CD44s and CD44v6 in diagnosis and prognosis of human bladder cancer.

Abstract:

UNLABELLED:The cell adhesion molecules (CAMs) CD44 standard (CD44s) and its variant 6 (CD44v6) are involved in the progression and invasion of human malignancies. However, discrepancies in the prognostic value of CD44s and CD44v6 expression need to be addressed. AIMS:To investigate the expression of CD44s and CD44v6 in bladder carcinomas and relate the results to the established prognostic factors. MATERIALS AND METHODS:50 bladder carcinoma specimens, 30 cases with transitional cell carcinoma (TCC: 6 bilharzial and 24 nonbilharzial) and 20 cases with squamous cell carcinoma (SCC: 8 bilharzial and 12 nonbilharzial), were included. Immunohistochemical analysis for CD44s and CD44v6 was carried out using avidin-biotin peroxidase method. RESULTS:The level of both CD44s and CD44v6 in TCC was significantly higher in invasive than in preinvasive tumors and normal urothelium (p < .05). A direct association between the percentage of expression of both markers and the grade of TCC (p < .05) was observed. An inverse correlation between CD44s and SCC was seen, where metaplastic urothelium showed higher expression than invasive carcinomas. No association was observed between the expressions of both CD44s and CD44v6 and bilharzial ova, sex and age of the patient, or size of the tumor. CONCLUSIONS:The authors report statistically significant correlation between CD44s and CD44v6 expression and increasing grade and stage of TCC. No such correlation with SCC and with bilharzial cystitis, sex and age of the patient, or size of the tumor was documented.

journal_name

Ultrastruct Pathol

authors

Omran OM,Ata HS

doi

10.3109/01913123.2011.651522

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

145-52

issue

3

eissn

0191-3123

issn

1521-0758

journal_volume

36

pub_type

杂志文章
  • Neutrophil fate in gingival crevicular fluid.

    abstract::The fate of the neutrophils within the inflammatory exudate in the periodontal crevice and their possible participation in the formation of neutrophil extracellular traps (NETs) are of clinical interest. However, the cytological analysis of clinical samples of inflammatory exudate is restricted by the obtainable quant...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913120903419989

    authors: Vitkov L,Klappacher M,Hannig M,Krautgartner WD

    更新日期:2010-02-01 00:00:00

  • Immunolocalization of cellular fibronectins in the normal liver, cirrhosis, and hepatocellular carcinoma.

    abstract::Cellular (c) fibronectins (Fn) differ biochemically, immunologically, and functionally from plasma fibronectins (pFn). Most existing data on Fn distribution in the normal and diseased liver require revision because those studies were based on reagents that did not distinguish pFn from cFn and predated the development ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129509014601

    authors: Koukoulis GK,Shen J,Virtanen I,Gould VE

    更新日期:1995-01-01 00:00:00

  • Fatal pulmonary microsporidiosis due to encephalitozoon cuniculi following allogeneic bone marrow transplantation for acute myelogenous leukemia.

    abstract::Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of mic...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120590951257

    authors: Orenstein JM,Russo P,Didier ES,Bowers C,Bunin N,Teachey DT

    更新日期:2005-05-01 00:00:00

  • Heterogeneity of malignant schwannomas.

    abstract::Six malignant schwannomas were studied by electron microscopy and immunohistochemistry for S-100 protein at the light and electron microscopic levels to clarify the nature of the tumor cells. Three tumors (group A) were composed of poorly differentiated tumor cells and showed no immunoreactivity for S-100 protein. One...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809048479

    authors: Hirose T,Sano T,Hizawa K

    更新日期:1988-01-01 00:00:00

  • Xanthogranulomatous appendicitis--an incidental finding of localized pathology.

    abstract::The clinical, histopathological, and electron microscopic features of an unusual case of xanthogranulomatous appendicitis are reported. The patient, a 37-year-old female, presented with typical signs of acute appendicitis and the appendix appeared slightly dilated at laparatomy. The histopathological sections showed n...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131200281291

    authors: Munichor M,Kerner H,Cohen H,Bickel A,Iancu TC

    更新日期:2000-01-01 00:00:00

  • 5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas.

