Abstract:
:Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with transmission electron microscopy have been employed. Foremost among them is immunoelectron microscopy, which assists in guiding molecular analysis in hereditary conditions, but may be vital in diagnostics of certain acquired entities, e.g., undulating tubules in dermatomyositis and in those congenital myopathies where genes and mutations remain to be identified, as in cylindrical spirals myopathy and hexagonal crystalloid-body myopathy.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Goebel HH,Stenzel Wdoi
10.3109/01913123.2013.810690subject
Has Abstractpub_date
2013-10-01 00:00:00pages
328-31issue
5eissn
0191-3123issn
1521-0758journal_volume
37pub_type
杂志文章,评审abstract::Electron-microscopic analysis of the ultrastructure of the Krebs-2 carcinoma ascites cells in the first 90 min immediately after their exposure to fragmented double-stranded DNA has been performed. Morphological attributes of the treated cancer cells indicate the induction in these cells of destructive processes of pr...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2019.1575499
更新日期:2019-01-01 00:00:00
abstract::The coagulation process, including thrombin, fibrin, as well as platelets, plays an important role in hemostasis, contributing to the general well-being of humans. Fibrin formation and platelet activation are delicate processes that are under the control of many small physiological events. Any one of these many proces...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120701376105
更新日期:2007-03-01 00:00:00
abstract::A 71-year-old asbestos-exposed male with symptoms suggestive of asbestosis for the previous 8 years presented with abdominal distension and ascites. Clinically, a diagnosis of mesothelioma carcinoma was made. Light microscopy of an omental biopsy failed to advance the diagnosis: The tumor was a solid, papillary, and g...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016334
更新日期:1996-07-01 00:00:00
abstract::The term "neuronal ceroid lipofuscinosis" (NCL) describes a complex of inherited neurodegenerative conditions associated with storage of lipopigments in brain tissue. In 1989 Dyken proposed a classification of NCL based on the age, clinical symptoms, and ultrastructural aspects of the lipopigments. At the ultrastructu...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131201300004681
更新日期:2001-01-01 00:00:00
abstract::Excess lipofuscin deposition in tissues is a phenomenon observed in normal aging. The amount of lipofuscin in myocardium, liver, skeletal muscle, and adnexal skin structures varies considerably with age and increases in older individuals. In addition, lipofuscin deposition occurs in association with specific, non-age-...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129009076140
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Proteinuria is an uncommon clinical manifestation of IgA nephropathy and is usually seen in cases with severe lesions like endocapillary proliferation. However, it is occasionally seen even with cases with mild glomerular manifestations and may even be of nephrotic range. PREDICTOR:Podocyte foot process eff...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.960543
更新日期:2015-04-01 00:00:00
abstract::Although there has been substantial progress in the identification of diarrheal diseases in infancy and childhood, electron microscopy may be still required for establishing diagnosis, staging, and response to therapy. This review describes severe conditions in which histopathologic examination alone cannot provide a ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913121003648410
更新日期:2010-05-01 00:00:00
abstract::Cellular (c) fibronectins (Fn) differ biochemically, immunologically, and functionally from plasma fibronectins (pFn). Most existing data on Fn distribution in the normal and diseased liver require revision because those studies were based on reagents that did not distinguish pFn from cFn and predated the development ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129509014601
更新日期:1995-01-01 00:00:00
abstract::Testicular atrophy and testesterone insufficiency have been commonly reported associated with chronic liver diseases. Though testosterone dependent, the epididymal changes induced by liver disease have never been studied before. Thus, this study aimed to assess the ultrastructural events in the epididymis of rats with...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2018.1488789
更新日期:2018-07-01 00:00:00
abstract::Canova is an immunomodulatory, homeopathic preparation that has been shown to activate macrophages in vitro and in vivo, with resultant enhanced spreading of the cells and formation of microvillus extensions from the cell body. Since monocytes are the precursor cells of macrophages and dendritic cells, the objective o...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120802062729
更新日期:2008-07-01 00:00:00
abstract::A fast method for processing biologic material for electron microscopy for precise and specific diagnosis of infectious agents is an increasing necessity. After different, reportedly fast methods were tested, a useful and quick technique was developed that provides well-preserved cellular structures, enabling the etio...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209057832
更新日期:1992-07-01 00:00:00
abstract::Prolonged storage of Karnovsky's fixative, at both 4 and -20 degrees C, is possible in the diagnostic electron microscopy setting. Ultrastructural detail was not compromised in specimens processed in fixative that had been stored for 6 months. Evidence of smooth muscle and neuroendocrine differentiation was present in...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709021318
更新日期:1997-03-01 00:00:00
abstract:INTRODUCTION:Low-frequency noise (LFN) is a ubiquitous physical stressor known to cause degenerative cellular changes and organ alterations with functional repercussions both in humans and animals. MATERIALS AND METHODS:After acceptance of the study protocol by a local ethics committee, 20 Wistar rats were randomly di...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2017.1336188
更新日期:2017-07-01 00:00:00
abstract::Disseminated dermal tumors in a 71-year-old male represented the first clinical manifestation of a chronic myelomonocytic leukemia. The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for S-100 pr...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128809058219
更新日期:1988-03-01 00:00:00
abstract::The aim of this work was the study of ultrastructural morphologic and morphometric changes in myocardiocytes from chronic chagasic hamsters (Mesocricetus auratus), comparatively with changes described in other animal models and in human Chagas disease. Four chagasic animals and three nonchagasic controls were studied....
