Cytokeratin-containing globular filamentous bodies in renal oncocytoma.

Abstract:

:Eighty-four cortical neoplasms were studied for cytokeratin and vimentin expression by immunohistochemistry and for intermediate filament aggregates by electron microscopy. Twenty oncocytomas expressed cytokeratin, 16 in a distinctive punctate pattern. These same 16 tumors also contained small globular filamentous bodies (GFB) by electron microscopy. The GFB were characterized by a matrix of intermediate-sized filaments with incorporation of diverse cell organelles such as endoplasmic reticulum, lysosomes, mitochondria, and lipid. The GFB were not within a unit membrane. Although 11 of 64 carcinomas also contained intermediate filament aggregates, only 2 of these solely expressed cytokeratin, and this was restricted to a few cells in small foci. Small GFB were also present in 5 carcinomas by electron microscopy. Three mixed clear and granular cell carcinomas contained only rare cells, whereas 2 sarcomatoid carcinomas, both of rhabdoid cell phenotype, contained numerous GFB that coexpressed vimentin and cytokeratin. Cytokeratin-containing GFB are common in oncocytomas but are uncommon in carcinoma, and, when numerous, may provide a diagnostically useful immunohistochemical feature with which to distinguish oncocytoma from its carcinoma congeners.

journal_name

Ultrastruct Pathol

authors

Bonsib SM,Bray C

doi

10.3109/01913129109016259

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

521-9

issue

4-5

eissn

0191-3123

issn

1521-0758

journal_volume

15

pub_type

杂志文章
  • Reduplicated basal lamina in clear-cell carcinoma of the ovary: an immunohistochemical and electron microscopic study.

    abstract::Clear-cell carcinomas of the female genital tract are uncommon tumors that usually arise in the ovary, cervix, or vagina. The objectives of the present study were to examine the immunohistochemical and ultrastructural characteristics of 18 of these tumors and to determine whether any distinctive features were present ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129609016357

    authors: Kwon TJ,Ro JY,Tornos C,Ordonez NG

    更新日期:1996-11-01 00:00:00

  • Alpha and beta subunits of glycoprotein hormones in argyrophil pituitary tumors with small granule cells.

    abstract::A group of 33 functionless pituitary tumors with small argyrophil groups (SAG) were collected from a series of 200 pituitary adenomas (16.5% of all adenomas). Histologically, the tumors showed an unusually high frequency of trabecular patterns, perivascular pseudo-rosettes, and oncocytoid transformation. Immunoreactiv...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309140570

    authors: Capella C,Buffa R,Usellini L,Frigerio B,Jehenson P,Sessa F,Solcia E

    更新日期:1983-01-01 00:00:00

  • Primitive neuroectodermal tumors: ultrastructural and immunohistochemical studies.

    abstract::We report here ultrastructural and immunohistochemical studies of neuroblastic differentiation in the retrospective (n = 17) and prospective (n = 26) series of primitive neuroectodermal tumors (PNETs). By electron microscopy, neuritelike structures containing parallel-oriented microtubules, adhesive plaque junctions, ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129509064217

    authors: Papierz W,Alwasiak J,Kolasa P,Wegrzyn Z,Zakrzewski K,Polis L,Debiec-Rychter M,Liberski PP

    更新日期:1995-05-01 00:00:00

  • Detection of villous conidia of Conidiobolus coronatus in a blood sample by scanning electron microscopy investigation.

    abstract::Conidiobolus coronatus is a major insect pathogen belonging to the fungal order Entomophthorales, causing a rare subcutaneous infection of the nasofacial region, resulting in swelling of predominantly the nose, mouth, and perinasal tissue. Later in the course of the infection firm, painless, subcutaneous nodules devel...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120500482013

    authors: Hoogendijk CF,Pretorius E,Marx J,Van Heerden WE,Imhof A,Schneemann M

    更新日期:2006-01-01 00:00:00

  • Neuronal ceroid lipofuscinosis: an ultrastructural, genetic, and clinical study report.

