Abstract:
:The ultrastructure of 10 myxoid liposarcomas from 9 patients is presented. Features closely resembling those of developing fetal adipose tissue were seen in all tumors. THe various cell types identified ranged from undifferentiated cells to typical multivacuolated and univacuolated lipoblasts. In addition, a secretory type mesenchymal cell with distended cisternae of rough endoplasmic reticulum was found in every case as well as intermediate cells with secretory product and lipid accumulation. relative proportions of these types varied from case to case. A prominent feature in all cases was the particular spatial relationship of the abundant capillaries to the various cell types. The undifferentiated cells had perivascular processes with a tendency to envelop the primitive capillaries. These cells progressively enlarged and acquired features of the differentiated cell types as they separated from the lamina. Mitotic activity, when detectable, was prominent in the capillary wall and its vicinity. Lipoblasts resembling those of brown adipose tissue frequently coexisted in the same tumor with others analogous to those of white adipose tissue. Our findings suggest that tumor cells in liposarcoma originate from a dividing population of perivascular mesenchymal cells, in a manner akin to that of developing white adipose tissue.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Battifora H,Nunez-Alonso Cdoi
10.3109/01913128009141413subject
Has Abstractpub_date
1980-04-01 00:00:00pages
157-69issue
2eissn
0191-3123issn
1521-0758journal_volume
1pub_type
杂志文章abstract::Thirteen malignant mesotheliomas of a sarcomatous type were studied by light microscopy and ten were studied by electron microscopy. The histologic patterns varied from tumor to tumor, often resembling other soft tissue sarcomas. Electron microscopic observation showed most of the tumors to be composed of primitive ce...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309140587
更新日期:1983-06-01 00:00:00
abstract::In the last two decades, the ability of mesangial cells to respond to various stimuli or injurious agents by altering their phenotype and function has become recognized. The plasticity of these mesangial cells has been linked to the morphological and functional alterations responsible for the pathologic findings. Many...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/01913120600932594
更新日期:2006-11-01 00:00:00
abstract::The morphological changes found in kidneys of patients undergoing chronic Cyclosporine A (CSA) treatment could, despite of numerous attempts, not yet be reproduced in reliable experimental models. The purpose of the present investigation was to systematically scan the in vivo fixed kidneys in CSA treated Wistar rats a...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128709048438
更新日期:1987-01-01 00:00:00
abstract::Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2018.1463337
更新日期:2018-05-01 00:00:00
abstract::Electron microscopy of the central nervous system surface structure is described in two fetuses with Fukuyama congenital muscular dystrophy (FCMD). In addition to relatively large surface defects, many minute defects less than several micrometers in size associated with protrusion of glial cytoplasm were observed in t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709021933
更新日期:1997-07-01 00:00:00
abstract::A case of lymphoid hyperplasia with prominent plasmacytic proliferation histologically and with polyclonal hypergammaglobulinemia and anemia clinically was reported. This condition in a 54-year-old Japanese male was probably a type of plasma cell dyscrasia similar to a plasma cell variant of Castleman's disease. About...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128409018570
更新日期:1984-01-01 00:00:00
abstract::Clear-cell carcinomas of the female genital tract are uncommon tumors that usually arise in the ovary, cervix, or vagina. The objectives of the present study were to examine the immunohistochemical and ultrastructural characteristics of 18 of these tumors and to determine whether any distinctive features were present ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016357
更新日期:1996-11-01 00:00:00
abstract::Giant cell carcinoma of the lung (GCCL) is an uncommon and extremely aggressive variant of lung cancer. Characteristic microscopic findings include marked pleomorphism, aggregates of mononucleated or multinucleated giant cells (or both), a general lack of architectural cohesiveness, extensive necrosis, and endocytosis...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109016231
更新日期:1991-03-01 00:00:00
abstract::Primary ciliary dyskinesia (PCD) is a genetic disorder causing chronic oto-sino-pulmonary disease. No single diagnostic test will detect all PCD cases. Transmission electron microscopy (TEM) of respiratory cilia was previously considered the gold standard diagnostic test for PCD, but 30% of all PCD cases have either n...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/01913123.2017.1362088
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to examine the effect of the different protein supports in the cryopreservation solution on improving human ovarian tissue preservation after frozen-thawed procedures. Biopsies of ovarian cortical tissue were obtained from 14 subjects. All specimens were cryopreserved using a slow freezing/ra...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120600820187
更新日期:2006-07-01 00:00:00
abstract::A new rapid method for the processing of biopsy specimens for electron microscopy is described. The method uses standard reagents and media and employs ultrasonic cleaning bath agitation to accelerate fluid exchange. The procedure takes approximately 2.5 h from specimen excision to polymerized block and gives excellen...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109021307
更新日期:1991-01-01 00:00:00
abstract::Disseminated dermal tumors in a 71-year-old male represented the first clinical manifestation of a chronic myelomonocytic leukemia. The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for S-100 pr...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128809058219
更新日期:1988-03-01 00:00:00
