Abstract:
INTRODUCTION:Low-frequency noise (LFN) is a ubiquitous physical stressor known to cause degenerative cellular changes and organ alterations with functional repercussions both in humans and animals. MATERIALS AND METHODS:After acceptance of the study protocol by a local ethics committee, 20 Wistar rats were randomly divided into two equal groups. One group was kept in silence and the other continuously exposed to LFN during 13 weeks. The rats had unlimited access to water and were fed standard rat chow. After exposure, the animals were sacrificed and the parotid glands were excised and prepared for transmission electron microscopy. RESULTS:The acinar cells showed marked ultrastructural alterations, such as intracellular vacuolization, loss of cell polarity, increased heterochromatin, cytoplasmic inclusions, and oncocytic transformation. CONCLUSIONS:LFN induces ultrastructural changes in the rat parotid gland that correlate with previously described functional changes.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Oliveira P,Pereira GM,Simões MS,Monteiro E,Alves de Matos AP,Águas A,Martins Dos Santos Jdoi
10.1080/01913123.2017.1336188subject
Has Abstractpub_date
2017-07-01 00:00:00pages
291-295issue
4eissn
0191-3123issn
1521-0758journal_volume
41pub_type
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