalence of LRRK2-G2019S, considered to be the most frequent known cause of familial and sporadic Parkinson's disease (PD). The aim of this study was to evaluate the prevalence of PD in Portugal using a door-to-door methodology. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13273
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Porphyrias are a group of inherited metabolic disorders resulting from a specific deficiency along the pathway of haem biosynthesis. A clinical classification distinguishes acute from non-acute porphyrias considering the occurrence of life-threatening neurovisceral attacks, presenting with abdomi...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13347
更新日期:2017-09-01 00:00:00
abstract::Selenium is an essential component of the antioxidant enzyme glutathione peroxidase. The activity of this enzyme is reduced in the substantia nigra of patients with Parkinson's disease (PD), but the results of studies on erythrocytes are controversial. We compared the serum levels of selenium and the 24 h urinary sele...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1995.tb00102.x
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies. METHODS:...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13753
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominan...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02376.x
更新日期:2009-03-01 00:00:00
abstract::Digital subtraction angiography (DSA) is considered to be the 'gold standard' for confirmation of severe (70-99%) stenoses of internal carotid arteries (ICAs). However, it is associated with a risk of complications. The aim of this study was to assess the accuracy of ultrasonography (US), computed tomographic angiogra...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1331.2004.00878.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (AL...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03225.x
更新日期:2011-04-01 00:00:00
abstract::Upper limb spasticity affecting elbow, wrist, and finger flexors can be safely and effectively reduced with injections of botulinum toxin type-A (BoNT-A). It has been best studied in adults in the context of post-stroke spasticity. The clinical benefits include reduction in pain and deformity, improvement in washing a...
journal_title:European journal of neurology
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1111/j.1468-1331.2010.03129.x
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition. METHODS:A detailed analysis of the cognitive course of the two forms is presented, span...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12186
更新日期:2013-09-01 00:00:00
abstract::Complex painful reflex syndrome is sometimes described in the chronic phase of stroke. Acute autonomic dysfunction (AAD), which is occasionally present in cases of acute stroke, has not been studied prospectively. The aim of the study was to investigate AAD on the hemibody contralateral to the lesion in the acute phas...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01488.x
更新日期:2006-11-01 00:00:00
abstract::Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2006.01411.x
更新日期:2006-06-01 00:00:00
abstract::Glyceryl trinitrate, a prodrug of nitric oxide, induces a mild to moderate headache in healthy subjects, whilst migraineurs develop a more severe headache, resembling spontaneous migraine attacks. In order to investigate whether this increased nitric oxide sensitivity depends upon the frequency of spontaneously occurr...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00094.x
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12169
更新日期:2013-09-01 00:00:00