Abstract:
:Osteonecrosis of the jaw is a severe bone disorder traditionally associated with periodontal disease, local malignancy, chemotherapy, glucocorticoid therapy, or trauma. Recently a growing number of publications reported the occurrence of osteonecrosis of the jaw in patients undergoing treatment with bisphosphonates. The mechanism by which bisphosphonates might contribute to the development of osteonecrosis of the jaw is far from being fully elucidated. Suppression of bone turnover, infection, tissue hypoxia and cellular toxicity were proposed as possible mechanisms by which bisphosphonates may exert adverse effects on bone metabolism. Here, we studied 25 consecutive patients treated with bisphosphonates for osteoporosis or tumoral pathologies. We provide good evidence of hyperactive osteoclastic bone resorption and suggest a direct cytotoxic effect of bisphosphonates on bone tissue through induction of osteocyte cell death. We also demonstrate that bisphosphonates only have limited adverse effects on bone vascular network.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Perrotta I,Cristofaro MG,Amantea M,Russo E,De Fazio S,Zuccalà V,Conforti F,Amorosi A,Donato G,Tripepi S,Giudice Mdoi
10.3109/01913121003729806subject
Has Abstractpub_date
2010-08-01 00:00:00pages
207-13issue
4eissn
0191-3123issn
1521-0758journal_volume
34pub_type
杂志文章abstract::The aim of this work was the study of ultrastructural morphologic and morphometric changes in myocardiocytes from chronic chagasic hamsters (Mesocricetus auratus), comparatively with changes described in other animal models and in human Chagas disease. Four chagasic animals and three nonchagasic controls were studied....
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131290923974
更新日期:2005-03-01 00:00:00
abstract::The purpose of this article has been to illustrate the applications and limitations of comparing the ultrastructural morphology of certain poorly differentiated neoplasms with normal human embryonic tissues. The examples used--embryonal rhabdomyosarcoma, Wilms' tumor, and fibrous mesothelioma, in comparison with embry...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128709048450
更新日期:1987-01-01 00:00:00
abstract::A case of Ki-1 lymphoma of the large cell anaplastic type with weak leukocyte common antigen expression is presented. These tumors can sometimes demonstrate confusing immunophenotypes (weak or negative leukocyte common antigen, pan T, pan B, HMB 45, and S-100, and anomalous positive epithelial membrane antigen stainin...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209074544
更新日期:1992-01-01 00:00:00
abstract::Myeloid histocytes of dendritic cells (DCs), Langerhans cells (LCs), and macrophages in varied tissues, as leukemic blasts in acute monoblastic and monocytic leukemia (AML-M5a and M5b), are derived from monocyte progenitors in bone marrow. Based on DC induction from hematopoietic stem cells, myeloid progenitors, and m...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2015.1120838
更新日期:2016-01-01 00:00:00
abstract::The aim of this study is to investigate the effects of betulinic acid (BA) on triple-negative breast cancer MDA-MB-231 cells and observe the ultrastructural changes. The concentration of BA required to induce apoptosis in MDA-MB-231 cells has been previously reported. In this study, a cell counting kit-8 proliferation...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2017.1383548
更新日期:2018-01-01 00:00:00
abstract::We have carried out a systematic ultrastructural study of the bacilli, the cell-mediated response in the host, and the dermal microvasculature in lepromatous (LL), borderline lepromatous (BL), and borderline tuberculoid (BT) types of active leprosy (eight cases). In the types of least resistance (LL and BL), macrophag...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409023213
更新日期:1994-07-01 00:00:00
abstract::To evaluate the contribution of electron microscopy to the final diagnosis of glomerulopathies, the authors established a prospective study during the first semester of 2006. A total of 52 kidney biopsies were performed with 3 samples for light microscopy, immunofluorescence, and electron microscopy. Among these renal...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913120903506637
更新日期:2010-04-01 00:00:00
abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902787076
更新日期:2009-01-01 00:00:00
abstract::Neuroblastic tumors have the unique ability to differentiate and mature. This family of tumors is composed of the neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. These tumors are derived from primordial neural crest cells that form the sympathetic nervous system. The purpose of this study was to characterize ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129509064236
更新日期:1995-07-01 00:00:00
abstract::Electron microscopy of the central nervous system surface structure is described in two fetuses with Fukuyama congenital muscular dystrophy (FCMD). In addition to relatively large surface defects, many minute defects less than several micrometers in size associated with protrusion of glial cytoplasm were observed in t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709021933
更新日期:1997-07-01 00:00:00
abstract::Deciduoid mesothelioma was first described in young females and in the peritoneum, which led to the suggestion that deciduoid mesothelioma was a distinct subtype with specific clinical and pathologic features. Later reports, however, have shown that this type of mesothelioma may also occur in elderly people and in the...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/0913120290104647
更新日期:2002-11-01 00:00:00
abstract::The study aims to investigate the protective effect of Pimpinella anisum oil on aspartame (ASP) which resulted in cerebellar changes. The rats were divided into four equal groups: Group 1: (control group): served as control animals. Group 2: control P. anisum oil received .5 mL/kg/d/b wt. once daily. Group 3 (ASP grou...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.889259
更新日期:2014-05-01 00:00:00
abstract::Myoepithelial cells of salivary gland are uniquely specialized cells; their function is unclear, but the considerable complement of muscle-specific actin suggests contractility is one function. By routine transmission electron microscopy myofilament visualization is variable. Some myoepithelial cells appear to have li...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209061547
