Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination.

Abstract:

:Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury.

journal_name

Ultrastruct Pathol

authors

Eşrefoğlu M,Ara C

doi

10.3109/01913121003788729

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

273-8

issue

5

eissn

0191-3123

issn

1521-0758

journal_volume

34

pub_type

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