Abstract:
:The aim of this work was the study of ultrastructural morphologic and morphometric changes in myocardiocytes from chronic chagasic hamsters (Mesocricetus auratus), comparatively with changes described in other animal models and in human Chagas disease. Four chagasic animals and three nonchagasic controls were studied. Mitochondria changes were the most conspicuous findings, varying from swelling to complete organelle destruction. Noteworthy, T-tubules appeared tortuous and interrupted at the Z-line level and there was dehiscence in intercalated disks, especially in adherens junctions;in addition, the myofibrils were separated from each other by intracellular edema, with mild to accentuated focal lyses. In morphometric analysis, both the numeric density and the area of mitochondria from chagasic and normal control animals were statistically similar; however, the infected hamsters showed statistically significant enlarged sarcomeres and reduced myofibril thickness. Based on the morphologic and morphometric characteristics observed in these experimental animals, one may conclude that heart changes described at light microscopy in human Chagas disease can have a substrate on electron microscopy. Moreover, the hamster also constitutes a useful animal model to pathology studies in Chagas disease on electron microscopy.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Colmanetti FH,Teixeira Vde P,Rodrigues ML,Chica JE,Reis Md,dos Santos VMdoi
10.1080/019131290923974subject
Has Abstractpub_date
2005-03-01 00:00:00pages
139-47issue
2eissn
0191-3123issn
1521-0758journal_volume
29pub_type
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