    abstract::Aberrant transcription of the FHIT gene has been observed in many solid tumors, suggesting that 5'-CpG island methylation of the FHIT gene is involved in tumor development. The authors investigated the status of the 5'-CpG island methylation of the FHIT gene and protein expression in a series of 40 cervical carcinomas...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120390250329

    authors: Wu Q,Shi H,Suo Z,Nesland JM

    更新日期:2003-11-01 00:00:00

  • The extracellular space in the edematous human cerebral cortex: an electron microscopic study using cortical biopsies.

    abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120902787076

    authors: Castejon OJ

    更新日期:2009-01-01 00:00:00

  • Glomerulocystic disease and lupus glomerulonephropathy.

    abstract::A renal biopsy demonstrated the presence of both glomerulocystic disease (GCD) and lupus glomerulonephropathy in a patient who was admitted for an unrelated disease and was found to have proteinuria and renal failure. Of 12 adult patients with GCD reported in the literature, some form of glomerulonephropathy was demon...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913129409016284

    authors: Carstens HB,Nassar RN

    更新日期:1994-01-01 00:00:00

  • A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.

    abstract::Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/01913123.2013.815081

    authors: Funkhouser WK 3rd,Niethammer M,Carson JL,Burns KA,Knowles MR,Leigh MW,Zariwala MA,Funkhouser WK Jr

    更新日期:2014-08-01 00:00:00

  • Malignant mesothelioma with intracytoplasmic crystalline inclusions.

    abstract::A 60-year-old female presented with a history of hoarseness, cough, chest pain, and dyspnea and a needle biopsy sample was submitted for histology. Light microscopy showed sheets of tumor cells with eosinophilic cytoplasm containing multiple crystals and eccentrically located nuclei. Electron microscopy showed large i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120601172489

    authors: Goedhals J,Beukes CA,Cooper S

    更新日期:2007-01-01 00:00:00

  • Dermal Langerhans' cell tumor in chronic myelomonocytic leukemia.

    abstract::Disseminated dermal tumors in a 71-year-old male represented the first clinical manifestation of a chronic myelomonocytic leukemia. The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for S-100 pr...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809058219

    authors: Kaiserling E,Horny HP

    更新日期:1988-03-01 00:00:00

  • An ultrastructural study of mast cell interactions in hemangiomas.

    abstract::Hemangiomas, the most common tumors of infancy, are characterized by a postnatal period of rapid growth, followed by a phase of gradual involution. The proliferative phase is characterized by increased numbers of endothelial and mast cells and thickened basement membrane. Ultrastructural analysis of hemangiomas in the...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128609014593

    authors: Dethlefsen SM,Mulliken JB,Glowacki J

    更新日期:1986-01-01 00:00:00

  • Epididymal ultrastructural changes associated with chronic cholestasis after bile duct ligation in adult rats.

    abstract::Testicular atrophy and testesterone insufficiency have been commonly reported associated with chronic liver diseases. Though testosterone dependent, the epididymal changes induced by liver disease have never been studied before. Thus, this study aimed to assess the ultrastructural events in the epididymis of rats with...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2018.1488789

    authors: Mahmoud YI,Abo-Zeid FS

    更新日期:2018-07-01 00:00:00

  • Value of electron microscopy in the diagnosis of glomerular diseases.

    abstract::To evaluate the contribution of electron microscopy to the final diagnosis of glomerulopathies, the authors established a prospective study during the first semester of 2006. A total of 52 kidney biopsies were performed with 3 samples for light microscopy, immunofluorescence, and electron microscopy. Among these renal...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913120903506637

    authors: Darouich S,Goucha RL,Jaafoura MH,Moussa FB,Zekri S,Maiz HB

    更新日期:2010-04-01 00:00:00

  • Myoepithelioma: definitions and diagnostic criteria.

