Abstract:
:Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease. Thirty-two BALB/c mice were divided (n = 8) as follows: control; Dex (dexmedetomidine) (30 μg/kg) for 6 days; TNBS 150 μL, TNBS + ethanol (50% w/v) intrarectally; TNBS + Dex. The histopathological and ultrastructural changes were evaluated. The levels of malondialdehyde (MDA), activity of antioxidant enzymes (GPx and SOD) were measured in liver tissue. Induction of colitis induced histopathological and ultrastructural changes of damage in liver. Those changes were markedly reduced in the TNBS + Dex group and that reduction was even significant in comparison to the TNBS group. MDA levels were significantly higher in the TNBS group and dexmedetomidine significantly elevated SOD levels in the TNBS + Dex group. These results suggest that the administration of dexmedetomidine reduces the histopathological and ultrastructural damage and increases the defense capacity against oxidative damage on liver in this IBD mice model.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Gul M,Kayhan B,Elbe H,Dogan Z,Otlu Adoi
10.3109/01913123.2013.829150subject
Has Abstractpub_date
2015-02-01 00:00:00pages
6-12issue
1eissn
0191-3123issn
1521-0758journal_volume
39pub_type
杂志文章abstract::A glomangioma (glomus tumor) arising in the pituitary region is described. The histologic and ultrastructural features were characteristic. The tumor was composed of epithelioid cells arranged in an organoid fashion around vascular channels and contained scattered mast cells. Electron microscopy revealed tumor cells t...
journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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abstract::Adult neuroblastoma is an uncommon tumor and it is rare for one to present as a primary bone lesion. We report the case of a 23-year-old man in whom the tumor initially appeared in the right scapula. Light microscopic, immunocytochemical, and electron microscopic findings were typical of neuroblastoma. ...
journal_title:Ultrastructural pathology
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abstract::Transmission electron microscopy has played a key role in our understanding of the human immunodeficiency virus and the opportunistic infections that accompany HIV disease. This paper describes features of HIV production; HHV-8, the virus that is associated with Kaposi sarcoma; Trachipleistophora anthropophthera, a ne...
journal_title:Ultrastructural pathology
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更新日期:2002-07-01 00:00:00
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journal_title:Ultrastructural pathology
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