Programmed cell death of peripheral myeloid precursor cells in Down patients: effect of zinc therapy.

Abstract:

:Hemopoietic stem cell differentiation represents the primary rule of self-renewal, proliferation, and specialization modulated by several mechanisms, including growth factors, cell interactions, and bioavailability of various ions, especially Ca2+ and Zn2+. Apoptotic death, during normal cell turnover, has been widely studied and is recognized as an important pathway for clonal deletion in the hemopoietic system. Multiparametric analyses have shown that subjects with Down syndrome show low levels of plasmic zinc associated with the presence of immature myeloid cells in the peripheral blood. This arrangement is repaired by in vivo zinc therapy. This study presents morphological and biochemical analyses to show that ZnSO4 therapy induces the disappearance of peripheral myeloid precursor cells by a programmed cell death mechanism. The programmed zinc-therapy-induced cell death presumably provides a simple way to regulate the myeloid differentiation selecting appropriate cells.

journal_name

Ultrastruct Pathol

authors

Trubiani O,Antonucci A,Palka G,Di Primio R

doi

10.3109/01913129609016349

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

457-62

issue

5

eissn

0191-3123

issn

1521-0758

journal_volume

20

pub_type

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