Abstract:
:Hemopoietic stem cell differentiation represents the primary rule of self-renewal, proliferation, and specialization modulated by several mechanisms, including growth factors, cell interactions, and bioavailability of various ions, especially Ca2+ and Zn2+. Apoptotic death, during normal cell turnover, has been widely studied and is recognized as an important pathway for clonal deletion in the hemopoietic system. Multiparametric analyses have shown that subjects with Down syndrome show low levels of plasmic zinc associated with the presence of immature myeloid cells in the peripheral blood. This arrangement is repaired by in vivo zinc therapy. This study presents morphological and biochemical analyses to show that ZnSO4 therapy induces the disappearance of peripheral myeloid precursor cells by a programmed cell death mechanism. The programmed zinc-therapy-induced cell death presumably provides a simple way to regulate the myeloid differentiation selecting appropriate cells.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Trubiani O,Antonucci A,Palka G,Di Primio Rdoi
10.3109/01913129609016349subject
Has Abstractpub_date
1996-09-01 00:00:00pages
457-62issue
5eissn
0191-3123issn
1521-0758journal_volume
20pub_type
临床试验,杂志文章abstract::A technique is described in which areas of large Spurr epoxy thick sections are directly popped off of glass slides by inverted Beem capsules filled with polymerized plastic. This technique allows the survey of large regions of tissue with the maintenance of tissue relationships and the selection of specific areas for...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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