abstract::Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVI...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::A 15-year-old girl presented with a small, indolent mass near the knee joint. Light microscopy revealed a peculiar myxoid plexiform tumor composed of cytologically bland cells. Interpretation of the initial biopsy material was controversial. Subsequent immunohistochemical studies revealed tumor cells to be strongly re...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129309027771
更新日期:1993-05-01 00:00:00
abstract::The coagulation process, including thrombin, fibrin, as well as platelets, plays an important role in hemostasis, contributing to the general well-being of humans. Fibrin formation and platelet activation are delicate processes that are under the control of many small physiological events. Any one of these many proces...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120701376105
更新日期:2007-03-01 00:00:00
abstract::In vivo and animal models of monoclonal light chain-associated renal diseases are limited. The Vk*MYC transgenic model with multiple myeloma in 50-70 weeks old mice with renal involvement has been reported before, but detailed renal pathologic changes have not been well documented. This study fully investigated pathol...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2020.1841349
更新日期:2020-11-20 00:00:00
abstract::Recently, interest has been increasing for human decellularized matrices, due to their ability to reduce numerous side effects related to hernia repair. To date, only animal studies investigated the biological interaction post-implant of human decellularized matrices for soft tissue repair. Therefore, the aim of this ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2017.1365788
更新日期:2018-01-01 00:00:00
abstract::Since 1980 when Sibley and coworkers first described a nodal neoplasm of unknown histogenesis with striking surface microvilli for which they introduced the term "anemone cell," a series of reports have appeared in the literature illustrating tumors with similar ultrastructural features. While most reported cases show...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120309931
更新日期:2003-03-01 00:00:00
abstract::The ultrastructure of the developing bronchiolar cell was studied in six age groups: prenatal (60 d post-conception); postnatal (1-, 7-, 14- and 21-day-old); and adult. Following intratracheal fixation, the lung tissue was processed for scanning and transmission electron microscopy. The lining of terminal bronchioles ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2015.1013654
更新日期:2015-01-01 00:00:00
abstract::The ultrastructural appearance of an endometrial stromal nodule with prominent smooth and skeletal muscle differentiation is described. This is the first reported case of endometrial stromal nodule with a heterologous skeletal muscle component and emphasizes the value of electron microscopy and its correlation with im...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129309027783
更新日期:1993-05-01 00:00:00
abstract::Hydrosalpinx is a disease commonly observed in women and characterized by the obstruction which is in the shape of a fluid-filled sac at the distal part of tuba uterina closed to the ovary. In this study, we aimed to obtain endometrial tissue samples from the hydrosalpinx patients, before and after the surgical treatm...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2019.1600087
更新日期:2019-01-01 00:00:00
abstract::The authors report the light microscopic and ultrastructural features in one case of malakoplakia involving the kidney, the urinary bladder, and the skin. The kidney was excised. Lesions of the urinary bladder and the skin regressed after topical treatment with cholinergic agonists and antimicrobial drugs. This case i...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709016374
更新日期:1997-11-01 00:00:00
abstract::A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120490475707
更新日期:2004-05-01 00:00:00
abstract::Ultrastructural findings in three cases of gastric carcinoma with coagulative necrosis are reviewed with special emphasis on microvascular changes. Intratumoral microvasculature revealed more or less stabilized vessels. Some were characterized by a close association between pericytes and endothelial cells, whereas oth...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120802289231
更新日期:2008-09-01 00:00:00
abstract::The aim of this study was to investigate the myotoxic effects of bupivacaine, ropivacaine, and levobupivacaine which were applied intramuscularly to rat skeletal muscle. Forty Wistar-Albino rats were divided into four groups. In the study, .5% bupivacaine (Group B), .5% ropivacaine (Group R), .5% levobupivacaine (Grou...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2015.1014610
更新日期:2015-05-01 00:00:00
abstract::A slowly growing tumor in the right shoulder of a 38-year-old white male, which felt like a superficial cystic mass, was studied. The spindle cells, which represented the main component of the tumor, were arranged in a typical storiform pattern and were positive for CD34 and focally for CD117. The pigmented cells were...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120309935
更新日期:2003-05-01 00:00:00
abstract::The electron microscope has been used with great skill in many aspects of the acquired immunodeficiency syndrome. It has played a critical role in classifying the human immunodeficiency virus, in characterizing the morphogenesis and gene products of the virus, and in elucidating the host cell targets and interactions....
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913129209074561
更新日期:1992-01-01 00:00:00
abstract::Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913121003788729
更新日期:2010-10-01 00:00:00
abstract::Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913123.2013.810690
更新日期:2013-10-01 00:00:00
abstract::The effect of doxorubicin on the expression of cofilin and actin in CHO AA8 cells was estimated by fluorescence and electron microscopy. The presence of cofilin and actin was observed particularly in the nuclei of cells by different modes after treatment by doxorubicin. Cells undergoing mitotic catastrophe expressed s...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2010.548113
更新日期:2011-05-01 00:00:00