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131290923974
更新日期:2005-03-01 00:00:00
abstract::A metastasizing carcinoid of the gastric stump found 25 years after Billroth II gastric resection for duodenal ulcer is described. Electron microscopy and optical endocrine cell staining proved the tumor to be composed of enterochromaffinlike (ECL) cells. This unusual combination further shows that, at variance with m...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109021888
更新日期:1991-05-01 00:00:00
abstract::Electron microscopy defined classic patterns of hereditary glomerular disease long before genetics revealed an underlying specific mutation. Genetic analysis is now easier to perform in clinical practice but an earlier optimism that genetics would predict disease severity and phenotype is challenged. The classic parad...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/019131290505194
更新日期:2004-07-01 00:00:00
abstract::A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been speculated eventually to contain atrial natriuretic factor (ANF). The p...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409016293
更新日期:1994-01-01 00:00:00
abstract::As You Like It, Part 3, is a continuation of the lectures given by the author (Ultra Path VIII and Ultra Path IX). It is a critical historical review of topics of interest to electron microscopists, attempting to show what went wrong and perhaps also why. The topics chosen this time demonstrate the prominent role elec...
journal_title:Ultrastructural pathology
pub_type: 历史文章,杂志文章,评审
doi:10.1080/019131201300343874
更新日期:2001-05-01 00:00:00
abstract::Giant cell carcinoma of the lung (GCCL) is an uncommon and extremely aggressive variant of lung cancer. Characteristic microscopic findings include marked pleomorphism, aggregates of mononucleated or multinucleated giant cells (or both), a general lack of architectural cohesiveness, extensive necrosis, and endocytosis...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109016231
更新日期:1991-03-01 00:00:00
abstract::Three young children with characteristic fibroblastic tumors are presented. These comprised one case each of congenital fibrosarcoma, dermatofibrosarcoma protuberans, and fibrous hamartoma of infancy. Ultrastructural examination in each tumor revealed the presence of a peculiar intracisternal paracrystalline material ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128909048494
更新日期:1989-07-01 00:00:00
abstract::The objective of this study was to investigate the ultrastructural characteristics of hybrid acute leukemia (HAL). Fifteen cases of HAL were studied by transmission electron microscopy (TEM), focusing on organelles and myeloperoxidase (MPO) reaction of leukemic cells. By TEM, 5 out 15 cases of HAL were consistent with...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131290968722
更新日期:2005-09-01 00:00:00
abstract::The electron microscope has been used with great skill in many aspects of the acquired immunodeficiency syndrome. It has played a critical role in classifying the human immunodeficiency virus, in characterizing the morphogenesis and gene products of the virus, and in elucidating the host cell targets and interactions....
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913129209074561
更新日期:1992-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most commonly malignant tumors worldwide, characterized by the presence of many heterogeneous molecular cell events that contribute to tumor growth and progression. Endocytic processes are intimately involved in various pathological conditions, including cancer, since they ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2019.1701167
更新日期:2019-01-01 00:00:00
abstract::A 15-year-old girl presented with a small, indolent mass near the knee joint. Light microscopy revealed a peculiar myxoid plexiform tumor composed of cytologically bland cells. Interpretation of the initial biopsy material was controversial. Subsequent immunohistochemical studies revealed tumor cells to be strongly re...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129309027771
更新日期:1993-05-01 00:00:00
abstract::A technique is described in which areas of large Spurr epoxy thick sections are directly popped off of glass slides by inverted Beem capsules filled with polymerized plastic. This technique allows the survey of large regions of tissue with the maintenance of tissue relationships and the selection of specific areas for...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128409018580
更新日期:1984-01-01 00:00:00
abstract::To extend our initial observations that recombinant gamma-interferon (r gamma IFN) influences the growth and differentiation of normal cultured human keratinocytes, we studied the electron microscopic changes induced by r gamma IFN. Treatment of cultured human keratinocytes with 10(3) units/ml (7.1 nM) of r gamma IFN ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128609015559
更新日期:1986-01-01 00:00:00
abstract::Elastofibromas have been described as ill-defined tumors, composed of fibroblastic stromal cells and a dense collagenous stroma. A total of 5 elastofibromas from 4 Japanese patients were examined by ultrastructural and immunohistochemical methods. The proliferating fibroblastic stromal cells in the lesion showed Cx43-...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120701350365
更新日期:2007-05-01 00:00:00
abstract::Hydrosalpinx is a disease commonly observed in women and characterized by the obstruction which is in the shape of a fluid-filled sac at the distal part of tuba uterina closed to the ovary. In this study, we aimed to obtain endometrial tissue samples from the hydrosalpinx patients, before and after the surgical treatm...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2019.1600087
更新日期:2019-01-01 00:00:00
abstract::Electron microscopic investigation of biopsy materials from Kaposi sarcoma (KS) skin lesions of 2 African AIDS patients occasionally revealed fungal cells within the tumor tissue. The spherical cells were surrounded by a triple-layered cell wall and were not encapsulated. The ultrastructural characteristics of the cel...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120500520960
更新日期:2006-05-01 00:00:00