Abstract:
:Hemangiomas, the most common tumors of infancy, are characterized by a postnatal period of rapid growth, followed by a phase of gradual involution. The proliferative phase is characterized by increased numbers of endothelial and mast cells and thickened basement membrane. Ultrastructural analysis of hemangiomas in the late proliferative phase showed that mast cells had numerous fingerlike processes aligned parallel to the outer lamina of the thickened basement membranes surrounding the vessels and to the surfaces of opposing cell membranes. We found evidence of different types of interactions between mast cells and adjacent connective tissue cells (fibroblasts, macrophages, multinucleated giant cells, and plasma cells) in the perivascular regions of the lesions. Intercellular contacts were observed in areas where these mast cell processes were in close association to the opposing cell membrane. Areas of membrane fusions were seen between cell types. Coated vesicles and pinocytotic vesicles were present along the periphery of cells adjacent to mast cells. Occasionally, cytoplasmic bridges were found between mast cells and fibroblasts. These ultrastructural findings suggest the proliferation and involution of hemangiomas are determined by interactions between the various types of cells found in the lesions.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Dethlefsen SM,Mulliken JB,Glowacki Jdoi
10.3109/01913128609014593subject
Has Abstractpub_date
1986-01-01 00:00:00pages
175-83issue
2eissn
0191-3123issn
1521-0758journal_volume
10pub_type
杂志文章abstract::Low molecular weight proteins are normally, essentially, entirely catabolized by the proximal tubules. Physiological and pathological aspects of the renal interactions of three of these proteins: light chains, B-2 microglobulin, and myoglobin share similarities, but are also unique in certain ways. In pathological con...
journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
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journal_title:Ultrastructural pathology
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