    abstract::The term "neuronal ceroid lipofuscinosis" (NCL) describes a complex of inherited neurodegenerative conditions associated with storage of lipopigments in brain tissue. In 1989 Dyken proposed a classification of NCL based on the age, clinical symptoms, and ultrastructural aspects of the lipopigments. At the ultrastructu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131201300004681

    authors: Boldrini R,Biselli R,Santorelli FM,Bosman C

    更新日期:2001-01-01 00:00:00

  • Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.

    abstract::Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2018.1463337

    authors: Yalim S,Dağlıoğlu K,Coskun G,Polat S

    更新日期:2018-05-01 00:00:00

  • Ultrastructural analysis of the Krebs-2 ascites cancer cells treated with extracellular double-stranded DNA preparation.

    abstract::Electron-microscopic analysis of the ultrastructure of the Krebs-2 carcinoma ascites cells in the first 90 min immediately after their exposure to fragmented double-stranded DNA has been performed. Morphological attributes of the treated cancer cells indicate the induction in these cells of destructive processes of pr...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2019.1575499

    authors: Kirikovich SS,Taranov OS,Omigov VV,Potter EA,Dolgova EV,Proskurina AS,Efremov YR,Bogachev SS

    更新日期:2019-01-01 00:00:00

  • Electron microscopy of histologically difficult to diagnose gynecologic neoplasms.

    abstract::The ultrastructural characteristics useful in identifying a selected series of histologically difficult to diagnose malignant neoplasms of the human gynecological sphere are presented. The results are discussed in relation to routine diagnosis and when appropriate, to their pathogenic origin. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128709048330

    authors: Ferenczy A

    更新日期:1987-01-01 00:00:00

  • Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells.

    abstract::One of the most constant and typical histological markers of thyroid papillary carcinoma is the presence of multilobated and ground-glass nuclei. With the intention of extending and characterizing the ultrastructural comprehension of this feature, thyroid papillary carcinoma cells and normal follicular cells were stud...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129809033471

    authors: Echeverría OM,Hernández-Pando R,Vázquez-Nin GH

    更新日期:1998-05-01 00:00:00

  • Metaplastic breast carcinoma invading chest wall.

    abstract::Metaplastic breast carcinoma refers to a heterogeneous group of neoplasms in which the typical glandular growth pattern of the tumor undergoes metaplasia, either epithelial or stromal. A 59-year-old woman presented with a breast mass that recurred in 1 year and showed invasion of the chest wall. Histological sections ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129509021916

    authors: Harb JM,Komorowski RA,Vitali CM

    更新日期:1995-09-01 00:00:00

  • Adult neuroblastoma of bone: a case report.

    abstract::Adult neuroblastoma is an uncommon tumor and it is rare for one to present as a primary bone lesion. We report the case of a 23-year-old man in whom the tumor initially appeared in the right scapula. Light microscopic, immunocytochemical, and electron microscopic findings were typical of neuroblastoma. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128709048440

    authors: Mackay B,Ordóñez NG

    更新日期:1987-01-01 00:00:00

  • Heterogeneity of malignant schwannomas.

    abstract::Six malignant schwannomas were studied by electron microscopy and immunohistochemistry for S-100 protein at the light and electron microscopic levels to clarify the nature of the tumor cells. Three tumors (group A) were composed of poorly differentiated tumor cells and showed no immunoreactivity for S-100 protein. One...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809048479

    authors: Hirose T,Sano T,Hizawa K

    更新日期:1988-01-01 00:00:00

  • Chromogranin A and vesicular monoamine transporter 2 immunolocalization in protein bodies of human locus coeruleus neurons.

    abstract::Our previous histochemical and ultrastructural studies have identified, in human catecholamine neurons, abundant spherical acidophilic protein bodies (pb), which originate from regular mitochondria, retaining their double membrane. In locus coeruleus (LC) neurons, pb have somatodendritic distribution and are unequivoc...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2012.750410

    authors: Kloukina-Pantazidou I,Chrysanthou-Piterou M,Havaki S,Issidorides MR

    更新日期:2013-04-01 00:00:00

  • A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.

    abstract::Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/01913123.2013.815081

    authors: Funkhouser WK 3rd,Niethammer M,Carson JL,Burns KA,Knowles MR,Leigh MW,Zariwala MA,Funkhouser WK Jr

    更新日期:2014-08-01 00:00:00

  • Low-grade spindle cell carcinoma of the kidney.

