Light and electron microscopic changes in the kidney of Wistar rats following treatment with cyclosporine A.

Abstract:

:The morphological changes found in kidneys of patients undergoing chronic Cyclosporine A (CSA) treatment could, despite of numerous attempts, not yet be reproduced in reliable experimental models. The purpose of the present investigation was to systematically scan the in vivo fixed kidneys in CSA treated Wistar rats at the light and electron microscopic level. The study revealed changes in the proximal tubules, i.e., inclusion bodies, vacuolization, microcalcifications and regeneration. Some glomeruli displayed a thickening of the parietal sheet of Bowman's capsule. At the electron microscopic level, individual necroses of myocytes in the tunica media of afferent arterioles were observed. Thus, at the ultrastructural level, the kidneys of CSA treated normotensive Wistar rats do reveal morphological changes similar to those occurring in man.

journal_name

Ultrastruct Pathol

authors

Fasel J,Kaissling B,Ludwig KS,Ryffel B,Mihatsch MJ

doi

10.3109/01913128709048438

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

435-48

issue

4

eissn

0191-3123

issn

1521-0758

journal_volume

11

pub_type

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