Abstract:
:Monomorphous pituitary adenomas expressing several hormones by immunocytochemistry are common, whereas adenomas displaying multiple immunoreactivities and consisting of more than one morphologic cell types are rare. Three such unusual pituitary adenomas, surgically removed from two patients with acromegaly and one patient with hyperprolactinemia, were investigated by histology, immunocytochemistry, transmission electron microscopy, as well as immunoelectron microscopy using double immunogold labeling. Immunocytochemistry revealed variable degrees of immunoreactivities for growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (beta-TSH), and alpha-subunit of glycoprotein hormones in all three tumors. The three adenomas consisted of phenotypically diverse cell populations as documented by transmission electron microscopy. In addition to monohormonal GH cells, immunoelectron microscopy demonstrated numerous cells colocalizing GH and PRL or GH and beta-TSH, and rarely PRL and beta-TSH in tumors of acromegalics. The adenoma causing hyperprolactinemia consisted chiefly of mammosomatotrophs colocalizing PRL and GH, whereas beta-TSH labeling was scant. The three tumors in the study were selected from a cluster of five plurimorphous plurihormonal adenomas received from the same locale where they accounted for an unprecedented 21% of adenomas producing GH and/or PRL. The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Vidal S,Syro L,Horvath E,Uribe H,Kovacs Kdoi
10.1080/019131299281635subject
Has Abstractpub_date
1999-05-01 00:00:00pages
141-8issue
3eissn
0191-3123issn
1521-0758journal_volume
23pub_type
杂志文章abstract:UNLABELLED:The cell adhesion molecules (CAMs) CD44 standard (CD44s) and its variant 6 (CD44v6) are involved in the progression and invasion of human malignancies. However, discrepancies in the prognostic value of CD44s and CD44v6 expression need to be addressed. AIMS:To investigate the expression of CD44s and CD44v6 i...
journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,随机对照试验
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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