更新日期:1992-09-01 00:00:00
abstract::Rapid advances have been made in recent years in understanding the genetic makeup of mankind. The human genome project has identified approximately 32,000 genes that occur in humans. It is now possible to perform genetic profiling with many of the genes to understand embryogenesis, growth and development, the normal s...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
abstract:OBJECT:To study the relationship between monocyte/histiocyte activation and myelodysplastic syndrome (MDS). METHODS:Analyzing ultrastructure and myeloperoxidase reaction of nucleated cells in bone marrow from 59 cases of MDS by transmission electron microscopy. Four groups of MDS were subdivided on the basis of their ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.888116
更新日期:2014-08-01 00:00:00
abstract::Six intradermal melanocytic nevi, two with and four without intercellular slitlike spaces, were examined by light microscopy and electron microscopy of deparaffinized tissue. The spaces were partially lined by elongated nevus cells and contained a few collagen fibrils. Other features in both groups included an abundan...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128009141438
更新日期:1980-07-01 00:00:00
abstract::Inflammatory polyneuropathies are mainly known by their acute form, Guillain-Barré syndrome, but there are also chronic cases and all are considered as having an autoimmune mechanism. In each form, peripheral nerve biopsies show scattered macrophages in the endoneurium and in certain cases macrophages invade the Schwa...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129809103359
更新日期:1998-09-01 00:00:00
abstract::The coagulation process, including thrombin, fibrin, as well as platelets, plays an important role in hemostasis, contributing to the general well-being of humans. Fibrin formation and platelet activation are delicate processes that are under the control of many small physiological events. Any one of these many proces...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120701376105
更新日期:2007-03-01 00:00:00
abstract::Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913121003788729
更新日期:2010-10-01 00:00:00
abstract::By means of optical and electron microscopy and by atomic absorption spectrophotometry in a graphite chamber, this study evaluated the effect of temperature (22-35 degrees C) on lesions in the kidney, liver, and brain, and on concentrations of lead caused by the administration of 2 and 5 mg/kg/IP of lead acetate to Sw...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016324
更新日期:1996-05-01 00:00:00
abstract::Disseminated dermal tumors in a 71-year-old male represented the first clinical manifestation of a chronic myelomonocytic leukemia. The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for S-100 pr...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128809058219
更新日期:1988-03-01 00:00:00
abstract::Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel di...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.829150
更新日期:2015-02-01 00:00:00
abstract::Primary ciliary dyskinesia (PCD) is a genetic disorder causing chronic oto-sino-pulmonary disease. No single diagnostic test will detect all PCD cases. Transmission electron microscopy (TEM) of respiratory cilia was previously considered the gold standard diagnostic test for PCD, but 30% of all PCD cases have either n...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/01913123.2017.1362088
更新日期:2017-11-01 00:00:00
abstract::Eighty-four cortical neoplasms were studied for cytokeratin and vimentin expression by immunohistochemistry and for intermediate filament aggregates by electron microscopy. Twenty oncocytomas expressed cytokeratin, 16 in a distinctive punctate pattern. These same 16 tumors also contained small globular filamentous bod...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109016259
更新日期:1991-07-01 00:00:00
abstract::Low molecular weight proteins are normally, essentially, entirely catabolized by the proximal tubules. Physiological and pathological aspects of the renal interactions of three of these proteins: light chains, B-2 microglobulin, and myoglobin share similarities, but are also unique in certain ways. In pathological con...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913129409016277
更新日期:1994-01-01 00:00:00
abstract::Since 1980 when Sibley and coworkers first described a nodal neoplasm of unknown histogenesis with striking surface microvilli for which they introduced the term "anemone cell," a series of reports have appeared in the literature illustrating tumors with similar ultrastructural features. While most reported cases show...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120309931
更新日期:2003-03-01 00:00:00
abstract::Tissue biopsies and peripheral blood samples from 10 patients with the characteristic clinical features of acquired immunodeficiency syndrome (AIDS) were examined by electron microscopy and ultracytochemical myeloperoxidase technique. Abundant tubuloreticular inclusions (TRI) were detected within the endoplasmic retic...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309140585
更新日期:1983-06-01 00:00:00
abstract::Helicobacter pylori is believed to cause chronic active gastritis. Infection/colonization of the gastric mucosal surface induces a mucosal inflammatory reaction in the form of lymphocytic aggregates, plasma cells and, particularly, neutrophils, which may, in turn, damage the mucosal epithelium. In vitro studies demons...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131200750035049
更新日期:2000-09-01 00:00:00
abstract::Electron microscopic investigation of biopsy materials from Kaposi sarcoma (KS) skin lesions of 2 African AIDS patients occasionally revealed fungal cells within the tumor tissue. The spherical cells were surrounded by a triple-layered cell wall and were not encapsulated. The ultrastructural characteristics of the cel...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120500520960
更新日期:2006-05-01 00:00:00
abstract::Clear-cell carcinomas of the female genital tract are uncommon tumors that usually arise in the ovary, cervix, or vagina. The objectives of the present study were to examine the immunohistochemical and ultrastructural characteristics of 18 of these tumors and to determine whether any distinctive features were present ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016357
更新日期:1996-11-01 00:00:00