    abstract::The authors report a renal cell carcinoma composed largely of spindle cells of Fuhrman's nuclear grade II in which the bland appearance of the cells and low mitotic index were reminiscent of a benign or low-grade smooth muscle tumor. Keratin immunostaining was positive, but evidence of epithelial differentiation was o...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129809032262

    authors: Lloreta J,Corominas JM,Munné A,Domínguez D,Bielsa O,Gelabert A,Serrano S

    更新日期:1998-01-01 00:00:00

  • Malignant epithelial mesothelioma of the peritoneum: observations on a problem case.

    abstract::A 71-year-old asbestos-exposed male with symptoms suggestive of asbestosis for the previous 8 years presented with abdominal distension and ascites. Clinically, a diagnosis of mesothelioma carcinoma was made. Light microscopy of an omental biopsy failed to advance the diagnosis: The tumor was a solid, papillary, and g...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129609016334

    authors: Eyden BP,Banik S,Harris M

    更新日期:1996-07-01 00:00:00

  • Ultrastructural changes suggestive of focal segmental glomerulosclerosis in atypical minimal change nephrotic syndrome.

    abstract::In an attempt to recognize early stages of focal segmental glomerulosclerosis (FSGS) in patients with a clinical course suggesting a diagnosis other than minimal change disease (MCD) and normal histology, or minor, nondiagnostic changes on light microscopy (LM), we used a protocol for systematic and extensive electron...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809048472

    authors: Ben-Bassat M,Braslavsky D,Lotan D,Eisenstein B,Davidovitz M,Stark H

    更新日期:1988-01-01 00:00:00

  • Intracisternal tubules in human melanoma cells.

    abstract::Aggregates of parallel microtubules have been found within cisternae of the rough endoplasmic reticulum in cells of six human metastatic melanomas. The tubules have a uniform diameter and regular spacing and in longitudinal sections can be seen to possess a fine periodicity. They are compared with tubuloreticular incl...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128009141389

    authors: Mackay B,Ayala AG

    更新日期:1980-01-01 00:00:00

  • An ultrastructural study of mast cell interactions in hemangiomas.

    abstract::Hemangiomas, the most common tumors of infancy, are characterized by a postnatal period of rapid growth, followed by a phase of gradual involution. The proliferative phase is characterized by increased numbers of endothelial and mast cells and thickened basement membrane. Ultrastructural analysis of hemangiomas in the...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128609014593

    authors: Dethlefsen SM,Mulliken JB,Glowacki J

    更新日期:1986-01-01 00:00:00

  • An electron microscopic study of central nervous system sarcoidosis.

    abstract::Although the fine structure of extraneural sarcoidosis is well documented, ultrastructural study of central nervous system (CNS) sarcoidosis has been limited. Electron microscopic (EM) examination of 3 biopsy cases of CNS sarcoid revealed a mixed cellular population of lymphocytes, epitheloid cells, and multinucleated...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128109048309

    authors: Trombley IK,Mirra SS,Miles ML

    更新日期:1981-07-01 00:00:00

  • Correlation of proteinuria with podocyte foot process effacement in IgA nephropathy: an ultrastructural study.

    abstract:BACKGROUND:Proteinuria is an uncommon clinical manifestation of IgA nephropathy and is usually seen in cases with severe lesions like endocapillary proliferation. However, it is occasionally seen even with cases with mild glomerular manifestations and may even be of nephrotic range. PREDICTOR:Podocyte foot process eff...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2014.960543

    authors: Tewari R,Nada R,Rayat CS,Boruah D,Dudeja P,Joshi K,Sakhuja V

    更新日期:2015-04-01 00:00:00

  • Annulate lamellae in a large cell lung carcinoma cell line with high expression of tyrosine kinase receptor and proto-oncogenes.

    abstract::The morphology, karyotype, in vitro growth properties, and expression of tyrosine kinase receptors and proto-oncogenes are reported for a newly established large cell undifferentiated lung carcinoma cell line (RVH-6849). The results were analyzed concomitantly with those for two well-established cell lines from an ade...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209057829

    authors: Wang NS,Liu C,Emond J,Tsao MS

    更新日期:1992-07-01 00:00:00

  • Myxoid liposarcoma: study of ten cases.