    abstract::Due to their infrequency and multiplicity of histopathology, myoepitheliomas present difficulties in diagnosis and classification. Cellular varieties can be misdiagnosed as malignancies. Improvements in and clarification of diagnostic criteria are, therefore, required. A key to determining diagnostic criteria for myoe...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913129509021906

    authors: Dardick I

    更新日期:1995-09-01 00:00:00

  • Ultrastructural GABA immunogold labeling in the substantia nigra pars reticulata of kindled genetic absence epilepsy rats.

    abstract::Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a well-known animal model of absence epilepsy and they are resistant to electrical kindling stimulations. The present study aimed to examine possible differences in gamma-aminobutyric acid (GABA) levels and synapse counts in the substantia nigra pars reticulata ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2020.1839153

    authors: Sirvanci S,Akakin D,Gulcebi İdrizoglu M,Kaya OT,Karamahmutoglu T,Turgan Aşık ZN,Onat F

    更新日期:2020-11-20 00:00:00

  • Actin cytoskeleton reorganization correlates with cofilin nuclear expression and ultrastructural changes in cho aa8 cell line after apoptosis and mitotic catastrophe induction by doxorubicin.

    abstract::The effect of doxorubicin on the expression of cofilin and actin in CHO AA8 cells was estimated by fluorescence and electron microscopy. The presence of cofilin and actin was observed particularly in the nuclei of cells by different modes after treatment by doxorubicin. Cells undergoing mitotic catastrophe expressed s...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2010.548113

    authors: Grzanka D,Marszałek A,Izdebska M,Gackowska L,Andrzej Szczepanski M,Grzanka A

    更新日期:2011-05-01 00:00:00

  • Large block embedding and "pop-off" technique for immunoelectron microscopy.

    abstract::A technique for immunoelectron microscopy is described whereby tissue is embedded in large (6 x 12 mm) plastic blocks and reembedded ("popped off") directly from semithin (3-microns) sections for thin sectioning. This technique is particularly useful in locating relatively sparse cells or tissue structures. Three acry...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209074550

    authors: de Mesy Jensen KL,di Sant'Agnese PA

    更新日期:1992-01-01 00:00:00

  • Testicular stromal tumor: ultrastructural, immunohistochemical, and gel electrophoretic evidence of epithelial differentiation.

    abstract::A testicular tumor, removed from a 52-year-old man, was composed of uniform spindle cells and abundant interposed collagen, and was histologically diagnosed as a stromal tumor. Electron microscopy revealed cords of cells sometimes surrounded by a basal lamina. Desmosome-like junctions were found between some cells, an...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128609007209

    authors: Miettinen M,Salo J,Virtanen I

    更新日期:1986-01-01 00:00:00

  • Paraproteinemic crystalloidal keratopathy: an ultrastructural study of two cases, including immunoelectron microscopy.

    abstract::The ultrastructural appearances of corneal crystalloidal deposits are described in two patients with an IgG-kappa paraproteinemia of uncertain pathogenesis. The crystalloids in one patient were overwhelmingly intracellular and were found mainly in stromal keratocytes, but also in basal corneal epithelial cells and the...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913129309027800

    authors: Henderson DW,Stirling JW,Lipsett J,Rozenbilds MA,Roberts-Thomson PJ,Coster DJ

    更新日期:1993-11-01 00:00:00

  • Diagnostic significance of mitochondria in four types of renal epithelial neoplasms: an ultrastructural study of 60 tumors.

    abstract::Mitochondrial morphology was studied in 60 renal epithelial neoplasms, including clear cell, papillary, chromophobe cell, and oncocytomas, to see if there are significant differences among the various subtypes. Mitochondria from the nephron tubular system obtained from 36 patients with glomerular diseases served as co...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709021939

    authors: Erlandson RA,Shek TW,Reuter VE

    更新日期:1997-09-01 00:00:00

  • Myocardiocyte ultrastructure and morphometrical analysis in hamsters experimentally infected with Trypanosoma cruzi.

    abstract::The aim of this work was the study of ultrastructural morphologic and morphometric changes in myocardiocytes from chronic chagasic hamsters (Mesocricetus auratus), comparatively with changes described in other animal models and in human Chagas disease. Four chagasic animals and three nonchagasic controls were studied....

