Ultrastructural aspects of enterocyte defects in infancy and childhood.

Abstract:

:Although there has been substantial progress in the identification of diarrheal diseases in infancy and childhood, electron microscopy may be still required for establishing diagnosis, staging, and response to therapy. This review describes severe conditions in which histopathologic examination alone cannot provide a firm diagnosis needed for therapeutic decisions. Microvillus inclusion disease, in its several variants, typifies this category. In certain forms of congenital disorders of glycosylation with gastrointestinal involvement, electron microscopic diagnosis is helpful. Among disorders due to abnormal immune-mediated reactions, celiac disease and cow's milk protein intolerance show fine structural changes of both diagnostic and staging value. Likewise, protein-losing enteropathies, including lymphangectasia, reveal information on the nature and extent of intestinal involvement.

journal_name

Ultrastruct Pathol

authors

Iancu TC,Manov I

doi

10.3109/01913121003648410

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

117-25

issue

3

eissn

0191-3123

issn

1521-0758

journal_volume

34

pub_type

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