    abstract::The ultrastructure of 10 myxoid liposarcomas from 9 patients is presented. Features closely resembling those of developing fetal adipose tissue were seen in all tumors. THe various cell types identified ranged from undifferentiated cells to typical multivacuolated and univacuolated lipoblasts. In addition, a secretory...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128009141413

    authors: Battifora H,Nunez-Alonso C

    更新日期:1980-04-01 00:00:00

  • Phenotype/genotype correlations in the ultrastructure of monogenetic glomerular diseases.

    abstract::Electron microscopy defined classic patterns of hereditary glomerular disease long before genetics revealed an underlying specific mutation. Genetic analysis is now easier to perform in clinical practice but an earlier optimism that genetics would predict disease severity and phenotype is challenged. The classic parad...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.1080/019131290505194

    authors: Liapis H,Foster K,Theodoropoulou E,Monga G,Pizzolitto S,Mazzucco G

    更新日期:2004-07-01 00:00:00

  • Extrusion of amyloid fibrils to the extracellular space in experimental mesangial AL-amyloidosis: transmission and scanning electron microscopy studies and correlation with renal biopsy observations.

    abstract::In vitro studies have provided much information regarding the process of glomerular AL-amyloidogenesis. Research efforts have been successful in deciphering how glomerulopathic light chains interact with mesangial cells. The sequential steps involved in the genesis of amyloid fibrils include interactions with surface ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2013.861568

    authors: Teng J,Turbat-Herrera EA,Herrera GA

    更新日期:2014-04-01 00:00:00

  • Ultrastructural GABA immunogold labeling in the substantia nigra pars reticulata of kindled genetic absence epilepsy rats.

    abstract::Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a well-known animal model of absence epilepsy and they are resistant to electrical kindling stimulations. The present study aimed to examine possible differences in gamma-aminobutyric acid (GABA) levels and synapse counts in the substantia nigra pars reticulata ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2020.1839153

    authors: Sirvanci S,Akakin D,Gulcebi İdrizoglu M,Kaya OT,Karamahmutoglu T,Turgan Aşık ZN,Onat F

    更新日期:2020-11-20 00:00:00

  • Ameliorative effect of Pimpinella anisum oil on immunohistochemical and ultrastuctural changes of cerebellum of albino rats induced by aspartame.

    abstract::The study aims to investigate the protective effect of Pimpinella anisum oil on aspartame (ASP) which resulted in cerebellar changes. The rats were divided into four equal groups: Group 1: (control group): served as control animals. Group 2: control P. anisum oil received .5 mL/kg/d/b wt. once daily. Group 3 (ASP grou...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2014.889259

    authors: Abdul-Hamid M,Gallaly SR

    更新日期:2014-05-01 00:00:00

  • Sarcomatous type of malignant mesothelioma.

    abstract::Thirteen malignant mesotheliomas of a sarcomatous type were studied by light microscopy and ten were studied by electron microscopy. The histologic patterns varied from tumor to tumor, often resembling other soft tissue sarcomas. Electron microscopic observation showed most of the tumors to be composed of primitive ce...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309140587

    authors: Klima M,Bossart MI

    更新日期:1983-06-01 00:00:00

  • A fast method for processing biologic material for electron microscopic diagnosis in infectious disease.

    abstract::A fast method for processing biologic material for electron microscopy for precise and specific diagnosis of infectious agents is an increasing necessity. After different, reportedly fast methods were tested, a useful and quick technique was developed that provides well-preserved cellular structures, enabling the etio...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209057832

    authors: Duarte MI,Mariano ON,Takakura CF,Everson D,Corbett CE

    更新日期:1992-07-01 00:00:00

  • Enhancement of intracellular delivery of anti-cancer drugs by the Tat peptide.

    abstract::The arginine-rich cationic Tat peptides have been reported to enhance the intracellular delivery of macromolecules, including DNA, RNA, and proteins. In this work an arginine cationic peptide derived from the HIV-1 Tat protein was conjugated with noncovalent bonds to sulfonated aluminum phthalocyanine (AlPcS, a photos...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2011.557522

    authors: Zhao JF,Chen JY,Mi L,Wang PN,Peng Q

    更新日期:2011-05-01 00:00:00