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131290923974

    authors: Colmanetti FH,Teixeira Vde P,Rodrigues ML,Chica JE,Reis Md,dos Santos VM

    更新日期:2005-03-01 00:00:00

  • Spectrum of low-grade fibrosarcomas: a comparative ultrastructural analysis of low-grade myxofibrosarcoma and fibromyxoid sarcoma.

    abstract::Low-grade fibrosarcomas have recently gained increasing attention in the literature, especially with the fall in popularity polls of the ubiquitous malignant fibrous histiocytoma (MFH). Firstly, most tumors previously known as myxoid MFH are labeled presently as myxofibrosarcomas. Secondly, the recognition and better ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131290882259

    authors: Antonescu CR,Baren A

    更新日期:2004-09-01 00:00:00

  • Evolutionary origin of eukaryotic cells.

    abstract::This article reviews literature on the transition from rudimentary prokaryotic life to eukaryotes. An overview of the differences between these organisms and theories of eukaryogenesis are reviewed. Various methods of investigating the transformation from prokaryotes to eukaryotes are elaborated, including the fossil,...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.1080/01913120050118521

    authors: Kostianovsky M

    更新日期:2000-03-01 00:00:00

  • Inflammatory fibroid polyp of the small intestine: ultrastructural and immunohistochemical observations.

    abstract::The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histiocytic features, with ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913129009025123

    authors: Suster S,Robinson MJ

    更新日期:1990-03-01 00:00:00

  • Ultrastructural myopathology in the molecular era.

    abstract::Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913123.2013.810690

    authors: Goebel HH,Stenzel W

    更新日期:2013-10-01 00:00:00

  • Ultrastructural changes of extraocular muscles in strabismus patients.

    abstract::Strabismus is an ocular disorder characterized by partial or complete inability to keep eye alignment. It represents a very common ocular problem at ophthalmology clinics worldwide. The current study aimed to show the most encountered ultrastructural changes in extraocular muscles (EOMs) collected from patients with d...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2019.1671927

    authors: Al-Falki Y,Al-Shraim M,Alsabaani NA,Eid RA,Radad K

    更新日期:2019-01-01 00:00:00

  • Differences in nuclear pore density among human choroidal melanoma cell types.

    abstract::Two cases of mixed cell type choroidal melanoma were examined by means of conventional and freeze-fracture electron microscopy. Data on average nuclear pore density were readily collected from freeze-fracture replicas of spindle A, spindle B, and epithelioid cells. Highly significant (p less than 0.001) differences in...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129009032246

    authors: Sacks-Wilner R,Freddo TF

    更新日期:1990-07-01 00:00:00

  • Myofibrosarcoma of the upper jawbones: a clinicopathologic and ultrastructural study of two cases.

    abstract::Two problematic spindle cell sarcomas involving upper jawbones in two adult male patients have been studied by histology, immunohistochemistry, and transmission electron microscopy, and respectively graded as low-grade malignancy and high-grade malignancy. While any single methodological study did not allow confident ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131201317101261

    authors: Bisceglia M,Tricarico N,Minenna P,Magro G,Pasquinelli G

    更新日期:2001-09-01 00:00:00

  • Tumor multiplicity is an independent prognostic factor of non-muscle-invasive bladder cancer treated with Bacillus Calmette-Guerin immunotherapy.

    abstract:BACKGROUND:Bacillus Calmette-Guerin (BCG) immunotherapy is regarded as the current treatment of choice for non muscle invasive bladder cancer (NMIBC), though its efficacy is limited by high recurrence and progression rate. Identification of factor prognosticators that might be helpful in discriminating between responde...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2012.681833

    authors: Ajili F,Manai M,Darouiche A,Chebil M,Boubaker S

    更新日期:2012-10-01 00:00:00