Jaw osteonecrosis in patients treated with bisphosphonates: an ultrastructural study.

Abstract:

:Osteonecrosis of the jaw is a severe bone disorder traditionally associated with periodontal disease, local malignancy, chemotherapy, glucocorticoid therapy, or trauma. Recently a growing number of publications reported the occurrence of osteonecrosis of the jaw in patients undergoing treatment with bisphosphonates. The mechanism by which bisphosphonates might contribute to the development of osteonecrosis of the jaw is far from being fully elucidated. Suppression of bone turnover, infection, tissue hypoxia and cellular toxicity were proposed as possible mechanisms by which bisphosphonates may exert adverse effects on bone metabolism. Here, we studied 25 consecutive patients treated with bisphosphonates for osteoporosis or tumoral pathologies. We provide good evidence of hyperactive osteoclastic bone resorption and suggest a direct cytotoxic effect of bisphosphonates on bone tissue through induction of osteocyte cell death. We also demonstrate that bisphosphonates only have limited adverse effects on bone vascular network.

journal_name

Ultrastruct Pathol

authors

Perrotta I,Cristofaro MG,Amantea M,Russo E,De Fazio S,Zuccalà V,Conforti F,Amorosi A,Donato G,Tripepi S,Giudice M

doi

10.3109/01913121003729806

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

207-13

issue

4

eissn

0191-3123

issn

1521-0758

journal_volume

34

pub_type

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