Abstract:
:Neuroblastic tumors have the unique ability to differentiate and mature. This family of tumors is composed of the neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. These tumors are derived from primordial neural crest cells that form the sympathetic nervous system. The purpose of this study was to characterize the ultrastructural features of neuroblastic tumors in a pediatric population. Forty-five neuroblastic tumors (15 neuroblastomas, 15 ganglioneuroblastomas, and 15 ganglioneuromas) were examined using standard transmission electron microscopic techniques. Undifferentiated neuroblastomas were composed of primitive cells with rare neurite-like processes containing clear secretory vesicles and no Schwann cell differentiation. Poorly differentiated and differentiating neuroblastomas showed more frequent neuritic processes with infrequent dense core granules and infrequent immature Schwann-like cells. Ganglioneuroblastomas possessed an admixture of cell types, including immature ganglion cells without associated satellite cells, intermediate cells, and differentiating neuroblasts. The neuropil contained immature Schwann cells encasing haphazardly arranged neuritic processes. Ganglioneuromas were composed of mature ganglion cells with occasional binucleation. The neuropil contained mature Schwann cells with well-organized neuritic processes and abundant collagen deposition. Differentiation or maturation of tumor cells, neuritic processes, and Schwann cells may thus be discerned ultrastructurally in primary neuroblastic tumors in pediatric patients.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Hicks MJ,Mackay Bdoi
10.3109/01913129509064236subject
Has Abstractpub_date
1995-07-01 00:00:00pages
311-22issue
4eissn
0191-3123issn
1521-0758journal_volume
19pub_type
杂志文章abstract::The aim of this study is to investigate the effects of betulinic acid (BA) on triple-negative breast cancer MDA-MB-231 cells and observe the ultrastructural changes. The concentration of BA required to induce apoptosis in MDA-MB-231 cells has been previously reported. In this study, a cell counting kit-8 proliferation...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
abstract::Sibutramine is used in the treatment of obesity due to its ability to influence feelings of hunger and satiety by inhibiting the re-uptake of serotonin and noradrenalin in the central nervous system (CNS). Sibutramine use has been associated with numerous adverse events in particular cardiovascular complications possi...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128409018570
更新日期:1984-01-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128109048309
更新日期:1981-07-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109016260
更新日期:1991-07-01 00:00:00
abstract::An unusual case of metastatic sarcomatoid renal cell carcinoma is presented. Fifteen months after nephrectomy for a typical clear cell carcinoma, a 63-year-old man presented with bilateral pleural effusions, cardiomegaly, and tamponade. A pericardial biopsy showed an anaplastic spindle cell tumor that was strongly ker...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1982-04-01 00:00:00
abstract:UNLABELLED:The cell adhesion molecules (CAMs) CD44 standard (CD44s) and its variant 6 (CD44v6) are involved in the progression and invasion of human malignancies. However, discrepancies in the prognostic value of CD44s and CD44v6 expression need to be addressed. AIMS:To investigate the expression of CD44s and CD44v6 i...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2011.651522
更新日期:2012-05-01 00:00:00
abstract::One of the most studied onco-gene families in breast tumors is the type 1 protein tyrosine kinase family, which consists of EGFR, c-erbB-2, c-erbB-3, and c-erbB-4. Overexpression of c-erbB-2 protein/mRNA in breast carcinomas is consistently associated with poor prognosis, while EGFR overexpression has been confirmed t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/01913120290076784
更新日期:2002-05-01 00:00:00
abstract::Conidiobolus coronatus is a major insect pathogen belonging to the fungal order Entomophthorales, causing a rare subcutaneous infection of the nasofacial region, resulting in swelling of predominantly the nose, mouth, and perinasal tissue. Later in the course of the infection firm, painless, subcutaneous nodules devel...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
abstract::The ultrastructure of a benign uterine epithelioid leiomyoma with prominent clear cells ("leiomyoblastoma") was studied to define the subcellular changes that yield the distinctive light microscopic pattern of this rare lesion. The main constituent of the cytoplasm was multiple cytolysosomes composed of vesicular, mem...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128609032224
更新日期:1986-01-01 00:00:00
abstract::Six intradermal melanocytic nevi, two with and four without intercellular slitlike spaces, were examined by light microscopy and electron microscopy of deparaffinized tissue. The spaces were partially lined by elongated nevus cells and contained a few collagen fibrils. Other features in both groups included an abundan...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128009141438
更新日期:1980-07-01 00:00:00