Morphologic characteristics of blastic plasmacytoid dendritic cell neoplasm: a case report.

Abstract:

:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive lymphoma derived from plasmacytoid dendritic cells or precursor dendritic cells. Despite some 240 reported cases, its morphology and especially ultrastructure has not been satisfactorily studied. A case is reported of a 13 year old boy, who, despite chemotherapy, died within a 12-month period. The electron microscopy findings - microvillous processes, nuclei with slight irregularities, a moderate amount of heterochromatin, and rough endoplasmic reticulum in the form of long, narrow profiles, often in parallel arrangements - taken together, serve to distinguish BPDCN from other neoplastic cells, such as monocytes, plasma cells and the cells of chronic lymphocyte leukemia.

journal_name

Ultrastruct Pathol

authors

Ru Y,Zhang P,Dong S,Wang H,Zhao S,Mi Y,Eyden B

doi

10.3109/01913123.2013.813998

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

66-8

issue

1

eissn

0191-3123

issn

1521-0758

journal_volume

38

pub_type

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