Testicular stromal tumor: ultrastructural, immunohistochemical, and gel electrophoretic evidence of epithelial differentiation.

Abstract:

:A testicular tumor, removed from a 52-year-old man, was composed of uniform spindle cells and abundant interposed collagen, and was histologically diagnosed as a stromal tumor. Electron microscopy revealed cords of cells sometimes surrounded by a basal lamina. Desmosome-like junctions were found between some cells, and immunostaining for desmoplakins was positive. Immunofluorescence studies also showed cytokeratin-positivity in most and vimentin-positivity in some of the tumor cells. The presence of typical simple epithelial cytokeratins of Mr 40000, 45000 and 52000 was revealed by the western blotting method. Cytokeratin positivity in the tumor cells suggests the epithelial nature of this mesenchymal-looking tumor. The tumor might arise from cytokeratin-positive epithelial elements of the testis or its covering mesothelium, but the histogenesis remains unresolved. Our findings suggest that some of the so-called testicular stromal tumors may in fact be of epithelial nature by presenting features typical of epithelial differentiation.

journal_name

Ultrastruct Pathol

authors

Miettinen M,Salo J,Virtanen I

doi

10.3109/01913128609007209

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

515-28

issue

6

eissn

0191-3123

issn

1521-0758

journal_volume

10

pub_type

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