Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.

Abstract:

:Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of 30 days, the olfactory epithelium (OE) of NGF-applied diabetic rats regenerated, the epithelium thickness was significantly higher, and caspase-3 expression was not significantly different from the control. The current results demonstrate that intranasally administered NGF significantly reversed OE morphological changes in diabetes by decreasing diabetes-related cell death and inflammation.

journal_name

Ultrastruct Pathol

authors

Yalim S,Dağlıoğlu K,Coskun G,Polat S

doi

10.1080/01913123.2018.1463337

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

246-254

issue

3

eissn

0191-3123

issn

1521-0758

journal_volume

42

pub_type

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